EMBED: Essential MicroBiomE Dynamics, a dimensionality reduction approach for longitudinal microbiome studies

• Published in: NPJ systems biology and applications Vol. 9; no. 1; pp. 26 - 11
• Main Authors: Shahin, Mayar, Ji, Brian, Dixit, Purushottam D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.06.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/158; 631/57; Antibiotics; Bacteria; Bacteria - genetics; Behavior; Bioinformatics; Biomedical and Life Sciences; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Ecosystem biology; Ecosystems; Life Sciences; Longitudinal studies; Microbiomes; Microbiota - genetics; Systems Biology

Dimensionality reduction offers unique insights into high-dimensional microbiome dynamics by leveraging collective abundance fluctuations of multiple bacteria driven by similar ecological perturbations. However, methods providing lower-dimensional representations of microbiome dynamics both at the c...