Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway - Yang, Yuxin; Tang, Xiangting; Yao, Ting; Zhang, Yiqing; Zhong, Yufei; Wu, Shuqing; Wang, Yurou; Pan, Zezheng (Scientific reports, 2024)
Keywords: 631/1647; 631/337; 631/45; 692/163; 692/308; 692/420; 692/699; AMP-Activated Protein Kinases - metabolism; Animal models; Animals; Antidiabetics; Antineoplastic Agents - pharmacology; Busulfan; Cell culture; Chemotherapy; Cyclophosphamide; Female; Granule cells; Granulosa cells; Granulosa Cells - metabolism; Humanities and Social Sciences; Humans; Inflammation; Macrophages; Metformin; Metformin - therapeutic use; Mice; multidisciplinary; Ovaries; Oxidative stress; Peroxisome proliferator-activated receptors; Peroxisome Proliferator-Activated Receptors - metabolism; Primary Ovarian Insufficiency - chemically induced; Primary Ovarian Insufficiency - drug therapy; Primary Ovarian Insufficiency - prevention & control; Reproductive health; Reproductive status; Science; Science (multidisciplinary); Senescence; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism