Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field

• Published in: Nature communications Vol. 14; no. 1; pp. 1606 - 22
• Main Authors: Ma, Xiaotu, Liang, Xiaolong, Li, Yao, Feng, Qingqing, Cheng, Keman, Ma, Nana, Zhu, Fei, Guo, Xinjing, Yue, Yale, Liu, Guangna, Zhang, Tianjiao, Liang, Jie, Ren, Lei, Zhao, Xiao, Nie, Guangjun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 14/19; 59/5; 631/326/41/2173; 631/67/1059/2325; 639/925/352/2733; 64/60; 82/1; Animals; Anticancer properties; Antitumor activity; Bacteria; Biocompatibility; Coliforms; Colon; Colonic Neoplasms - therapy; Colorectal cancer; E coli; Female; Females; Gene expression; Genetic modification; Homing; Homing behavior; Humanities and Social Sciences; Immune response; Immune system; Immunogenicity; Immunotherapy; Iron oxides; Lipids; Lysis; Magnetic fields; Magnetic signals; Mice; Modular design; Modular engineering; multidisciplinary; Nanobodies; Nanocomposites; Nanoparticles; Neoplasms - pathology; Phagocytosis; Robots; Robustness; Science; Science (multidisciplinary); Toxicity; Tumors

Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression and drug release should be spatiotemporally controlled to avoid drug release in healthy tissues and undesired toxicity. Herein, we describe an alternating magneti...