Herpesvirus Infections in KIR2DL2-Positive Multiple Sclerosis Patients: Mechanisms Triggering Autoimmunity

• Published in: Microorganisms (Basel) Vol. 10; no. 3; p. 494
• Main Authors: Bortolotti, Daria, Gentili, Valentina, Bortoluzzi, Alessandra, Govoni, Marcello, Schiuma, Giovanna, Beltrami, Silvia, Rizzo, Sabrina, Baldi, Eleonora, Caselli, Elisabetta, Pugliatti, Maura, Castellazzi, Massimiliano, Fernández, Mercedes, Fainardi, Enrico, Rizzo, Roberta
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.02.2022; MDPI
• Subjects: Autoimmune diseases; Autoimmunity; Cytokines; Disease; DNA; Epstein-Barr virus; Flow cytometry; Herpes viruses; herpesvirus; Histocompatibility antigen HLA; humans; Immune response; Immune system; Immunoglobulin G; Immunoglobulins; Infections; Innate immunity; Interleukin 10; Interleukin 12; Interleukin 8; KIR; ligands; Mimicry; molecular mimicry; Multiple sclerosis; Natural killer cells; Neurological diseases; NK cell; Patients; Potassium channels (inwardly-rectifying); relapse; Remission; Rheumatology; sclerosis; Tumor necrosis factor; tumor necrosis factor-alpha; Viral infections; viral load; Italy; United Kingdom > UK; United States > US; Germany; KIR; herpesvirus; multiple sclerosis; NK cell

In multiple sclerosis (MS), there is a possible relationship with viral infection, evidenced by clinical evidence of an implication of infectious events with disease onset and/or relapse. The aim of this research is to study how human herpesvirus (HHVs) infections might dysregulate the innate immune...