Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions

• Published in: Nature communications Vol. 14; no. 1; pp. 3594 - 13
• Main Authors: Alfieri, Fabio, Caravagna, Giulio, Schaefer, Martin H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.06.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 631/114; 631/181/2468; 631/208/737/1505; 631/67/2329; 631/67/69; Cancer; Chromosome aberrations; Copy number; DNA Copy Number Variations; Evolution; Evolutionary genetics; Genes; Genome; Genomes; Humanities and Social Sciences; Humans; multidisciplinary; Mutation; Neoplasms - genetics; Science; Science (multidisciplinary); Tumors

Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious, almost all protein-coding genes lack detectable signals of negative selection. This raises the question of how tumors tolerate such large amounts of delet...