Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study

• Published in: Scientific reports Vol. 13; no. 1; p. 13622
• Main Authors: Fongang, Bernard, Satizabal, Claudia, Kautz, Tiffany F., Wadop, Yannick N., Muhammad, Jazmyn A. S., Vasquez, Erin, Mathews, Julia, Gireud-Goss, Monica, Saklad, Amy R., Himali, Jayandra, Beiser, Alexa, Cavazos, Jose E., Mahaney, Michael C., Maestre, Gladys, DeCarli, Charles, Shipp, Eric L., Vasan, Ramachandran S., Seshadri, Sudha
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1341; 631/378/2612; 631/378/2649; 692/617/375; Alzheimer's disease; AMP-Activated Protein Kinases; Bacteria; Cerebral Small Vessel Diseases; Chemical communication; Cognition; Cognitive ability; Cross-Sectional Studies; Dementia disorders; Dysbacteriosis; Dysbiosis; Executive function; Gram-negative bacteria; Humanities and Social Sciences; Humans; Intestinal microflora; Kinases; Microbiomes; Microbiota; multidisciplinary; Neurodegenerative diseases; Neuroimaging; Quorum sensing; RNA, Ribosomal, 16S; rRNA 16S; Science; Science (multidisciplinary); Substantia alba; Vascular diseases

A bidirectional communication exists between the brain and the gut, in which the gut microbiota influences cognitive function and vice-versa. Gut dysbiosis has been linked to several diseases, including Alzheimer's disease and related dementias (ADRD). However, the relationship between gut dysb...