Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb

• Published in: Applied microbiology and biotechnology Vol. 106; no. 4; pp. 1615 - 1631
• Main Authors: Yang, Lei, Wan, Yue, Li, Wenwen, Liu, Chen, Li, Hui-fang, Dong, Zhiling, Zhu, Ke, Jiang, Shu, Shang, Erxin, Qian, Dawei, Duan, Jinao
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2022; Springer; Springer Nature B.V
• Subjects: 25-hydroxycholecalciferol; Acids; Animals; Applied Microbial and Cell Physiology; Biomedical and Life Sciences; Biotechnology; Chenodeoxycholic acid; Cholic acid; Colon; Constipation; Correlation analysis; Defecation; Digestive system; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Feces; Feces - microbiology; Gastrointestinal Microbiome; Gastrointestinal tract; gastrointestinal transit; Gene sequencing; genes; Health aspects; Herbal medicine; High performance liquid chromatography; Intestinal microflora; intestinal microorganisms; Intestine; Laxatives; Laxatives - analysis; Laxatives - pharmacology; Laxatives - therapeutic use; Life Sciences; Linolenic acid; Liquid chromatography; lithocholic acid; Mass spectrometry; Mass spectroscopy; Metabolism; Metabolites; metabolome; Metabolomics; metagenomics; Microbial Genetics and Genomics; Microbiology; Microbiota; Microbiota (Symbiotic organisms); Moisture content; mucus; Next-generation sequencing; Physiological aspects; Probiotics; prostaglandins; Quadrupoles; Rats; Rheum - chemistry; Rhubarb; RNA, Ribosomal, 16S - genetics; rRNA 16S; Testing; Transit time; Water content; China; Gut microbiota; Rhubarb; Metabolites; Constipation

Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this stu...