Diastereo- and atroposelective synthesis of N-arylpyrroles enabled by light-induced phosphoric acid catalysis

• Published in: Nature communications Vol. 14; no. 1; p. 4813
• Main Authors: Dai, Lei, Zhou, Xueting, Guo, Jiami, Dai, Xuan, Huang, Qingqin, Lu, Yixin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/933; 639/638/403/934; 639/638/77/883; Alkynes; Asymmetric synthesis; Asymmetry; Bioactive compounds; Biological activity; Catalysis; Catalysts; Chemical synthesis; Chirality; Humanities and Social Sciences; Ligands; Light effects; multidisciplinary; Natural products; Phosphates; Phosphoric acid; Scaffolds; Science; Science (multidisciplinary)

The C−N axially chiral N -arylpyrrole motifs are privileged scaffolds in numerous biologically active molecules and natural products, as well as in chiral ligands/catalysts. Asymmetric synthesis of N -arylpyrroles, however, is still challenging, and the simultaneous creation of contiguous C−N axial...