Antibody Fc receptor binding and T cell responses to homologous and heterologous immunization with inactivated or mRNA vaccines against SARS-CoV-2

• Published in: Nature communications Vol. 15; no. 1; pp. 7358 - 15
• Main Authors: Cohen, Carolyn A., Leung, Nancy H. L., Kaewpreedee, Prathanporn, Lee, Kelly W. K., Jia, Janice Zhirong, Cheung, Alan W. L., Cheng, Samuel M. S., Mori, Masashi, Ip, Dennis K. M., Poon, Leo L. M., Peiris, J. S. Malik, Cowling, Benjamin J., Valkenburg, Sophie A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 13/31; 631/250/2152; 631/250/590; Adult; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Avidity; Binding; BNT162 Vaccine - administration & dosage; BNT162 Vaccine - immunology; CD4 antigen; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Deactivation; Fc receptors; Female; Humanities and Social Sciences; Humans; Immunization; Immunization, Secondary; Immunogenicity; Immunogenicity, Vaccine; Immunoglobulin G; Immunoglobulin G - immunology; Lymphocytes; Lymphocytes T; Male; Middle Aged; mRNA; mRNA Vaccines - immunology; multidisciplinary; Neutralizing; Nucleocapsids; Peptides; Receptors; Receptors, Fc - immunology; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes - immunology; Vaccines; Vaccines, Inactivated - administration & dosage; Vaccines, Inactivated - immunology; Virions; γ-Interferon

Whole virion inactivated vaccine CoronaVac (C) and Spike (S) mRNA BNT162b2 (B) vaccines differ greatly in their ability to elicit neutralizing antibodies but have somewhat comparable effectiveness in protecting from severe COVID-19. We conducted further analyses for a randomized trial (Cobovax study...