ER stress-induced LINC00173 promotes the apoptosis of ovarian granulosa cells by regulating the HRK/PI3K/AKT pathway in polycystic ovary syndrome

• Published in: Scientific reports Vol. 14; no. 1; pp. 24636 - 12
• Main Authors: Zhao, Yuanyuan, Wu, Xiaoqian, Meng, Fanyu, Liu, Xiaorong, Yuan, Jingchuan, Zhang, Xuhui, Tian, Geng, Wu, Xiaohua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/337/384/2568; 631/80/82/23; 692/699/2743/2730; AKT protein; Apoptosis; Apoptosis - genetics; Endocrine disorders; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Female; Granulosa cells; Granulosa Cells - metabolism; Granulosa Cells - pathology; Harakiri; Humanities and Social Sciences; Humans; LINC00173; multidisciplinary; Ovaries; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT signaling pathway; Polycystic ovary syndrome; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Polycystic Ovary Syndrome - pathology; Proto-Oncogene Proteins c-akt - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Signal Transduction; Granulosa cells; Polycystic ovary syndrome; PI3K/AKT signaling pathway; LINC00173; Endoplasmic reticulum stress; Harakiri

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and metabolic abnormality disease that mainly affects women of reproductive age. LINC00173, a novel long noncoding RNA (lncRNA), has emerged as an important factor in the development of PCOS. However, the role of LINC00173 in PCOS de...