Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr)
Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative...
Saved in:
| Published in | Molecular & cellular proteomics Vol. 17; no. 1; pp. 146 - 159 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2018
American Society for Biochemistry and Molecular Biology The American Society for Biochemistry and Molecular Biology |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative proteomic analysis to systematically explore the regulatory role of HOTAIR in HCC. A total of 673 transcripts and 293 proteins were found to be dysregulated after HOTAIR inhibition. Bioinformatics studies indicated that differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) are involved in many biological processes, especially cancer-related signaling pathways. A set of DEGs and DEPs were validated by quantitative RT-PCR, Western blot and parallel reaction monitoring (PRM) analysis, respectively. Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its effects on cell proliferation, at least in part, through the regulation of OGFr expression. By correlating the omics data with functional studies, the current results provide novel insights into the functional mechanisms of HOTAIR in HCC cells. |
|---|---|
| AbstractList | Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative proteomic analysis to systematically explore the regulatory role of HOTAIR in HCC. A total of 673 transcripts and 293 proteins were found to be dysregulated after HOTAIR inhibition. Bioinformatics studies indicated that differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) are involved in many biological processes, especially cancer-related signaling pathways. A set of DEGs and DEPs were validated by quantitative RT-PCR, Western blot and parallel reaction monitoring (PRM) analysis, respectively. Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its effects on cell proliferation, at least in part, through the regulation of OGFr expression. By correlating the omics data with functional studies, the current results provide novel insights into the functional mechanisms of HOTAIR in HCC cells.Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative proteomic analysis to systematically explore the regulatory role of HOTAIR in HCC. A total of 673 transcripts and 293 proteins were found to be dysregulated after HOTAIR inhibition. Bioinformatics studies indicated that differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) are involved in many biological processes, especially cancer-related signaling pathways. A set of DEGs and DEPs were validated by quantitative RT-PCR, Western blot and parallel reaction monitoring (PRM) analysis, respectively. Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its effects on cell proliferation, at least in part, through the regulation of OGFr expression. By correlating the omics data with functional studies, the current results provide novel insights into the functional mechanisms of HOTAIR in HCC cells. Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative proteomic analysis to systematically explore the regulatory role of HOTAIR in HCC. A total of 673 transcripts and 293 proteins were found to be dysregulated after HOTAIR inhibition. Bioinformatics studies indicated that differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) are involved in many biological processes, especially cancer-related signaling pathways. A set of DEGs and DEPs were validated by quantitative RT-PCR, Western blot and parallel reaction monitoring (PRM) analysis, respectively. Further functional studies of the opioid growth factor receptor (OGFr), a negative biological regulator of cell proliferation in HCC, revealed that HOTAIR exerts its effects on cell proliferation, at least in part, through the regulation of OGFr expression. By correlating the omics data with functional studies, the current results provide novel insights into the functional mechanisms of HOTAIR in HCC cells. |
| Author | Ge, Feng Wu, Ying Xiong, Qian Yang, Xue Li, Siting |
| Author_xml | – sequence: 1 givenname: Ying surname: Wu fullname: Wu, Ying organization: From the Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China – sequence: 2 givenname: Qian surname: Xiong fullname: Xiong, Qian organization: From the Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China – sequence: 3 givenname: Siting surname: Li fullname: Li, Siting organization: From the Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China – sequence: 4 givenname: Xue surname: Yang fullname: Yang, Xue organization: From the Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China – sequence: 5 givenname: Feng surname: Ge fullname: Ge, Feng email: gefeng@ihb.ac.cn organization: From the Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29079719$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1rGzEQXUpK89HeeyqCXpyDXWm_tNtDwZjGNpi4GBd6E7I0chR2pa0ku_j_9odUaychDbQnDZr33jxm3mVyZqyBJHlP8Ihgmn9qRTdajQmhI4xxSumr5IIUWTGs8yo_e6ppeZ5cen8fIZjQ4k1yntaY1pTUF8nvuQmwdTyARN-cDWBbLRA3Eq0dN1443YXj19jw5uC1RyvYA288WlizRbfWCCt1rFa3YzRb_nhGi5SgPRgPqB_itmCiTo8bzJbr8Xx13U9s40yPZtDxYAU0za7hDk24E9rYlqNJ_OphjVYQXWpr0OYQPWwjLvRzl522WqKps7_CHbrhIlgX-wK6vhgspzfu-m3yWkXL8O7hvUq-33xdT2bDxXI6n4wXQ1HkJAzTXBYAWUkJJ7hOeVVnqZS1IjmXaVWCAl6XqiyU2JCCl7WimKQ4q1JVVkQplV0lX0663W7TghRgguMN65xuuTswyzX7u2P0HdvaPStogas8jwKDBwFnf-7AB9Zq32-FG7A7z0hd0LwqaFVG6McX0Hu7c_FInqUYlzXOcJlF1Ifnjp6sPAYgAsoTQDjrvQPFhA7HPUeDumEEsz5pLCaNHZPGTkmLRPyC-Kj9H8rnEwXiDfYaHPNCgxEgtQMRmLT63-Q_m9ruEg |
| CitedBy_id | crossref_primary_10_1111_jcmm_14649 crossref_primary_10_3390_ijms19030682 crossref_primary_10_1016_j_peptides_2020_170348 crossref_primary_10_1016_j_gene_2024_149180 crossref_primary_10_18632_aging_205523 crossref_primary_10_1186_s12964_020_00602_0 crossref_primary_10_3390_plants12010156 crossref_primary_10_1016_j_currproblcancer_2021_100834 crossref_primary_10_3892_ijo_2019_4909 crossref_primary_10_1155_2022_7889372 crossref_primary_10_1155_2018_8126208 crossref_primary_10_1016_j_gendis_2019_12_013 crossref_primary_10_1016_j_gande_2024_06_001 crossref_primary_10_1080_15384101_2022_2030167 crossref_primary_10_1038_s41598_022_05405_6 crossref_primary_10_3390_ijms23116200 crossref_primary_10_3389_fonc_2021_670838 crossref_primary_10_3390_bioengineering9080406 crossref_primary_10_1002_agj2_20804 crossref_primary_10_1002_jcb_29920 crossref_primary_10_1007_s00280_020_04120_1 crossref_primary_10_1016_j_repbio_2024_100893 crossref_primary_10_26508_lsa_202101139 crossref_primary_10_1016_j_phytochem_2023_113896 crossref_primary_10_1002_prca_202100031 crossref_primary_10_1007_s10238_023_01260_5 crossref_primary_10_1002_mc_22955 crossref_primary_10_3390_cancers13133209 crossref_primary_10_1007_s12072_019_09962_3 crossref_primary_10_2147_OTT_S252915 |
| Cites_doi | 10.1093/nar/gku1198 10.1093/bioinformatics/18.suppl_1.S96 10.18632/oncotarget.5158 10.1126/science.1192002 10.1007/s13277-014-2453-4 10.1053/j.gastro.2007.04.061 10.1038/nrc2826 10.1038/onc.2012.193 10.1002/cam4.220 10.3892/ol.2016.4130 10.3892/mmr.2017.7162 10.1111/j.2517-6161.1995.tb02031.x 10.1093/bioinformatics/btu638 10.1146/annurev-biochem-051410-092902 10.1038/onc.2016.75 10.1634/theoncologist.2010-S4-05 10.1128/JVI.00431-10 10.3389/fncel.2013.00168 10.1186/s12885-017-3431-1 10.1038/nprot.2008.211 10.1016/j.cell.2014.03.008 10.1038/nrg3074 10.12659/MSM.893528 10.1038/nprot.2013.092 10.3892/ijo.2014.2758 10.1016/j.canlet.2017.04.011 10.1016/j.jasms.2009.02.029 10.1093/nar/gku1003 10.18632/oncotarget.10065 10.1016/j.cell.2007.05.022 10.1097/MPA.0000000000000867 10.1038/nature08975 10.1016/j.celrep.2013.09.003 10.1186/1476-4598-13-92 10.1093/nar/gkw1138 10.1371/journal.pone.0051939 10.1007/s12032-011-0004-z 10.3390/ijms15034060 10.1245/s10434-011-1581-y 10.1038/nature10098 10.1158/0008-5472.CAN-14-1192 10.1074/jbc.M117.805655 10.1016/j.tibs.2011.12.003 10.1158/0008-5472.CAN-07-1922 10.1016/j.jhep.2015.05.016 10.1093/nar/gkq285 10.1002/mc.21944 10.1111/cas.12296 10.1038/ncomms3939 10.1158/0008-5472.CAN-11-1803 10.1074/mcp.M900628-MCP200 10.1091/mbc.e08-07-0681 10.1093/nar/gkv1145 10.1093/bioinformatics/btp120 10.1038/nprot.2013.143 10.1002/pmic.201300361 10.1101/gr.1239303 10.7150/ijbs.6339 10.1186/1476-4598-13-156 10.1186/1476-4598-7-5 10.1186/s13059-014-0550-8 10.1016/S0006-8993(02)04172-0 10.1074/mcp.M114.043984 10.3892/or.2012.2219 10.1093/nar/gkn923 10.1016/j.cell.2009.02.006 10.1177/147323001103900608 10.3892/ol.2016.5127 10.1002/pmic.201300393 10.1002/pmic.201400208 10.1093/nar/30.1.207 10.12659/MSM.894913 10.4161/rna.29624 |
| ContentType | Journal Article |
| Copyright | 2018 © 2018 by The American Society for Biochemistry and Molecular Biology, Inc. 2018 by The American Society for Biochemistry and Molecular Biology, Inc. Copyright American Society for Biochemistry and Molecular Biology Jan 2018 2018 by The American Society for Biochemistry and Molecular Biology, Inc. 2018 The American Society for Biochemistry and Molecular Biology, Inc. |
| Copyright_xml | – notice: 2018 © 2018 by The American Society for Biochemistry and Molecular Biology, Inc. – notice: 2018 by The American Society for Biochemistry and Molecular Biology, Inc. – notice: Copyright American Society for Biochemistry and Molecular Biology Jan 2018 – notice: 2018 by The American Society for Biochemistry and Molecular Biology, Inc. 2018 The American Society for Biochemistry and Molecular Biology, Inc. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 7TM 8FD FR3 P64 RC3 7X8 5PM |
| DOI | 10.1074/mcp.RA117.000277 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Nucleic Acids Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Engineering Research Database Biotechnology Research Abstracts Technology Research Database Nucleic Acids Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Biology |
| EISSN | 1535-9484 |
| EndPage | 159 |
| ExternalDocumentID | PMC5750844 29079719 10_1074_mcp_RA117_000277 S1535947620322908 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: ; grantid: 31370746; 91540102 |
| GroupedDBID | --- 0SF 123 18M 29M 2WC 34G 39C 4.4 53G 5VS 6I. AAEDW AAFTH AAFWJ AAXUO ABDNZ ACGFO ACIWK ACPRK ACYGS ADBBV AENEX AEXQZ AFPKN AFRAH ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BTFSW C1A CS3 DIK DU5 E3Z EBS EJD F5P FDB FRP GROUPED_DOAJ GX1 HH5 HYE KQ8 OK1 P2P RHF RHI RNS ROL RPM TBC TR2 W8F WOQ ZA5 0R~ AALRI AAYWO AAYXX ACVFH ADCNI ADVLN AEUPX AFPUW AIGII AITUG AKBMS AKRWK AKYEP CITATION H13 CGR CUY CVF ECM EIF NPM 7QO 7TM 8FD FR3 P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c541t-24d5ee3671a1092a8932dd9f14ad286efea96f65fcb15a69f70120382f681fff3 |
| ISSN | 1535-9476 1535-9484 |
| IngestDate | Thu Aug 21 18:18:21 EDT 2025 Fri Jul 11 02:28:00 EDT 2025 Mon Jun 30 12:00:12 EDT 2025 Thu Jan 02 22:56:53 EST 2025 Tue Jul 01 03:35:19 EDT 2025 Thu Apr 24 22:53:12 EDT 2025 Fri Feb 23 02:45:49 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This is an open access article under the CC BY license. 2018 by The American Society for Biochemistry and Molecular Biology, Inc. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c541t-24d5ee3671a1092a8932dd9f14ad286efea96f65fcb15a69f70120382f681fff3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work. Author contributions: Y.W., Q.X., and S.L. performed research; Y.W., Q.X., S.L., X.Y., and F.G. analyzed data; Y.W., Q.X., and F.G. wrote the paper; F.G. designed research. |
| OpenAccessLink | https://dx.doi.org/10.1074/mcp.RA117.000277 |
| PMID | 29079719 |
| PQID | 2006903063 |
| PQPubID | 2046230 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5750844 proquest_miscellaneous_1957485786 proquest_journals_2006903063 pubmed_primary_29079719 crossref_citationtrail_10_1074_mcp_RA117_000277 crossref_primary_10_1074_mcp_RA117_000277 elsevier_sciencedirect_doi_10_1074_mcp_RA117_000277 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-01-01 |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – month: 01 year: 2018 text: 2018-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Rockville |
| PublicationTitle | Molecular & cellular proteomics |
| PublicationTitleAlternate | Mol Cell Proteomics |
| PublicationYear | 2018 |
| Publisher | Elsevier Inc American Society for Biochemistry and Molecular Biology The American Society for Biochemistry and Molecular Biology |
| Publisher_xml | – name: Elsevier Inc – name: American Society for Biochemistry and Molecular Biology – name: The American Society for Biochemistry and Molecular Biology |
| References | Fu, Zhu, Wang, Lu, Hu, Wang, Liang, Wang, Ko, Waye, Kung, Li, Zhang (bib12) 2015; 63 Ono, Motoi, Nagano, Miyauchi, Ushijima, Matsuura, Okumura, Nishio, Hirose, Inase (bib39) 2014; 3 Lai, Yang, Zhou, Zhu, Xie, Zhang, Wu, Chen, Zheng (bib15) 2012; 29 Rinn, Kertesz, Wang, Squazzo, Xu, Brugmann, Goodnough, Helms, Farnham, Segal, Chang (bib16) 2007; 129 Kim, Jutooru, Chadalapaka, Johnson, Frank, Burghardt, Kim, Safe (bib40) 2013; 32 Schwanhausser, Busse, Li, Dittmar, Schuchhardt, Wolf, Chen, Selbach (bib41) 2011; 473 El-Serag, Rudolph (bib8) 2007; 132 Szklarczyk, Franceschini, Wyder, Forslund, Heller, Huerta-Cepas, Simonovic, Roth, Santos, Tsafou, Kuhn, Bork, Jensen, von Mering (bib63) 2015; 43 Ernst, Morton (bib5) 2013; 7 Hajjari, Salavaty (bib31) 2015; 12 Du, Wang, Jin, Wang, Ge, Lu, Ma, Chu, Tong, Zhu, Wang, Qiang, Zhang (bib24) 2015; 6 Yoon, Abdelmohsen, Kim, Yang, Martindale, Tominaga-Yamanaka, White, Orjalo, Rinn, Kreft, Wilson, Gorospe (bib35) 2013; 4 Trapnell, Pachter, Salzberg (bib44) 2009; 25 Yang, Zhou, Wu, Lai, Xie, Zhang, Zheng (bib10) 2011; 18 Armenta, Hoeschele, Lazar (bib54) 2009; 20 Ho, Zhou, Huang, Koirala, Xu, Fung, Wu, Mo (bib57) 2015; 43 Lee, Kim, Kim, Park, Chun, Cho, Song, Kim (bib19) 2016; 7 Huang da, Sherman, Lempicki (bib61) 2009; 37 Cheng, Zagon, Verderame, McLaughlin (bib68) 2007; 67 Coombs, Berard, Xu, Krokhin, Meng, Cortens, Kobasa, Wilkins, Brown (bib55) 2010; 84 Lee, Lee, Jung, Yi, Lee, Suh, Jang (bib71) 2017; 17 Han, Zhang, Chen, Shen, Zhou, Hu, Du, Tate, Huang, Zhang (bib56) 2014; 11 Ma, Zhang, Xue, Shah (bib72) 2017 Ge, Ma, Zheng, Ruan, Liao, Xue, Chen, Zhang, Jia (bib21) 2013; 104 Cech, Steitz (bib6) 2014; 157 Chen, Sun, Li, Wu, Ji, Liu, Zhou, Cao, Jin, Xie, Wang, Lv, De, Wu, Cao (bib20) 2013; 52 Venook, Papandreou, Furuse, de Guevara (bib9) 2010; 15 Liu, Sun, Nie, Ge, Zhang, Yin, Kong, Xia, Lu, Li, De, Wang, Wang (bib23) 2014; 13 Wu, Liu, Zheng, You, Kuang, Liu (bib79) 2014; 35 Shah, Sukumar (bib17) 2010; 10 Huang da, Sherman, Lempicki (bib62) 2009; 4 Cheng, McLaughlin, Verderame, Zagon (bib78) 2009; 20 Gao, Li, Du, Li (bib29) 2016; 11 Zagon, Kreiner, Heslop, Conway, Morgan, McLaughlin (bib69) 2008; 33 Wang, Liu, Wu, Ni, Gu, Qiao, Chen, Sun, Fan (bib13) 2010; 38 Tsai, Manor, Wan, Mosammaparast, Wang, Lan, Shi, Segal, Chang (bib33) 2010; 329 Zagon, Ruth, Leure-duPree, Sassani, McLaughlin (bib77) 2003; 967 Goyal, Myacheva, Gross, Klingenberg, Duran Arque, Diederichs (bib58) 2016; 45 Zagon, Donahue, McLaughlin (bib65) 2009; 297 Xu, Yu, Du, Yang, Dong, Huang, Yu, Cheng (bib22) 2013; 9 Salcedo Allende, Zeron-Medina, Hernandez, Macarulla, Balsells, Merino, Allende, Tabernero, Ramon (bib74) 2017; 46 Shannon, Markiel, Ozier, Baliga, Wang, Ramage, Amin, Schwikowski, Ideker (bib64) 2003; 13 Vizcaino, Csordas, del-Toro, Dianes, Griss, Lavidas, Mayer, Perez-Riverol, Reisinger, Ternent, Xu, Wang, Hermjakob (bib80) 2016; 44 Dong, Hu (bib27) 2016; 22 Ma, Li, Zhang, Weng, Zhang, Qin, Gong, Quan (bib34) 2014; 13 Kugel, Goodrich (bib2) 2012; 37 Wen, Li, Wright, Du, Feng, Xu, Choudhary, Wang (bib48) 2014; 14 Li, Liu, Wapinski, Tsai, Qu, Zhang, Carlson, Lin, Fang, Gupta (bib32) 2013; 5 Ponting, Oliver, Reik (bib3) 2009; 136 Geng, Xie, Li, Ma, Wang (bib28) 2011; 39 Anders, Pyl, Huber (bib45) 2015; 31 Niinuma, Suzuki, Nojima, Nosho, Yamamoto, Takamaru, Yamamoto, Maruyama, Nobuoka, Miyazaki, Nishida, Bamba, Kanda, Ajioka, Taguchi, Okahara, Takahashi, Nishida, Hosokawa, Hasegawa, Tokino, Hirata, Imai, Toyota, Shinomura (bib38) 2012; 72 Karp, Huber, Sadowski, Charles, Hester, Lilley (bib51) 2010; 9 Gupta, Shah, Wang, Kim, Horlings, Wong, Tsai, Hung, Argani, Rinn, Wang, Brzoska, Kong, Li, West, van de Vijver, Sukumar, Chang (bib7) 2010; 464 Donahue, McLaughlin, Zagon (bib66) 2009; 296 Ozes, Miller, Ozes, Fang, Liu, Matei, Huang, Nephew (bib26) 2016; 35 Mi, Huang, Muruganujan, Tang, Mills, Kang, Thomas (bib60) 2017; 45 Edgar, Domrachev, Lash (bib81) 2002; 30 Wen, Zhou, Feng, Wang, Wang, Liu (bib49) 2014; 14 Zheng, Xiong, Wu, Chen, Chen, Fleming, Gao, Bi, Ge (bib42) 2015; 14 Wen, Du, Li, Ghali, Jones, Kall, Xu, Zhou, Ren, Feng, Xu, Wang (bib47) 2015; 15 Avella, Kimchi, Donahue, Tagaram, McLaughlin, Zagon, Staveley-O'Carroll (bib76) 2010; 298 Cheng, McLaughlin, Verderame, Zagon (bib67) 2008; 7 Yiwei, Hua, Hui, Mao, Xiang (bib25) 2015; 21 Love, Huber, Anders (bib46) 2014; 15 Ishibashi, Kogo, Shibata, Sawada, Takahashi, Kurashige, Akiyoshi, Sasaki, Iwaya, Sudo, Sugimachi, Mimori, Wakabayashi, Mori (bib11) 2013; 29 Ou, Sun, Li, Li, Ren, Qin, Zhang, Yuan, Wang, Yu, Zhang, Peng, Yan, Xiong, Li, Ma (bib73) 2017; 399 Zhou, Cheng, He, Meng, Li, Chen (bib36) 2017; 16 Rinn, Chang (bib4) 2012; 81 Kim, Lee, Yim, Nam, Kim, Kim, Kim (bib18) 2015; 46 Kim, Jutooru, Chadalapaka, Johnson, Frank, Burghardt, Kim, Safe (bib70) 2012; 32 Su, Wu, Chen, He (bib37) 2016; 12 Ran, Hsu, Wright, Agarwala, Scott, Zhang (bib43) 2013; 8 Mi, Muruganujan, Casagrande, Thomas (bib59) 2013; 8 Huber, von Heydebreck, Sultmann, Poustka, Vingron (bib50) 2002; 18 Esteller (bib1) 2011; 12 Benjamini, Hochberg (bib52) 1995; 57 Ding, Cheng, Yang, Lv, Xiao, Du, Peng, Xie, Zhou, Wu, Zheng (bib30) 2014; 15 Cui, Xiao, Wang, Zheng, Song, Cai, Sun, Ye, Zhang (bib14) 2015; 75 Xia, Zeng, Zhu, Chen, Weng, Li (bib75) 2017 Berard, Cortens, Krokhin, Wilkins, Severini, Coombs (bib53) 2012; 7 Lee (10.1074/mcp.RA117.000277_bib19) 2016; 7 Rinn (10.1074/mcp.RA117.000277_bib16) 2007; 129 Wen (10.1074/mcp.RA117.000277_bib49) 2014; 14 Ge (10.1074/mcp.RA117.000277_bib21) 2013; 104 Cui (10.1074/mcp.RA117.000277_bib14) 2015; 75 Wang (10.1074/mcp.RA117.000277_bib13) 2010; 38 Xu (10.1074/mcp.RA117.000277_bib22) 2013; 9 Du (10.1074/mcp.RA117.000277_bib24) 2015; 6 Vizcaino (10.1074/mcp.RA117.000277_bib80) 2016; 44 Ono (10.1074/mcp.RA117.000277_bib39) 2014; 3 Schwanhausser (10.1074/mcp.RA117.000277_bib41) 2011; 473 Geng (10.1074/mcp.RA117.000277_bib28) 2011; 39 Hajjari (10.1074/mcp.RA117.000277_bib31) 2015; 12 Ernst (10.1074/mcp.RA117.000277_bib5) 2013; 7 Edgar (10.1074/mcp.RA117.000277_bib81) 2002; 30 Huang da (10.1074/mcp.RA117.000277_bib62) 2009; 4 Cheng (10.1074/mcp.RA117.000277_bib68) 2007; 67 Ma (10.1074/mcp.RA117.000277_bib34) 2014; 13 Yang (10.1074/mcp.RA117.000277_bib10) 2011; 18 Dong (10.1074/mcp.RA117.000277_bib27) 2016; 22 Huang da (10.1074/mcp.RA117.000277_bib61) 2009; 37 Kugel (10.1074/mcp.RA117.000277_bib2) 2012; 37 Cech (10.1074/mcp.RA117.000277_bib6) 2014; 157 Tsai (10.1074/mcp.RA117.000277_bib33) 2010; 329 Fu (10.1074/mcp.RA117.000277_bib12) 2015; 63 Han (10.1074/mcp.RA117.000277_bib56) 2014; 11 Zagon (10.1074/mcp.RA117.000277_bib77) 2003; 967 Niinuma (10.1074/mcp.RA117.000277_bib38) 2012; 72 Yoon (10.1074/mcp.RA117.000277_bib35) 2013; 4 Coombs (10.1074/mcp.RA117.000277_bib55) 2010; 84 Wen (10.1074/mcp.RA117.000277_bib48) 2014; 14 Li (10.1074/mcp.RA117.000277_bib32) 2013; 5 Zhou (10.1074/mcp.RA117.000277_bib36) 2017; 16 Kim (10.1074/mcp.RA117.000277_bib40) 2013; 32 Ran (10.1074/mcp.RA117.000277_bib43) 2013; 8 Goyal (10.1074/mcp.RA117.000277_bib58) 2016; 45 Cheng (10.1074/mcp.RA117.000277_bib67) 2008; 7 Zheng (10.1074/mcp.RA117.000277_bib42) 2015; 14 Zagon (10.1074/mcp.RA117.000277_bib65) 2009; 297 Ozes (10.1074/mcp.RA117.000277_bib26) 2016; 35 Esteller (10.1074/mcp.RA117.000277_bib1) 2011; 12 Wu (10.1074/mcp.RA117.000277_bib79) 2014; 35 Yiwei (10.1074/mcp.RA117.000277_bib25) 2015; 21 Shannon (10.1074/mcp.RA117.000277_bib64) 2003; 13 Benjamini (10.1074/mcp.RA117.000277_bib52) 1995; 57 Ou (10.1074/mcp.RA117.000277_bib73) 2017; 399 Wen (10.1074/mcp.RA117.000277_bib47) 2015; 15 Salcedo Allende (10.1074/mcp.RA117.000277_bib74) 2017; 46 Venook (10.1074/mcp.RA117.000277_bib9) 2010; 15 Huber (10.1074/mcp.RA117.000277_bib50) 2002; 18 Love (10.1074/mcp.RA117.000277_bib46) 2014; 15 Rinn (10.1074/mcp.RA117.000277_bib4) 2012; 81 Mi (10.1074/mcp.RA117.000277_bib59) 2013; 8 Xia (10.1074/mcp.RA117.000277_bib75) 2017 Donahue (10.1074/mcp.RA117.000277_bib66) 2009; 296 Shah (10.1074/mcp.RA117.000277_bib17) 2010; 10 Lai (10.1074/mcp.RA117.000277_bib15) 2012; 29 Ma (10.1074/mcp.RA117.000277_bib72) 2017 Berard (10.1074/mcp.RA117.000277_bib53) 2012; 7 Su (10.1074/mcp.RA117.000277_bib37) 2016; 12 Armenta (10.1074/mcp.RA117.000277_bib54) 2009; 20 Mi (10.1074/mcp.RA117.000277_bib60) 2017; 45 Liu (10.1074/mcp.RA117.000277_bib23) 2014; 13 Avella (10.1074/mcp.RA117.000277_bib76) 2010; 298 Ponting (10.1074/mcp.RA117.000277_bib3) 2009; 136 Ding (10.1074/mcp.RA117.000277_bib30) 2014; 15 Trapnell (10.1074/mcp.RA117.000277_bib44) 2009; 25 Gupta (10.1074/mcp.RA117.000277_bib7) 2010; 464 Kim (10.1074/mcp.RA117.000277_bib70) 2012; 32 Anders (10.1074/mcp.RA117.000277_bib45) 2015; 31 El-Serag (10.1074/mcp.RA117.000277_bib8) 2007; 132 Chen (10.1074/mcp.RA117.000277_bib20) 2013; 52 Ho (10.1074/mcp.RA117.000277_bib57) 2015; 43 Szklarczyk (10.1074/mcp.RA117.000277_bib63) 2015; 43 Gao (10.1074/mcp.RA117.000277_bib29) 2016; 11 Ishibashi (10.1074/mcp.RA117.000277_bib11) 2013; 29 Cheng (10.1074/mcp.RA117.000277_bib78) 2009; 20 Kim (10.1074/mcp.RA117.000277_bib18) 2015; 46 Karp (10.1074/mcp.RA117.000277_bib51) 2010; 9 Zagon (10.1074/mcp.RA117.000277_bib69) 2008; 33 Lee (10.1074/mcp.RA117.000277_bib71) 2017; 17 |
| References_xml | – volume: 45 start-page: D183 year: 2017 end-page: D189 ident: bib60 article-title: PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements publication-title: Nucleic Acids Res – volume: 4 start-page: 2939 year: 2013 ident: bib35 article-title: Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination publication-title: Nature Commun – volume: 72 start-page: 1126 year: 2012 end-page: 1136 ident: bib38 article-title: Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors publication-title: Cancer Res – volume: 37 start-page: 1 year: 2009 end-page: 13 ident: bib61 article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists publication-title: Nucleic Acids Res – volume: 297 start-page: R1154 year: 2009 end-page: R1161 ident: bib65 article-title: Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers publication-title: Am. J. Physiol.-Reg I – volume: 298 start-page: R459 year: 2010 end-page: R466 ident: bib76 article-title: The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer publication-title: Am. J. Physiol.-Reg I – volume: 16 start-page: 4980 year: 2017 end-page: 4986 ident: bib36 article-title: Knockdown of Hotair suppresses proliferation and cell cycle progression in hepatocellular carcinoma cell by downregulating CCND1 expression publication-title: Mol. Med. Reports – volume: 11 start-page: 829 year: 2014 end-page: 835 ident: bib56 article-title: Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9 publication-title: RNA Biol – volume: 29 start-page: 946 year: 2013 end-page: 950 ident: bib11 article-title: Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma publication-title: Oncol. Reports – volume: 46 start-page: 521 year: 2015 end-page: 530 ident: bib18 article-title: Long non-coding RNA HOTAIR is associated with human cervical cancer progression publication-title: Int. J. Oncol – volume: 7 start-page: 168 year: 2013 ident: bib5 article-title: Identification and function of long non-coding RNA publication-title: Front. Cell. Neurosci – year: 2017 ident: bib72 article-title: Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity publication-title: J. Biol. Chem – volume: 8 start-page: 2281 year: 2013 end-page: 2308 ident: bib43 article-title: Genome engineering using the CRISPR-Cas9 system publication-title: Nat. Protocols – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib52 article-title: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing publication-title: J. Roy. Statistical Soc – volume: 75 start-page: 846 year: 2015 end-page: 857 ident: bib14 article-title: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway publication-title: Cancer Res – volume: 329 start-page: 689 year: 2010 end-page: 693 ident: bib33 article-title: Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes publication-title: Science – volume: 46 start-page: 913 year: 2017 end-page: 920 ident: bib74 article-title: Overexpression of Yes associated protein 1, an independent prognostic marker in patients with pancreatic ductal adenocarcinoma, correlated with liver metastasis and poor prognosis publication-title: Pancreas – volume: 52 start-page: 908 year: 2013 end-page: 915 ident: bib20 article-title: Upregulation of the Long Non-Coding RNA HOTAIR Promotes Esophageal Squamous Cell Carcinoma Metastasis and Poor Prognosis publication-title: Mol. Carcinogen – volume: 33 start-page: 317 year: 2008 end-page: 323 ident: bib69 article-title: Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor publication-title: Int. J. Oncol – volume: 39 start-page: 2119 year: 2011 end-page: 2128 ident: bib28 article-title: Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression publication-title: J. Int.Med. Res – volume: 12 start-page: 4061 year: 2016 end-page: 4067 ident: bib37 article-title: HOTAIR, a long non-coding RNA driver of malignancy whose expression is activated by FOXC1, negatively regulates miRNA-1 in hepatocellular carcinoma publication-title: Oncol. Lett – volume: 13 start-page: 2498 year: 2003 end-page: 2504 ident: bib64 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res – volume: 15 start-page: 2916 year: 2015 end-page: 2920 ident: bib47 article-title: IPeak: An open source tool to combine results from multiple MS/MS search engines publication-title: Proteomics – volume: 967 start-page: 37 year: 2003 end-page: 47 ident: bib77 article-title: Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea publication-title: Brain Res – volume: 22 start-page: 325 year: 2016 end-page: 331 ident: bib27 article-title: HOTAIR Promotes Proliferation, Migration, and Invasion of Ovarian Cancer SKOV3 Cells Through Regulating PIK3R3 publication-title: Med. Sci. Monitor – volume: 13 start-page: 156 year: 2014 ident: bib34 article-title: Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer publication-title: Mol. Cancer – volume: 63 start-page: 886 year: 2015 end-page: 895 ident: bib12 article-title: Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling publication-title: J. Hepatol – volume: 67 start-page: 10511 year: 2007 end-page: 10518 ident: bib68 article-title: The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer publication-title: Cancer Res – volume: 32 start-page: 1616 year: 2012 end-page: 1625 ident: bib70 article-title: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer publication-title: Oncogene – volume: 136 start-page: 629 year: 2009 end-page: 641 ident: bib3 article-title: Evolution and functions of long noncoding RNAs publication-title: Cell – volume: 8 start-page: 1551 year: 2013 end-page: 1566 ident: bib59 article-title: Large-scale gene function analysis with the PANTHER classification system publication-title: Nat. Protocols – volume: 14 start-page: 1447 year: 2015 end-page: 1463 ident: bib42 article-title: Quantitative proteomics analysis reveals novel insights into mechanisms of action of long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) in HeLa cells publication-title: Mol. Cell. Proteomics – volume: 18 start-page: S96 year: 2002 end-page: 104 ident: bib50 article-title: Variance stabilization applied to microarray data calibration and to the quantification of differential expression publication-title: Bioinformatics – volume: 132 start-page: 2557 year: 2007 end-page: 2576 ident: bib8 article-title: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis publication-title: Gastroenterology – volume: 296 start-page: R1716 year: 2009 end-page: R1725 ident: bib66 article-title: Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis publication-title: Am. J. Physiol.-Reg I – volume: 5 start-page: 3 year: 2013 end-page: 12 ident: bib32 article-title: Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression publication-title: Cell Reports – volume: 84 start-page: 10888 year: 2010 end-page: 10906 ident: bib55 article-title: Quantitative proteomic analyses of influenza virus-infected cultured human lung cells publication-title: J. Virol – volume: 399 start-page: 53 year: 2017 end-page: 63 ident: bib73 article-title: MiR-590–5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer publication-title: Cancer Lett – volume: 9 start-page: 587 year: 2013 end-page: 597 ident: bib22 article-title: Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer publication-title: Int. J. Biol. Sci – volume: 32 start-page: 1616 year: 2013 end-page: 1625 ident: bib40 article-title: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer publication-title: Oncogene – volume: 44 start-page: D447 year: 2016 end-page: D456 ident: bib80 article-title: 2016 update of the PRIDE database and its related tools publication-title: Nucleic Acids Res – volume: 6 start-page: 31255 year: 2015 end-page: 31262 ident: bib24 article-title: The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population publication-title: Oncotarget – volume: 25 start-page: 1105 year: 2009 end-page: 1111 ident: bib44 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics – volume: 20 start-page: 1287 year: 2009 end-page: 1302 ident: bib54 article-title: Differential Protein Expression Analysis Using Stable Isotope Labeling and PQD Linear Ion Trap MS Technology publication-title: J. Am. Soc. Mass Spectrom – volume: 464 start-page: U1071 year: 2010 end-page: U1148 ident: bib7 article-title: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis publication-title: Nature – volume: 18 start-page: 1243 year: 2011 end-page: 1250 ident: bib10 article-title: Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation publication-title: Ann. Surg. Oncol – year: 2017 ident: bib75 article-title: Emerging role of Hippo signalling pathway in bladder cancer publication-title: J. Cell. Mol. Med – volume: 17 start-page: 441 year: 2017 ident: bib71 article-title: The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas publication-title: BMC Cancer – volume: 13 start-page: 92 year: 2014 ident: bib23 article-title: Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331–3p in gastric cancer publication-title: Mol. Cancer – volume: 9 start-page: 1885 year: 2010 end-page: 1897 ident: bib51 article-title: Addressing accuracy and precision issues in iTRAQ quantitation publication-title: Mol. Cell. Proteomics – volume: 29 start-page: 1810 year: 2012 end-page: 1816 ident: bib15 article-title: Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation publication-title: Med. Oncol – volume: 43 start-page: e17 year: 2015 ident: bib57 article-title: Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines publication-title: Nucleic Acids Res – volume: 3 start-page: 632 year: 2014 end-page: 642 ident: bib39 article-title: Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer publication-title: Cancer Med – volume: 35 start-page: 5350 year: 2016 end-page: 5361 ident: bib26 article-title: NF-kappaB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer publication-title: Oncogene – volume: 35 start-page: 11887 year: 2014 end-page: 11894 ident: bib79 article-title: Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells publication-title: Tumour Biol – volume: 81 start-page: 145 year: 2012 end-page: 166 ident: bib4 article-title: Genome regulation by long noncoding RNAs publication-title: Ann. Rev. Biochem – volume: 21 start-page: 1856 year: 2015 end-page: 1863 ident: bib25 article-title: HOTAIR Interacting with MAPK1 regulates ovarian cancer skov3 cell proliferation, migration, and invasion publication-title: Med. Sci. Monitor – volume: 14 start-page: 1011 year: 2014 end-page: 1014 ident: bib48 article-title: The OMSSAPercolator: an automated tool to validate OMSSA results publication-title: Proteomics – volume: 7 start-page: 44558 year: 2016 end-page: 44571 ident: bib19 article-title: The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway publication-title: Oncotarget – volume: 43 start-page: D447 year: 2015 end-page: D452 ident: bib63 article-title: STRING v10: protein-protein interaction networks, integrated over the tree of life publication-title: Nucleic Acids Res – volume: 129 start-page: 1311 year: 2007 end-page: 1323 ident: bib16 article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs publication-title: Cell – volume: 45 start-page: e12 year: 2016 ident: bib58 article-title: Challenges of CRISPR/Cas9 applications for long non-coding RNA genes publication-title: Nucleic Acids Res – volume: 7 year: 2008 ident: bib67 article-title: The OGF-OGFr axis uses the p21 pathway to restrict progression of human pancreatic cancer publication-title: Molecular cancer – volume: 30 start-page: 207 year: 2002 end-page: 210 ident: bib81 article-title: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository publication-title: Nucleic Acids Res – volume: 104 start-page: 1675 year: 2013 end-page: 1682 ident: bib21 article-title: HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway publication-title: Cancer Sci – volume: 38 start-page: 5366 year: 2010 end-page: 5383 ident: bib13 article-title: CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer publication-title: Nucleic Acids Res – volume: 12 start-page: 1 year: 2015 end-page: 9 ident: bib31 article-title: HOTAIR: an oncogenic long non-coding RNA in different cancers publication-title: Cancer Biol. Med – volume: 31 start-page: 166 year: 2015 end-page: 169 ident: bib45 article-title: HTSeq-a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics – volume: 14 start-page: 2280 year: 2014 end-page: 2285 ident: bib49 article-title: IQuant: an automated pipeline for quantitative proteomics based upon isobaric tags publication-title: Proteomics – volume: 15 start-page: 5 year: 2010 end-page: 13 ident: bib9 article-title: The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective publication-title: Oncologist – volume: 11 start-page: 1791 year: 2016 end-page: 1798 ident: bib29 article-title: Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence publication-title: Oncol. Lett – volume: 15 start-page: 550 year: 2014 ident: bib46 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol – volume: 4 start-page: 44 year: 2009 end-page: 57 ident: bib62 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nature Protocols – volume: 12 start-page: 861 year: 2011 end-page: 874 ident: bib1 article-title: Non-coding RNAs in human disease publication-title: Nat. Rev. Genet – volume: 7 start-page: e51939 year: 2012 ident: bib53 article-title: Quantification of the host response proteome after mammalian reovirus T1L infection publication-title: PLoS ONE – volume: 157 start-page: 77 year: 2014 end-page: 94 ident: bib6 article-title: The noncoding RNA revolution-trashing old rules to forge new ones publication-title: Cell – volume: 10 start-page: 361 year: 2010 end-page: 371 ident: bib17 article-title: The Hox genes and their roles in oncogenesis publication-title: Nat. Rev. Cancer – volume: 473 start-page: 337 year: 2011 end-page: 342 ident: bib41 article-title: Global quantification of mammalian gene expression control publication-title: Nature – volume: 37 start-page: 144 year: 2012 end-page: 151 ident: bib2 article-title: Non-coding RNAs: key regulators of mammalian transcription publication-title: Trends Biochem. Sci – volume: 15 start-page: 4060 year: 2014 end-page: 4076 ident: bib30 article-title: Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells publication-title: Int. J. Mol. Sci – volume: 20 start-page: 319 year: 2009 end-page: 327 ident: bib78 article-title: The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation publication-title: Mol. Biol. Cell – volume: 43 start-page: e17 year: 2015 ident: 10.1074/mcp.RA117.000277_bib57 article-title: Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines publication-title: Nucleic Acids Res doi: 10.1093/nar/gku1198 – volume: 18 start-page: S96 year: 2002 ident: 10.1074/mcp.RA117.000277_bib50 article-title: Variance stabilization applied to microarray data calibration and to the quantification of differential expression publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.suppl_1.S96 – volume: 6 start-page: 31255 year: 2015 ident: 10.1074/mcp.RA117.000277_bib24 article-title: The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population publication-title: Oncotarget doi: 10.18632/oncotarget.5158 – volume: 329 start-page: 689 year: 2010 ident: 10.1074/mcp.RA117.000277_bib33 article-title: Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes publication-title: Science doi: 10.1126/science.1192002 – volume: 35 start-page: 11887 year: 2014 ident: 10.1074/mcp.RA117.000277_bib79 article-title: Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells publication-title: Tumour Biol doi: 10.1007/s13277-014-2453-4 – volume: 132 start-page: 2557 year: 2007 ident: 10.1074/mcp.RA117.000277_bib8 article-title: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.04.061 – volume: 10 start-page: 361 year: 2010 ident: 10.1074/mcp.RA117.000277_bib17 article-title: The Hox genes and their roles in oncogenesis publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2826 – volume: 32 start-page: 1616 year: 2012 ident: 10.1074/mcp.RA117.000277_bib70 article-title: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer publication-title: Oncogene doi: 10.1038/onc.2012.193 – volume: 3 start-page: 632 year: 2014 ident: 10.1074/mcp.RA117.000277_bib39 article-title: Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer publication-title: Cancer Med doi: 10.1002/cam4.220 – volume: 11 start-page: 1791 year: 2016 ident: 10.1074/mcp.RA117.000277_bib29 article-title: Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence publication-title: Oncol. Lett doi: 10.3892/ol.2016.4130 – volume: 16 start-page: 4980 year: 2017 ident: 10.1074/mcp.RA117.000277_bib36 article-title: Knockdown of Hotair suppresses proliferation and cell cycle progression in hepatocellular carcinoma cell by downregulating CCND1 expression publication-title: Mol. Med. Reports doi: 10.3892/mmr.2017.7162 – volume: 57 start-page: 289 year: 1995 ident: 10.1074/mcp.RA117.000277_bib52 article-title: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing publication-title: J. Roy. Statistical Soc doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 31 start-page: 166 year: 2015 ident: 10.1074/mcp.RA117.000277_bib45 article-title: HTSeq-a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu638 – volume: 81 start-page: 145 year: 2012 ident: 10.1074/mcp.RA117.000277_bib4 article-title: Genome regulation by long noncoding RNAs publication-title: Ann. Rev. Biochem doi: 10.1146/annurev-biochem-051410-092902 – volume: 35 start-page: 5350 year: 2016 ident: 10.1074/mcp.RA117.000277_bib26 article-title: NF-kappaB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer publication-title: Oncogene doi: 10.1038/onc.2016.75 – volume: 15 start-page: 5 year: 2010 ident: 10.1074/mcp.RA117.000277_bib9 article-title: The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective publication-title: Oncologist doi: 10.1634/theoncologist.2010-S4-05 – volume: 84 start-page: 10888 year: 2010 ident: 10.1074/mcp.RA117.000277_bib55 article-title: Quantitative proteomic analyses of influenza virus-infected cultured human lung cells publication-title: J. Virol doi: 10.1128/JVI.00431-10 – volume: 7 start-page: 168 year: 2013 ident: 10.1074/mcp.RA117.000277_bib5 article-title: Identification and function of long non-coding RNA publication-title: Front. Cell. Neurosci doi: 10.3389/fncel.2013.00168 – volume: 17 start-page: 441 year: 2017 ident: 10.1074/mcp.RA117.000277_bib71 article-title: The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas publication-title: BMC Cancer doi: 10.1186/s12885-017-3431-1 – volume: 4 start-page: 44 year: 2009 ident: 10.1074/mcp.RA117.000277_bib62 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nature Protocols doi: 10.1038/nprot.2008.211 – volume: 157 start-page: 77 year: 2014 ident: 10.1074/mcp.RA117.000277_bib6 article-title: The noncoding RNA revolution-trashing old rules to forge new ones publication-title: Cell doi: 10.1016/j.cell.2014.03.008 – volume: 12 start-page: 861 year: 2011 ident: 10.1074/mcp.RA117.000277_bib1 article-title: Non-coding RNAs in human disease publication-title: Nat. Rev. Genet doi: 10.1038/nrg3074 – volume: 32 start-page: 1616 year: 2013 ident: 10.1074/mcp.RA117.000277_bib40 article-title: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer publication-title: Oncogene doi: 10.1038/onc.2012.193 – volume: 21 start-page: 1856 year: 2015 ident: 10.1074/mcp.RA117.000277_bib25 article-title: HOTAIR Interacting with MAPK1 regulates ovarian cancer skov3 cell proliferation, migration, and invasion publication-title: Med. Sci. Monitor doi: 10.12659/MSM.893528 – volume: 8 start-page: 1551 year: 2013 ident: 10.1074/mcp.RA117.000277_bib59 article-title: Large-scale gene function analysis with the PANTHER classification system publication-title: Nat. Protocols doi: 10.1038/nprot.2013.092 – volume: 46 start-page: 521 year: 2015 ident: 10.1074/mcp.RA117.000277_bib18 article-title: Long non-coding RNA HOTAIR is associated with human cervical cancer progression publication-title: Int. J. Oncol doi: 10.3892/ijo.2014.2758 – volume: 399 start-page: 53 year: 2017 ident: 10.1074/mcp.RA117.000277_bib73 article-title: MiR-590–5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer publication-title: Cancer Lett doi: 10.1016/j.canlet.2017.04.011 – volume: 20 start-page: 1287 year: 2009 ident: 10.1074/mcp.RA117.000277_bib54 article-title: Differential Protein Expression Analysis Using Stable Isotope Labeling and PQD Linear Ion Trap MS Technology publication-title: J. Am. Soc. Mass Spectrom doi: 10.1016/j.jasms.2009.02.029 – volume: 43 start-page: D447 year: 2015 ident: 10.1074/mcp.RA117.000277_bib63 article-title: STRING v10: protein-protein interaction networks, integrated over the tree of life publication-title: Nucleic Acids Res doi: 10.1093/nar/gku1003 – volume: 7 start-page: 44558 year: 2016 ident: 10.1074/mcp.RA117.000277_bib19 article-title: The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway publication-title: Oncotarget doi: 10.18632/oncotarget.10065 – volume: 129 start-page: 1311 year: 2007 ident: 10.1074/mcp.RA117.000277_bib16 article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs publication-title: Cell doi: 10.1016/j.cell.2007.05.022 – volume: 46 start-page: 913 year: 2017 ident: 10.1074/mcp.RA117.000277_bib74 article-title: Overexpression of Yes associated protein 1, an independent prognostic marker in patients with pancreatic ductal adenocarcinoma, correlated with liver metastasis and poor prognosis publication-title: Pancreas doi: 10.1097/MPA.0000000000000867 – volume: 464 start-page: U1071 year: 2010 ident: 10.1074/mcp.RA117.000277_bib7 article-title: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis publication-title: Nature doi: 10.1038/nature08975 – volume: 5 start-page: 3 year: 2013 ident: 10.1074/mcp.RA117.000277_bib32 article-title: Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression publication-title: Cell Reports doi: 10.1016/j.celrep.2013.09.003 – volume: 13 start-page: 92 year: 2014 ident: 10.1074/mcp.RA117.000277_bib23 article-title: Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331–3p in gastric cancer publication-title: Mol. Cancer doi: 10.1186/1476-4598-13-92 – volume: 45 start-page: D183 year: 2017 ident: 10.1074/mcp.RA117.000277_bib60 article-title: PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements publication-title: Nucleic Acids Res doi: 10.1093/nar/gkw1138 – volume: 7 start-page: e51939 year: 2012 ident: 10.1074/mcp.RA117.000277_bib53 article-title: Quantification of the host response proteome after mammalian reovirus T1L infection publication-title: PLoS ONE doi: 10.1371/journal.pone.0051939 – volume: 29 start-page: 1810 year: 2012 ident: 10.1074/mcp.RA117.000277_bib15 article-title: Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation publication-title: Med. Oncol doi: 10.1007/s12032-011-0004-z – volume: 15 start-page: 4060 year: 2014 ident: 10.1074/mcp.RA117.000277_bib30 article-title: Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells publication-title: Int. J. Mol. Sci doi: 10.3390/ijms15034060 – volume: 18 start-page: 1243 year: 2011 ident: 10.1074/mcp.RA117.000277_bib10 article-title: Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation publication-title: Ann. Surg. Oncol doi: 10.1245/s10434-011-1581-y – volume: 473 start-page: 337 year: 2011 ident: 10.1074/mcp.RA117.000277_bib41 article-title: Global quantification of mammalian gene expression control publication-title: Nature doi: 10.1038/nature10098 – volume: 75 start-page: 846 year: 2015 ident: 10.1074/mcp.RA117.000277_bib14 article-title: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-14-1192 – year: 2017 ident: 10.1074/mcp.RA117.000277_bib72 article-title: Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity publication-title: J. Biol. Chem doi: 10.1074/jbc.M117.805655 – volume: 37 start-page: 144 year: 2012 ident: 10.1074/mcp.RA117.000277_bib2 article-title: Non-coding RNAs: key regulators of mammalian transcription publication-title: Trends Biochem. Sci doi: 10.1016/j.tibs.2011.12.003 – volume: 67 start-page: 10511 year: 2007 ident: 10.1074/mcp.RA117.000277_bib68 article-title: The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-1922 – volume: 63 start-page: 886 year: 2015 ident: 10.1074/mcp.RA117.000277_bib12 article-title: Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling publication-title: J. Hepatol doi: 10.1016/j.jhep.2015.05.016 – volume: 38 start-page: 5366 year: 2010 ident: 10.1074/mcp.RA117.000277_bib13 article-title: CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq285 – volume: 52 start-page: 908 year: 2013 ident: 10.1074/mcp.RA117.000277_bib20 article-title: Upregulation of the Long Non-Coding RNA HOTAIR Promotes Esophageal Squamous Cell Carcinoma Metastasis and Poor Prognosis publication-title: Mol. Carcinogen doi: 10.1002/mc.21944 – volume: 104 start-page: 1675 year: 2013 ident: 10.1074/mcp.RA117.000277_bib21 article-title: HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway publication-title: Cancer Sci doi: 10.1111/cas.12296 – volume: 4 start-page: 2939 year: 2013 ident: 10.1074/mcp.RA117.000277_bib35 article-title: Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination publication-title: Nature Commun doi: 10.1038/ncomms3939 – year: 2017 ident: 10.1074/mcp.RA117.000277_bib75 article-title: Emerging role of Hippo signalling pathway in bladder cancer publication-title: J. Cell. Mol. Med – volume: 72 start-page: 1126 year: 2012 ident: 10.1074/mcp.RA117.000277_bib38 article-title: Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-1803 – volume: 298 start-page: R459 year: 2010 ident: 10.1074/mcp.RA117.000277_bib76 article-title: The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer publication-title: Am. J. Physiol.-Reg I – volume: 9 start-page: 1885 year: 2010 ident: 10.1074/mcp.RA117.000277_bib51 article-title: Addressing accuracy and precision issues in iTRAQ quantitation publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M900628-MCP200 – volume: 20 start-page: 319 year: 2009 ident: 10.1074/mcp.RA117.000277_bib78 article-title: The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e08-07-0681 – volume: 44 start-page: D447 year: 2016 ident: 10.1074/mcp.RA117.000277_bib80 article-title: 2016 update of the PRIDE database and its related tools publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv1145 – volume: 25 start-page: 1105 year: 2009 ident: 10.1074/mcp.RA117.000277_bib44 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 8 start-page: 2281 year: 2013 ident: 10.1074/mcp.RA117.000277_bib43 article-title: Genome engineering using the CRISPR-Cas9 system publication-title: Nat. Protocols doi: 10.1038/nprot.2013.143 – volume: 14 start-page: 2280 year: 2014 ident: 10.1074/mcp.RA117.000277_bib49 article-title: IQuant: an automated pipeline for quantitative proteomics based upon isobaric tags publication-title: Proteomics doi: 10.1002/pmic.201300361 – volume: 13 start-page: 2498 year: 2003 ident: 10.1074/mcp.RA117.000277_bib64 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res doi: 10.1101/gr.1239303 – volume: 9 start-page: 587 year: 2013 ident: 10.1074/mcp.RA117.000277_bib22 article-title: Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer publication-title: Int. J. Biol. Sci doi: 10.7150/ijbs.6339 – volume: 13 start-page: 156 year: 2014 ident: 10.1074/mcp.RA117.000277_bib34 article-title: Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer publication-title: Mol. Cancer doi: 10.1186/1476-4598-13-156 – volume: 7 year: 2008 ident: 10.1074/mcp.RA117.000277_bib67 article-title: The OGF-OGFr axis uses the p21 pathway to restrict progression of human pancreatic cancer publication-title: Molecular cancer doi: 10.1186/1476-4598-7-5 – volume: 15 start-page: 550 year: 2014 ident: 10.1074/mcp.RA117.000277_bib46 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 – volume: 967 start-page: 37 year: 2003 ident: 10.1074/mcp.RA117.000277_bib77 article-title: Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea publication-title: Brain Res doi: 10.1016/S0006-8993(02)04172-0 – volume: 14 start-page: 1447 year: 2015 ident: 10.1074/mcp.RA117.000277_bib42 article-title: Quantitative proteomics analysis reveals novel insights into mechanisms of action of long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) in HeLa cells publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M114.043984 – volume: 29 start-page: 946 year: 2013 ident: 10.1074/mcp.RA117.000277_bib11 article-title: Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma publication-title: Oncol. Reports doi: 10.3892/or.2012.2219 – volume: 37 start-page: 1 year: 2009 ident: 10.1074/mcp.RA117.000277_bib61 article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn923 – volume: 296 start-page: R1716 year: 2009 ident: 10.1074/mcp.RA117.000277_bib66 article-title: Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis publication-title: Am. J. Physiol.-Reg I – volume: 136 start-page: 629 year: 2009 ident: 10.1074/mcp.RA117.000277_bib3 article-title: Evolution and functions of long noncoding RNAs publication-title: Cell doi: 10.1016/j.cell.2009.02.006 – volume: 39 start-page: 2119 year: 2011 ident: 10.1074/mcp.RA117.000277_bib28 article-title: Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression publication-title: J. Int.Med. Res doi: 10.1177/147323001103900608 – volume: 12 start-page: 4061 year: 2016 ident: 10.1074/mcp.RA117.000277_bib37 article-title: HOTAIR, a long non-coding RNA driver of malignancy whose expression is activated by FOXC1, negatively regulates miRNA-1 in hepatocellular carcinoma publication-title: Oncol. Lett doi: 10.3892/ol.2016.5127 – volume: 14 start-page: 1011 year: 2014 ident: 10.1074/mcp.RA117.000277_bib48 article-title: The OMSSAPercolator: an automated tool to validate OMSSA results publication-title: Proteomics doi: 10.1002/pmic.201300393 – volume: 33 start-page: 317 year: 2008 ident: 10.1074/mcp.RA117.000277_bib69 article-title: Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor publication-title: Int. J. Oncol – volume: 15 start-page: 2916 year: 2015 ident: 10.1074/mcp.RA117.000277_bib47 article-title: IPeak: An open source tool to combine results from multiple MS/MS search engines publication-title: Proteomics doi: 10.1002/pmic.201400208 – volume: 12 start-page: 1 year: 2015 ident: 10.1074/mcp.RA117.000277_bib31 article-title: HOTAIR: an oncogenic long non-coding RNA in different cancers publication-title: Cancer Biol. Med – volume: 45 start-page: e12 year: 2016 ident: 10.1074/mcp.RA117.000277_bib58 article-title: Challenges of CRISPR/Cas9 applications for long non-coding RNA genes publication-title: Nucleic Acids Res – volume: 30 start-page: 207 year: 2002 ident: 10.1074/mcp.RA117.000277_bib81 article-title: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository publication-title: Nucleic Acids Res doi: 10.1093/nar/30.1.207 – volume: 22 start-page: 325 year: 2016 ident: 10.1074/mcp.RA117.000277_bib27 article-title: HOTAIR Promotes Proliferation, Migration, and Invasion of Ovarian Cancer SKOV3 Cells Through Regulating PIK3R3 publication-title: Med. Sci. Monitor doi: 10.12659/MSM.894913 – volume: 11 start-page: 829 year: 2014 ident: 10.1074/mcp.RA117.000277_bib56 article-title: Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9 publication-title: RNA Biol doi: 10.4161/rna.29624 – volume: 297 start-page: R1154 year: 2009 ident: 10.1074/mcp.RA117.000277_bib65 article-title: Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers publication-title: Am. J. Physiol.-Reg I |
| SSID | ssj0020175 |
| Score | 2.404676 |
| Snippet | Long noncoding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 146 |
| SubjectTerms | Antisense RNA Bioinformatics Biological activity Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell growth Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Growth factors Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Molecular modelling Narcotics Opioid growth factor Opioid receptors Polymerase chain reaction Proteins Proteomics Receptors, Opioid - genetics Receptors, Opioid - metabolism Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signaling Transcription Tumorigenesis |
| Title | Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr) |
| URI | https://dx.doi.org/10.1074/mcp.RA117.000277 https://www.ncbi.nlm.nih.gov/pubmed/29079719 https://www.proquest.com/docview/2006903063 https://www.proquest.com/docview/1957485786 https://pubmed.ncbi.nlm.nih.gov/PMC5750844 |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2ISReEGx8FAYyEkIbVbY5n85jmVY6VFooneieoiS1WSSWVmsKGn8vfwh3duImG0zAS1Q5duLm7uf78PmOkJd-EOP-lLBAWXYtl8euxW0hLZmwhMXTUDKO553fD_zeiftu4k3W1l_XopaWRbKX_vjtuZL_oSq0AV3xlOw_UNY8FBrgN9AXrkBhuP4VjY-rXA8q4L8QeMJY7QYoCaTWA9VkMo-MxDeB-ZL7WGFoMMvTmTrTMhp02r3hpDYMkwpkCzBxy9BKmAJG3EM_0Eh7w3HneIT-hA8qmE8sQHrNwXrHXQAV1nqIFYry2XncPlS-QSwNJEXJbAmq_V9U2TB493CezTLlFPtenLW7qvwPKrNiXqjaH3z4tntR-Suq0lNVTV_FuOat8-obGDvh81KJmEo8Q8skw7_-sQaKftb-lBW1LqelC32yFHWfCONXfCJms6se-fomwxJkuoaeDmIxc9VlPy8bYsCzQjcok3TX23RBOyM7gmsY0YKgcqxqnYLprOfXxBXob8Bj5-l8b9RhTCXTtMuqNo3M4INh1D3p96Px0WS8Tm5BH2UM9HqrvJKwsno6N7CeebklD2_Yv_r8P6lg102sq5HCNdVrfI_cLW0m2tEAuE_WRL5JtoCpgbsv6SuqopjVt90kt8uvvEV-rtBBDTookIQ20UErdNASHRTRQQ06KHA9BXTUhlGDDrpCh-q3o7GxSytk0CYyqEEGRWTQBjJocklXyKAaGVQjg2pk0AoZdAdxsfuAnHSPxoc9q6xpYqWeywrLdqeeEI4fsJgdhHYM5oI9xSXRjac294UUcehL35NpwrzYD2WAp9sdbkufMyml85Bs5LNcPCZ0mnApbR_PgjuwyPLQE5hOMXV4bAdJ4LXIfkXmKC0T_mPdma-RCjwJ3AgYI1KMEWnGaJFdM2Kuk93c0NepOCcqlXWthEfA3DeM2q6YLCoX0gVWwvVD9F04LfLC3AakIm3iXMyWi4iFXuByUC_8FnmkedJM0Q4PgjBgYYsEDW41HTCFfvNOnp2pVPpgrB5w131y87SekjurVWabbBQXS_EMbJEiea5A-AvJ_z3z |
| linkProvider | ABC ChemistRy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integrated+Proteomic+and+Transcriptomic+Analysis+Reveals+Long+Noncoding+RNA+HOX+Transcript+Antisense+Intergenic+RNA+%28HOTAIR%29+Promotes+Hepatocellular+Carcinoma+Cell+Proliferation+by+Regulating+Opioid+Growth+Factor+Receptor+%28OGFr%29&rft.jtitle=Molecular+%26+cellular+proteomics&rft.au=Wu%2C+Ying&rft.au=Xiong+Qian&rft.au=Li+Siting&rft.au=Yang%2C+Xue&rft.date=2018-01-01&rft.pub=American+Society+for+Biochemistry+and+Molecular+Biology&rft.issn=1535-9476&rft.eissn=1535-9484&rft.volume=17&rft.issue=1&rft.spage=146&rft.epage=159&rft_id=info:doi/10.1074%2Fmcp.RA117.000277&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1535-9476&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1535-9476&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1535-9476&client=summon |