Characterization of the Gene Encoding S-adenosyl-L-methionine (AdoMet) Synthetase in Penicillium chrysogenum; Role in Secondary Metabolism and Penicillin Production

• Published in: Microorganisms (Basel) Vol. 10; no. 1; p. 78
• Main Authors: Domínguez-Santos, Rebeca, Kosalková, Katarina, Sánchez-Orejas, Isabel-Clara, Barreiro, Carlos, Pérez-Pertejo, Yolanda, Reguera, Rosa M., Balaña-Fouce, Rafael, García-Estrada, Carlos
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.12.2021; MDPI
• Subjects: Amides; Antibiotics; Benzylpenicillin; Biosynthesis; Chromatin; computer simulation; Epigenetics; Experiments; Functional analysis; Fungi; Gene expression; genes; Genomes; Homocysteine; Industrial production; L-Homocysteine; Metabolism; Metabolites; Methionine; methionine adenosyltransferase; methyltransferases; Penicillin; Penicillium chrysogenum; Polyamines; Potassium; RNA-mediated interference; S-adenosyl-L-methionine; S-adenosylmethionine; secondary metabolism; Spermidine; Standard deviation; β-Lactam antibiotics; Germany; penicillin; S-adenosyl-L-methionine; polyamines; secondary metabolism; Penicillium chrysogenum

The filamentous fungus Penicillium chrysogenum (recently reidentified as Penicillium rubens) is used in the industrial production of the β-lactam antibiotic penicillin. There are several mechanisms regulating the production of this antibiotic, acting both at the genetic and epigenetic levels, the la...