Hormonal modulation of ESR1 mutant metastasis

• Published in: Oncogene Vol. 40; no. 5; pp. 997 - 1011
• Main Authors: Gu, Guowei, Tian, Lin, Herzog, Sarah K., Rechoum, Yassine, Gelsomino, Luca, Gao, Meng, Du, Lili, Kim, Jin-Ah, Dustin, Derek, Lo, Hin Ching, Beyer, Amanda R., Edwards, David G., Gonzalez, Thomas, Tsimelzon, Anna, Huang, Helen J., Fernandez, Natalie M., Grimm, Sandra L., Hilsenbeck, Susan G., Liu, Dan, Xu, Jun, Alaniz, Alyssa, Li, Shunqiang, Mills, Gordon B., Janku, Filip, Kittler, Ralf, Zhang, Xiang H. -F., Coarfa, Cristian, Foulds, Charles E., Symmans, W. Fraser, Andò, Sebastiano, Fuqua, Suzanne A. W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.02.2021; Nature Publishing Group
• Subjects: 14/63; 17β-Estradiol; 38/109; 38/39; 38/61; 38/70; 631/337/2019; 631/67/1347; 631/67/322; 631/67/70; 64/60; 82/80; 96/1; Androgen receptors; Animals; Antiestrogens; Apoptosis; Aromatase; Aromatase Inhibitors - pharmacology; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Care and treatment; Cell Biology; Cell Line, Tumor; Cell migration; Complications and side effects; Dihydrotestosterone; Dihydrotestosterone - pharmacology; Estradiol - metabolism; Estrogen; Estrogen Receptor alpha - genetics; Estrogen receptors; Estrogens; Estrogens - genetics; Female; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Gene mutations; Genetic aspects; Health aspects; Human Genetics; Humans; Internal Medicine; Lung cancer; Medicine; Medicine & Public Health; Mesenchyme; Metastases; Metastasis; Mice; Mutants; Mutation; Mutation - genetics; Neoplasm Metastasis; Oncology; Receptors; Receptors, Androgen - drug effects; Receptors, Androgen - genetics; Tamoxifen; Tamoxifen - pharmacology; Tumors; Xenograft Model Antitumor Assays; Xenografts; United States

Estrogen receptor alpha gene ( ESR1 ) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial–mesenchymal transition (EMT) with cells exhibiting enhanced migration and inva...