Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis

• Published in: Scientific reports Vol. 14; no. 1; pp. 8229 - 12
• Main Authors: Pratama, Gita, Wiweko, Budi, Asmarinah, Widyahening, Indah S., Andraini, Trinovita, Bayuaji, Hartanto, Hestiantoro, Andon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/494; 631/443/494/2732; 631/92; 631/92/1643; 692/163; Adiponectin; AMH; Dynorphin; Endocrine disorders; FAI; Fasting; Follicle-stimulating hormone; Gonadotropin-releasing hormone; HOMA-IR; Humanities and Social Sciences; Hypothalamus; Kiss1 protein; Kisspeptin; Laboratory testing; Leptin; Luteinizing hormone; multidisciplinary; Neurokinin; Neurokinin B; Pathophysiology; Patients; Polycystic ovary syndrome; Science; Science (multidisciplinary); Secretion; Testosterone; Therapeutic targets; Kisspeptin; LH/FSH ratio; HOMA-IR; Neurokinin B; Lean; PCOS; Dynorphin; AMH; FAI

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms and not on its pathophysiology. Neuroendocrine disturbance, as shown by an elevated LH/FSH ratio in PCOS patients, was thought...