Why We Like to Drink: A Functional Magnetic Resonance Imaging Study of the Rewarding and Anxiolytic Effects of Alcohol

People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain r...

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Bibliographic Details
Published inThe Journal of neuroscience Vol. 28; no. 18; pp. 4583 - 4591
Main Authors Gilman, Jodi M, Ramchandani, Vijay A, Davis, Megan B, Bjork, James M, Hommer, Daniel W
Format Journal Article
LanguageEnglish
Published United States Soc Neuroscience 30.04.2008
Society for Neuroscience
Subjects
Adult
Alcoholic Intoxication - drug therapy
Alcoholic Intoxication - etiology
Alcoholic Intoxication - pathology
Alcoholic Intoxication - psychology
Alcohols - administration & dosage
Analysis of Variance
Anti-Anxiety Agents - administration & dosage
Brain Mapping
Facial Expression
Female
Humans
Image Processing, Computer-Assisted - methods
Linear Models
Magnetic Resonance Imaging
Male
Oxygen - blood
Photic Stimulation - methods
Reward
Surveys and Questionnaires
Online AccessGet full text

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Abstract People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI.
AbstractList People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI.
People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI.People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI.
Author Davis, Megan B
Gilman, Jodi M
Hommer, Daniel W
Ramchandani, Vijay A
Bjork, James M
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Snippet People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain...
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StartPage 4583
SubjectTerms Adult
Alcoholic Intoxication - drug therapy
Alcoholic Intoxication - etiology
Alcoholic Intoxication - pathology
Alcoholic Intoxication - psychology
Alcohols - administration & dosage
Analysis of Variance
Anti-Anxiety Agents - administration & dosage
Brain Mapping
Facial Expression
Female
Humans
Image Processing, Computer-Assisted - methods
Linear Models
Magnetic Resonance Imaging
Male
Oxygen - blood
Photic Stimulation - methods
Reward
Surveys and Questionnaires
Title Why We Like to Drink: A Functional Magnetic Resonance Imaging Study of the Rewarding and Anxiolytic Effects of Alcohol
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https://pubmed.ncbi.nlm.nih.gov/PMC2730732
Volume 28
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