Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

• Published in: Cell death and differentiation Vol. 30; no. 6; pp. 1447 - 1456
• Main Authors: Potts, Margaret A., Mizutani, Shinsuke, Garnham, Alexandra L., Li Wai Suen, Connie S. N., Kueh, Andrew J., Tai, Lin, Pal, Martin, Strasser, Andreas, Herold, Marco J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2023; Nature Publishing Group
• Subjects: 13/1; 13/106; 38/91; 42/41; 631/250; 631/67; 64/60; Apoptosis; Biochemistry; Biomedical and Life Sciences; c-Myc protein; Cell Biology; Cell Cycle Analysis; Cell differentiation; CRISPR; Genomes; Life Sciences; Lymphocytes B; Lymphoma; Malignancy; Myc protein; Nucleotide sequence; Pax5 protein; Progenitor cells; Stem Cells; Transplantation

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic lesions have been discovered and their functions characterised, DNA sequence data of primary patient samples suggest that many more do exist. How...