Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis

• Published in: The pharmacogenomics journal Vol. 21; no. 6; pp. 682 - 690
• Main Authors: Sukasem, Chonlaphat, Sririttha, Suthida, Chaichan, Chonlawat, Nakkrut, Thapanat, Satapornpong, Patompong, Jaruthamsophon, Kanoot, Jantararoungtong, Thawinee, Koomdee, Napatrupron, Medhasi, Sadeep, Oo-Puthinan, Sarawut, Rerkpattanapipat, Ticha, Klaewsongkram, Jettanong, Rerknimitr, Pawinee, Tuchinda, Papapit, Chularojanamontri, Leena, Tovanabutra, Napatra, Suvannang, Naravut, Rungrotmongkol, Thanyada, Saokaew, Surasak, Aekplakorn, Wichai, Puangpetch, Apichaya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2021; Nature Publishing Group
• Subjects: 38/47; 38/77; 631/154/53/2422; 692/53/2422; 692/700/1750; Adverse and side effects; Alleles; Allelomorphism; Anticonvulsants; Anticonvulsants - adverse effects; Antiepileptic agents; Antigens; Biomedical and Life Sciences; Biomedicine; Carbamazepine; Case-Control Studies; Complications and side effects; Cutaneous manifestations of general diseases; Drug Eruptions - diagnosis; Drug Eruptions - genetics; Drug Eruptions - immunology; Drugs; Eosinophilia; Gene Expression; Gene Frequency; Genetic aspects; Genotype; Genotypes; Health aspects; Heterocyclic Compounds - adverse effects; Histocompatibility antigen HLA; Histocompatibility antigens; HLA histocompatibility antigens; HLA-B Antigens - genetics; Human Genetics; Humans; Lamotrigine; Meta-analysis; Oligonucleotides; Oncology; Oxcarbazepine; Patients; Pharmacology, Experimental; Pharmacotherapy; Phenobarbital; Phenotypes; Phenytoin; Polymerase chain reaction; Population genetics; Population studies; Psychopharmacology; Risk Assessment; Risk Factors; Seizures; Thailand; Toxic epidermal necrolysis; Thailand

Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B ( HLA-B ) alleles have been linked to AEDs-induced cADRs. We investigated the association between cADRs (i...