Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr)

• Published in: Molecular & cellular proteomics Vol. 17; no. 1; pp. 146 - 159
• Main Authors: Wu, Ying, Xiong, Qian, Li, Siting, Yang, Xue, Ge, Feng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2018; American Society for Biochemistry and Molecular Biology; The American Society for Biochemistry and Molecular Biology
• Subjects: Antisense RNA; Bioinformatics; Biological activity; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cell growth; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Growth factors; Hepatocellular carcinoma; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Molecular modelling; Narcotics; Opioid growth factor; Opioid receptors; Polymerase chain reaction; Proteins; Proteomics; Receptors, Opioid - genetics; Receptors, Opioid - metabolism; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signaling; Transcription; Tumorigenesis

Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative...