Total and H-specific GDF-15 levels increase in caloric deprivation independently of leptin in humans

• Published in: Nature communications Vol. 15; no. 1; pp. 5190 - 15
• Main Authors: Chrysafi, Pavlina, Valenzuela-Vallejo, Laura, Stefanakis, Konstantinos, Kelesidis, Theodoros, Connelly, Margery A., Mantzoros, Christos S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/319/1557; 692/163/2743/348; Adult; Animals; Deprivation; Energy; Energy balance; Energy Metabolism; Energy requirements; Female; Genetic diversity; Genetic variance; Growth Differentiation Factor 15 - blood; Growth Differentiation Factor 15 - genetics; Growth Differentiation Factor 15 - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Leptin; Leptin - blood; Leptin - metabolism; Lipid metabolism; Lipids; Lipoproteins; Male; Metabolism; Metabolites; Middle Aged; multidisciplinary; Science; Science (multidisciplinary); Starvation - metabolism; Stress response; Stress, Physiological; Triglycerides; Weight; Weight loss; Young Adult

Mitochondrial-secreted growth differentiation factor-15 (GDF-15) promotes weight loss in animals. Its effects in humans remain unclear, due to limited research and potential measurement interference from the H202D-variant. Our post-hoc analysis investigates total (irrespective of genetic variants) a...