Cross-reactive MHC class I T cell epitopes may dictate heterologous immune responses between respiratory viruses and food allergens

• Published in: Scientific reports Vol. 13; no. 1; pp. 14874 - 7
• Main Authors: Balz, Kathrin, Kaushik, Abhinav, Cemic, Franz, Sampath, Vanitha, Heger, Vanessa, Renz, Harald, Nadeau, Kari, Skevaki, Chrysanthi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.09.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/1619/554; 631/250/21/324/1509; 631/250/249/2510/31; 631/250/249/2510/9; Allergens; Allergies; Asthma; Bioinformatics; Cell-mediated immunity; COVID-19; Epitopes; Epitopes, T-Lymphocyte; Food; Food allergies; Food Hypersensitivity; Humanities and Social Sciences; Humans; Immune response; Immunization; Immunogenicity; Immunomodulation; Influenza; Lymphocytes; Lymphocytes T; Major histocompatibility complex; multidisciplinary; Peptides; Proteomes; Respiratory syncytial virus; Rhinovirus; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Soybeans; Viruses

Respiratory virus infections play a major role in asthma, while there is a close correlation between asthma and food allergy. We hypothesized that T cell-mediated heterologous immunity may induce asthma symptoms among sensitized individuals and used two independent in silico pipelines for the identi...