Comparative analysis of aldosterone and renin assays for primary aldosteronism screening

The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns over its impact on primary aldosteronism (PA) diagnosis. This study investigated the correlation between PAC and renin values using RIA, CLE...

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Published inScientific reports Vol. 14; no. 1; pp. 26040 - 14
Main Authors Taki, Yuki, Kono, Takashi, Teruyama, Kyoko, Ichijo, Takamasa, Sakuma, Ikki, Nagano, Hidekazu, Miyagawa, Hiroka, Kono, Satomi, Fujimoto, Masanori, Hashimoto, Naoko, Yokoyama, Masataka, Kawakami, Eiryo, Miki, Takashi, Tanaka, Tomoaki
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 29.10.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/45/776/1173
631/45/776/775
Adult
Aged
Aldosterone
Aldosterone - blood
Chemiluminescence
Chemiluminescent enzyme immunoassay
Chromatography, Liquid - methods
Comparative analysis
Diagnosis
Enzyme immunoassay
Female
Humanities and Social Sciences
Humans
Hyperaldosteronism - blood
Hyperaldosteronism - diagnosis
Liquid chromatography
Liquid chromatography/mass spectrometry/mass spectrometry
Male
Mass spectrometry
Mass spectroscopy
Middle Aged
multidisciplinary
Multiple regression analysis
Primary aldosteronism
Radioimmunoassay
Radioimmunoassay - methods
Renin
Renin - blood
Retrospective Studies
ROC Curve
Science
Science (multidisciplinary)
Scientific imaging
Tandem Mass Spectrometry - methods
Weak mineralocorticoid
Weak mineralocorticoid
Liquid chromatography/mass spectrometry/mass spectrometry
Primary aldosteronism
Aldosterone
Chemiluminescent enzyme immunoassay
Radioimmunoassay
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-024-75645-1

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Abstract The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns over its impact on primary aldosteronism (PA) diagnosis. This study investigated the correlation between PAC and renin values using RIA, CLEIA, and liquid chromatography/mass spectrometry/mass spectrometry (LC–MS/MS), established cutoff values for PA diagnosis using the aldosterone-to-renin ratio (ARR) with PAC_CLEIA, and assessed the differences in PAC values by measuring weak mineralocorticoids (WMs). This retrospective study evaluated 312 serum PAC samples using RIA, CLEIA, and LC–MS/MS, and analyzed 315 plasma renin samples. Method correlations were assessed through Passing-Bablok regression. Receiver operating characteristic curves determined ARR cutoffs for PA diagnosis. WMs were quantified to evaluate their impact on ΔPAC (RIA-LC–MS/MS) through multiple regression analysis. PAC_CLEIA and PAC_LC-MS/MS values were highly correlated. ARRs derived from PAC_RIAs demonstrated more false positives and lower specificity than ARRs using PAC_CLEIA or PAC_LC-MS/MS. WMs significantly influenced ΔPAC in both the PA and non-PA groups. ARRs using PAC_CLEIA are valuable for determining PA cutoffs in clinical practice. The transition to PAC using CLEIA may enhance PA detection rates. WMs were found to interfere with PAC measurements in the RIA method, affecting outcomes.
AbstractList Abstract The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns over its impact on primary aldosteronism (PA) diagnosis. This study investigated the correlation between PAC and renin values using RIA, CLEIA, and liquid chromatography/mass spectrometry/mass spectrometry (LC–MS/MS), established cutoff values for PA diagnosis using the aldosterone-to-renin ratio (ARR) with PAC_CLEIA, and assessed the differences in PAC values by measuring weak mineralocorticoids (WMs). This retrospective study evaluated 312 serum PAC samples using RIA, CLEIA, and LC–MS/MS, and analyzed 315 plasma renin samples. Method correlations were assessed through Passing-Bablok regression. Receiver operating characteristic curves determined ARR cutoffs for PA diagnosis. WMs were quantified to evaluate their impact on ΔPAC (RIA-LC–MS/MS) through multiple regression analysis. PAC_CLEIA and PAC_LC-MS/MS values were highly correlated. ARRs derived from PAC_RIAs demonstrated more false positives and lower specificity than ARRs using PAC_CLEIA or PAC_LC-MS/MS. WMs significantly influenced ΔPAC in both the PA and non-PA groups. ARRs using PAC_CLEIA are valuable for determining PA cutoffs in clinical practice. The transition to PAC using CLEIA may enhance PA detection rates. WMs were found to interfere with PAC measurements in the RIA method, affecting outcomes.
The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns over its impact on primary aldosteronism (PA) diagnosis. This study investigated the correlation between PAC and renin values using RIA, CLEIA, and liquid chromatography/mass spectrometry/mass spectrometry (LC–MS/MS), established cutoff values for PA diagnosis using the aldosterone-to-renin ratio (ARR) with PAC_CLEIA, and assessed the differences in PAC values by measuring weak mineralocorticoids (WMs). This retrospective study evaluated 312 serum PAC samples using RIA, CLEIA, and LC–MS/MS, and analyzed 315 plasma renin samples. Method correlations were assessed through Passing-Bablok regression. Receiver operating characteristic curves determined ARR cutoffs for PA diagnosis. WMs were quantified to evaluate their impact on ΔPAC (RIA-LC–MS/MS) through multiple regression analysis. PAC_CLEIA and PAC_LC-MS/MS values were highly correlated. ARRs derived from PAC_RIAs demonstrated more false positives and lower specificity than ARRs using PAC_CLEIA or PAC_LC-MS/MS. WMs significantly influenced ΔPAC in both the PA and non-PA groups. ARRs using PAC_CLEIA are valuable for determining PA cutoffs in clinical practice. The transition to PAC using CLEIA may enhance PA detection rates. WMs were found to interfere with PAC measurements in the RIA method, affecting outcomes.
The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns over its impact on primary aldosteronism (PA) diagnosis. This study investigated the correlation between PAC and renin values using RIA, CLEIA, and liquid chromatography/mass spectrometry/mass spectrometry (LC-MS/MS), established cutoff values for PA diagnosis using the aldosterone-to-renin ratio (ARR) with PAC_CLEIA, and assessed the differences in PAC values by measuring weak mineralocorticoids (WMs). This retrospective study evaluated 312 serum PAC samples using RIA, CLEIA, and LC-MS/MS, and analyzed 315 plasma renin samples. Method correlations were assessed through Passing-Bablok regression. Receiver operating characteristic curves determined ARR cutoffs for PA diagnosis. WMs were quantified to evaluate their impact on ΔPAC (RIA-LC-MS/MS) through multiple regression analysis. PAC_CLEIA and PAC_LC-MS/MS values were highly correlated. ARRs derived from PAC_RIAs demonstrated more false positives and lower specificity than ARRs using PAC_CLEIA or PAC_LC-MS/MS. WMs significantly influenced ΔPAC in both the PA and non-PA groups. ARRs using PAC_CLEIA are valuable for determining PA cutoffs in clinical practice. The transition to PAC using CLEIA may enhance PA detection rates. WMs were found to interfere with PAC measurements in the RIA method, affecting outcomes.The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns over its impact on primary aldosteronism (PA) diagnosis. This study investigated the correlation between PAC and renin values using RIA, CLEIA, and liquid chromatography/mass spectrometry/mass spectrometry (LC-MS/MS), established cutoff values for PA diagnosis using the aldosterone-to-renin ratio (ARR) with PAC_CLEIA, and assessed the differences in PAC values by measuring weak mineralocorticoids (WMs). This retrospective study evaluated 312 serum PAC samples using RIA, CLEIA, and LC-MS/MS, and analyzed 315 plasma renin samples. Method correlations were assessed through Passing-Bablok regression. Receiver operating characteristic curves determined ARR cutoffs for PA diagnosis. WMs were quantified to evaluate their impact on ΔPAC (RIA-LC-MS/MS) through multiple regression analysis. PAC_CLEIA and PAC_LC-MS/MS values were highly correlated. ARRs derived from PAC_RIAs demonstrated more false positives and lower specificity than ARRs using PAC_CLEIA or PAC_LC-MS/MS. WMs significantly influenced ΔPAC in both the PA and non-PA groups. ARRs using PAC_CLEIA are valuable for determining PA cutoffs in clinical practice. The transition to PAC using CLEIA may enhance PA detection rates. WMs were found to interfere with PAC measurements in the RIA method, affecting outcomes.
ArticleNumber 26040
Author Yokoyama, Masataka
Kawakami, Eiryo
Kono, Satomi
Miki, Takashi
Fujimoto, Masanori
Kono, Takashi
Taki, Yuki
Teruyama, Kyoko
Sakuma, Ikki
Miyagawa, Hiroka
Hashimoto, Naoko
Ichijo, Takamasa
Tanaka, Tomoaki
Nagano, Hidekazu
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Issue 1
Keywords Weak mineralocorticoid
Liquid chromatography/mass spectrometry/mass spectrometry
Primary aldosteronism
Aldosterone
Chemiluminescent enzyme immunoassay
Radioimmunoassay
Language English
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SSID ssj0000529419
Score 2.4485047
Snippet The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised concerns...
Abstract The transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for plasma aldosterone concentration (PAC) assays has raised...
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proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 26040
SubjectTerms 631/45/776/1173
631/45/776/775
Adult
Aged
Aldosterone
Aldosterone - blood
Chemiluminescence
Chemiluminescent enzyme immunoassay
Chromatography, Liquid - methods
Comparative analysis
Diagnosis
Enzyme immunoassay
Female
Humanities and Social Sciences
Humans
Hyperaldosteronism - blood
Hyperaldosteronism - diagnosis
Liquid chromatography
Liquid chromatography/mass spectrometry/mass spectrometry
Male
Mass spectrometry
Mass spectroscopy
Middle Aged
multidisciplinary
Multiple regression analysis
Primary aldosteronism
Radioimmunoassay
Radioimmunoassay - methods
Renin
Renin - blood
Retrospective Studies
ROC Curve
Science
Science (multidisciplinary)
Scientific imaging
Tandem Mass Spectrometry - methods
Weak mineralocorticoid
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Title Comparative analysis of aldosterone and renin assays for primary aldosteronism screening
URI https://link.springer.com/article/10.1038/s41598-024-75645-1
https://www.ncbi.nlm.nih.gov/pubmed/39472614
https://www.proquest.com/docview/3121801744
https://www.proquest.com/docview/3122635649
https://pubmed.ncbi.nlm.nih.gov/PMC11522277
https://doaj.org/article/00cc61d5324c43ca90c6c2c166d3c387
Volume 14
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