A novel process for obtaining phenylpropanoic acid precursor using Escherichia coli with a constitutive expression system
Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans -cinnamic acid or p -coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a su...
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| Published in | Food science and biotechnology Vol. 25; no. 3; pp. 795 - 801 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
The Korean Society of Food Science and Technology
01.06.2016
한국식품과학회 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health.
Trans
-cinnamic acid or
p
-coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of
Rhodotorula glutinis
phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in
Escherichia coli
. To improve
trans
-cinnamic acid and
p
-coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of
de novo
producing 78.81 mg/L of
trans
-cinnamic acid and 34.67 mg/L of
p
-coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor. |
|---|---|
| AbstractList | Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans-cinnamic acid or p-coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of Rhodotorula glutinis phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in Escherichia coli. To improve trans-cinnamic acid and p-coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of de novo producing 78.81 mg/L of trans-cinnamic acid and 34.67 mg/L of p-coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor. Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans-cinnamic acid or p-coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of Rhodotorula glutinis phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in Escherichia coli. To improve trans-cinnamic acid and p-coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of de novo producing 78.81 mg/L of trans-cinnamic acid and 34.67 mg/L of p-coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor.Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans-cinnamic acid or p-coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of Rhodotorula glutinis phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in Escherichia coli. To improve trans-cinnamic acid and p-coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of de novo producing 78.81 mg/L of trans-cinnamic acid and 34.67 mg/L of p-coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor. Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans -cinnamic acid or p -coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of Rhodotorula glutinis phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in Escherichia coli . To improve trans -cinnamic acid and p -coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of de novo producing 78.81 mg/L of trans -cinnamic acid and 34.67 mg/L of p -coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor. Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. -cinnamic acid or -coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in . To improve -cinnamic acid and -coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of producing 78.81 mg/L of -cinnamic acid and 34.67 mg/L of -coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor. Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans-cinnamic acid or p-coumaric acid is usually used as the starting precursor to produce phenylpropanoids. Synthetic bioengineering of microbial cell factories offers a sustainable and flexible alternative method for obtaining these compounds. In this study, a constitutive expression system consisting of Rhodotorula glutinis phenylalanine/tyrosine ammonia lyase was developed to produce a phenylpropanoic acid precursor in Escherichia coli. To improve transcinnamic acid and p-coumaric acid production, BioBrick optimization was investigated, causing a 7.2- and 14.2-fold increase in the yield of these compounds, respectively. The optimum strain was capable of de novo producing 78.81 mg/L of trans-cinnamic acid and 34.67 mg/L of p-coumaric acid in a shake flask culture. The work presented here paves the way for the development of a sustainable and economical process for microbial production of a phenylpropanoic acid precursor. KCI Citation Count: 2 |
| Author | Lin, Junfang Guo, Weixiong Guo, Liqiong Sun, Ping Liang, Jing-long Jiang, Binghua Wan, Hua |
| Author_xml | – sequence: 1 givenname: Jing-long surname: Liang fullname: Liang, Jing-long organization: Department of Bioengineering, College of Food Science and Institute of Food Biotechnology, South China Agricultural University, Joint Research & Development Center for Natural Products of Alchemy Biotechnology Co. Ltd. and South China Agricultural University – sequence: 2 givenname: Liqiong surname: Guo fullname: Guo, Liqiong organization: Department of Bioengineering, College of Food Science and Institute of Food Biotechnology, South China Agricultural University, Joint Research & Development Center for Natural Products of Alchemy Biotechnology Co. Ltd. and South China Agricultural University – sequence: 3 givenname: Ping surname: Sun fullname: Sun, Ping organization: Department of Bioengineering, College of Food Science and Institute of Food Biotechnology, South China Agricultural University, Joint Research & Development Center for Natural Products of Alchemy Biotechnology Co. Ltd. and South China Agricultural University – sequence: 4 givenname: Binghua surname: Jiang fullname: Jiang, Binghua organization: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University – sequence: 5 givenname: Junfang surname: Lin fullname: Lin, Junfang email: linjf@scau.edu.cn organization: Department of Bioengineering, College of Food Science and Institute of Food Biotechnology, South China Agricultural University, Joint Research & Development Center for Natural Products of Alchemy Biotechnology Co. Ltd. and South China Agricultural University – sequence: 6 givenname: Weixiong surname: Guo fullname: Guo, Weixiong organization: Department of Bioengineering, College of Food Science and Institute of Food Biotechnology, South China Agricultural University, Joint Research & Development Center for Natural Products of Alchemy Biotechnology Co. Ltd. and South China Agricultural University – sequence: 7 givenname: Hua surname: Wan fullname: Wan, Hua organization: College of Informatics, South China Agricultural University |
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| Cites_doi | 10.2174/187152511796196498 10.1128/AEM.01411-07 10.1016/j.foodchem.2010.05.118 10.1007/s00253-013-5020-9 10.1016/j.procbio.2008.02.001 10.1007/s10295-009-0606-z 10.1126/science.1191652 10.1016/j.jbiotec.2013.07.030 10.1002/bit.24988 10.1128/AEM.02186-10 10.1016/j.ymben.2011.06.005 10.1186/1475-2859-11-153 10.1016/j.foodchem.2010.09.059 10.1016/j.enzmictec.2007.07.025 10.1006/mben.2000.0161 10.1128/AEM.00200-07 10.1073/pnas.1206346109 10.1007/s10529-013-1140-7 10.1016/j.ymben.2005.11.001 10.1128/AEM.02966-14 10.1021/mp7001472 10.1016/j.ymben.2012.11.009 10.1016/j.jbiosc.2014.12.002 10.1016/S0168-9452(01)00490-3 10.1186/1754-1611-2-5 10.1039/c0fo00103a 10.1016/j.foodchem.2011.09.118 10.1128/AEM.00405-15 10.1016/j.copbio.2013.08.009 10.1016/j.ymben.2011.02.002 10.1038/nbt.2355 10.1016/j.jnutbio.2010.07.004 10.1016/j.foodres.2013.01.062 10.1038/nbt.2461 |
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| Snippet | Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health.
Trans
-cinnamic acid or
p
-coumaric... Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. -cinnamic acid or -coumaric acid is... Phenylpropanoids are widely used in food supplements, pharmaceuticals, and cosmetics with diverse benefits to human health. Trans-cinnamic acid or p-coumaric... |
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| SubjectTerms | ammonia bioengineering Chemistry Chemistry and Materials Science cosmetics culture flasks dietary supplements drugs Escherichia coli Food Science gene expression human health Nutrition p-coumaric acid phenylalanine phenylpropanoids Rhodotorula glutinis tyrosine 식품과학 |
| Title | A novel process for obtaining phenylpropanoic acid precursor using Escherichia coli with a constitutive expression system |
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