Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb

Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this stu...

Full description

Saved in:
Bibliographic Details
Published inApplied microbiology and biotechnology Vol. 106; no. 4; pp. 1615 - 1631
Main Authors Yang, Lei, Wan, Yue, Li, Wenwen, Liu, Chen, Li, Hui-fang, Dong, Zhiling, Zhu, Ke, Jiang, Shu, Shang, Erxin, Qian, Dawei, Duan, Jinao
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2022
Springer
Springer Nature B.V
Subjects
25-hydroxycholecalciferol
Acids
Animals
Applied Microbial and Cell Physiology
Biomedical and Life Sciences
Biotechnology
Chenodeoxycholic acid
Cholic acid
Colon
Constipation
Correlation analysis
Defecation
Digestive system
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Feces
Feces - microbiology
Gastrointestinal Microbiome
Gastrointestinal tract
gastrointestinal transit
Gene sequencing
genes
Health aspects
Herbal medicine
High performance liquid chromatography
Intestinal microflora
intestinal microorganisms
Intestine
Laxatives
Laxatives - analysis
Laxatives - pharmacology
Laxatives - therapeutic use
Life Sciences
Linolenic acid
Liquid chromatography
lithocholic acid
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
metabolome
Metabolomics
metagenomics
Microbial Genetics and Genomics
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Moisture content
mucus
Next-generation sequencing
Physiological aspects
Probiotics
prostaglandins
Quadrupoles
Rats
Rheum - chemistry
Rhubarb
RNA, Ribosomal, 16S - genetics
rRNA 16S
Testing
Transit time
Water content
China
Gut microbiota
Rhubarb
Metabolites
Constipation
Online AccessGet full text

Cover

Abstract Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus , Limosilalactobacillus , and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2α, and α-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines. Key points • Rhubarb could significantly improve gut microbiota disorder in constipation rats. • Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.
AbstractList Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus, Limosilalactobacillus, and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2α, and α-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.Key points• Rhubarb could significantly improve gut microbiota disorder in constipation rats.• Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus, Limosilalactobacillus, and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2α, and α-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.Key points• Rhubarb could significantly improve gut microbiota disorder in constipation rats.• Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.
Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus , Limosilalactobacillus , and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2α, and α-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines. Key points • Rhubarb could significantly improve gut microbiota disorder in constipation rats. • Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.
Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus, Limosilalactobacillus, and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2α, and α-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.Key points• Rhubarb could significantly improve gut microbiota disorder in constipation rats.• Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.
Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus, Limosilalactobacillus, and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2[alpha], and [alpha]-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.
Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough. Currently, growing evidence suggests that intestinal flora might be a potential target for the treatment of constipation. Thus, the aim of this study was to clarify the laxative effect of rhubarb via systematically analyzing the metagenome and metabolome of the gut microbiota. In this study, the laxative effects of rhubarb were investigated by loperamide-induced constipation in rats. The gut microbiota was determined by high-throughput sequencing of 16S rRNA gene. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used for fecal metabolomics analysis. The data showed that rhubarb could significantly shorten gastrointestinal transit time, increase fecal water content and defecation frequency, improve gastrointestinal hormone disruption, and protect the colon mucus layer. Analysis of 16S rRNA gene sequencing indicated that rhubarb could improve the disorder of intestinal microbiota in constipated rats. For example, beneficial bacteria such as Ligilactobacillus, Limosilalactobacillus, and Prevotellaceae UCG-001 were remarkably increased, and pathogens such as Escherichia-Shigella were significantly decreased after rhubarb treatment. Additionally, the fecal metabolic profiles of constipated rats were improved by rhubarb. After rhubarb treatment, metabolites such as chenodeoxycholic acid, cholic acid, prostaglandin F2[alpha], and [alpha]-linolenic acid were markedly increased in constipation rats; in contrast, the metabolites such as lithocholic acid, calcidiol, and 10-hydroxystearic acid were notably reduced in constipation rats. Moreover, correlation analysis indicated a close relationship between intestinal flora, fecal metabolites, and biochemical indices associated with constipation. In conclusion, the amelioration of rhubarb in constipation might modulate the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines. Key points * Rhubarb could significantly improve gut microbiota disorder in constipation rats. * Rhubarb could markedly modulate the fecal metabolite profile of constipated rats.
Audience Academic
Author Qian, Dawei
Wan, Yue
Shang, Erxin
Yang, Lei
Li, Wenwen
Liu, Chen
Dong, Zhiling
Li, Hui-fang
Zhu, Ke
Jiang, Shu
Duan, Jinao
Author_xml – sequence: 1
  givenname: Lei
  surname: Yang
  fullname: Yang, Lei
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 2
  givenname: Yue
  surname: Wan
  fullname: Wan, Yue
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 3
  givenname: Wenwen
  surname: Li
  fullname: Li, Wenwen
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 4
  givenname: Chen
  surname: Liu
  fullname: Liu, Chen
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 5
  givenname: Hui-fang
  surname: Li
  fullname: Li, Hui-fang
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 6
  givenname: Zhiling
  surname: Dong
  fullname: Dong, Zhiling
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 7
  givenname: Ke
  surname: Zhu
  fullname: Zhu, Ke
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 8
  givenname: Shu
  orcidid: 0000-0003-0562-3787
  surname: Jiang
  fullname: Jiang, Shu
  email: jiangshu2020@126.com
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 9
  givenname: Erxin
  surname: Shang
  fullname: Shang, Erxin
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 10
  givenname: Dawei
  surname: Qian
  fullname: Qian, Dawei
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
– sequence: 11
  givenname: Jinao
  surname: Duan
  fullname: Duan, Jinao
  email: dja@njutcm.edu.cn
  organization: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35129656$$D View this record in MEDLINE/PubMed
BookMark eNqNkk1r3DAQhkVJaTZp_0APRdBLL05HliXZxxD6BYFeUuhNyPZoo2BbW0ku6b_vbDchNJRQzUFCet5X0sycsKMlLsjYawFnAsC8zwC1khXUdSVEK2SlnrGNaGRdgRbNEduAMKoyqmuP2UnONwCibrV-wY6lEnWnld6w71cubbGEZcvDUjDTyk3cTzE57paRh5L5jMX1cQp55iVyvN3RKfJyjXxyt66En8jRexwIjZ6n67V3qX_Jnns3ZXx1N5-ybx8_XF18ri6_fvpycX5ZDaoRpaplB6r10ECroOulNkYqaJ3qB9d7IX03mg58jyBRNAbEaPxo0Gg5-EZ5lKfs3cF3l-KPlT5g55AHnCa3YFyzrbVRSkujm_9AKSRQbgl9-wi9iWui1OwpSaMFoR6orZvQhsXHktywN7XnuqMci060RJ39g6IYcQ4DldQH2v9L8Obu8rWfcbS7FGaXftn7qhHQHoAhxZwTejuEQoWICzmHyQqw-waxhwax1CD2T4PY_ZPrR9J79ydF8iDKBC9bTA_ZeEL1G_zwyY0
CitedBy_id crossref_primary_10_1016_j_jep_2023_117378
crossref_primary_10_3389_fphar_2022_910493
crossref_primary_10_1016_j_prmcm_2024_100528
crossref_primary_10_1166_jbt_2023_3249
crossref_primary_10_3390_antiox12071400
crossref_primary_10_1177_09731296241245179
crossref_primary_10_1039_D4FO00695J
crossref_primary_10_1097_MD_0000000000037744
crossref_primary_10_3389_fphar_2023_1189971
crossref_primary_10_1016_j_tox_2022_153278
crossref_primary_10_3390_ijms232314685
crossref_primary_10_1016_j_arabjc_2024_105920
crossref_primary_10_3390_foods13142220
crossref_primary_10_4239_wjd_v15_i3_530
crossref_primary_10_3390_molecules29102198
crossref_primary_10_1007_s00210_023_02786_x
crossref_primary_10_1016_j_jchromb_2024_124331
crossref_primary_10_1016_j_bioorg_2023_107090
crossref_primary_10_3390_metabo15020139
crossref_primary_10_1039_D3FO03259K
crossref_primary_10_1016_j_cbi_2022_110193
crossref_primary_10_1016_j_ultsonch_2024_106986
crossref_primary_10_3389_fcimb_2024_1362773
crossref_primary_10_5582_bst_2024_01036
crossref_primary_10_1007_s00253_022_12044_4
crossref_primary_10_3389_fphar_2024_1442297
crossref_primary_10_1186_s40168_023_01690_z
crossref_primary_10_3389_fphar_2023_1107494
crossref_primary_10_1016_j_foodchem_2022_133840
crossref_primary_10_1016_j_biopha_2023_114769
crossref_primary_10_1016_j_fitote_2024_105969
crossref_primary_10_1186_s12951_024_02506_4
crossref_primary_10_3390_metabo14040216
crossref_primary_10_1007_s00253_022_12197_2
crossref_primary_10_1016_j_prmcm_2022_100200
crossref_primary_10_3920_BM2022_0009
crossref_primary_10_1007_s00253_023_12763_2
Cites_doi 10.1016/j.cgh.2013.04.020
10.1039/np9840100409
10.1038/s41575-019-0222-y
10.1016/j.cmet.2016.05.005
10.1053/j.gastro.2012.10.029
10.1194/jlr.RA119000200
10.3390/nu13030788
10.1186/1741-7007-11-61
10.1111/j.1440-1746.2006.04333.x
10.3389/fphar.2020.606227
10.1093/nar/gkab382
10.1538/expanim.63.415
10.1021/ac300698c
10.1093/nar/gkx1089
10.1124/jpet.115.225763
10.3390/foods10010199
10.1126/science.284.5423.2184
10.1111/nmo.13077
10.1177/0148607109336599
10.3389/fcimb.2015.00084
10.1248/bpb.b12-00632
10.3945/an.116.014407
10.5056/jnm.2014.20.1.31
10.1016/j.mayocp.2019.01.031
10.1053/j.gastro.2015.10.005
10.1007/s00431-020-03809-y
10.1016/j.crohns.2013.03.013
10.1016/j.jep.2020.113096
10.1093/carcin/21.5.999
10.3920/BM2018.0050
10.1590/fst.71921
10.3390/ijms18122645
10.1002/jms.1777
10.1053/j.gastro.2019.12.034
10.1053/j.gastro.2016.02.031
10.1016/j.ejphar.2009.04.045
10.1186/1752-153X-7-170
10.1038/nature11552
10.1053/j.gastro.2020.09.038
10.1053/j.gastro.2019.03.045
10.1080/19490976.2015.1134082
10.1053/j.gastro.2010.07.052
10.1016/j.cgh.2017.06.039
10.1111/j.1574-6968.2010.01911.x
10.1002/ptr.5410
10.1053/j.gastro.2016.07.044
10.18632/aging.203095
10.1016/j.bpg.2009.05.001
10.1007/s10620-012-2197-1
10.1186/s13020-020-00370-6
10.3390/app8030363
10.1111/jcmm.15586
10.1039/d0fo00865f
10.1152/ajpgi.00574.2004
10.1016/j.clnu.2012.08.010
10.1016/j.jphs.2019.06.012
10.1155/2011/152137
10.1042/0264-6021:3490189
10.1016/j.jep.2013.12.055
10.14309/ctg.0000000000000229
10.1016/j.bpg.2010.12.010
10.4049/immunohorizons.1900086
10.1111/j.1476-5381.2009.00464.x
10.3389/fmed.2019.00019
10.1111/apt.15106
10.2169/internalmedicine.8878-17
10.7150/thno.43528
10.1016/j.chom.2018.05.004
10.1038/s41598-017-10663-w
10.1002/mnfr.201500899
10.1186/s13020-020-00352-8
10.1053/j.gastro.2013.01.047
10.1186/s13104-020-05307-8
10.3390/ijms151221875
10.1016/j.cell.2016.01.013
10.1177/1756284820968423
10.1080/19490976.2015.1127483
10.1016/j.clnu.2013.03.004
10.1172/JCI106644
10.1021/acs.analchem.7b04424
10.1038/s41579-020-0433-9
10.12688/f1000research.18039.1
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
COPYRIGHT 2022 Springer
Copyright Springer Nature B.V. Feb 2022
Copyright_xml – notice: The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
– notice: 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
– notice: COPYRIGHT 2022 Springer
– notice: Copyright Springer Nature B.V. Feb 2022
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7T7
7WY
7WZ
7X7
7XB
87Z
88A
88E
88I
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
8FL
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BEZIV
BHPHI
C1K
CCPQU
DWQXO
FR3
FRNLG
FYUFA
F~G
GHDGH
GNUQQ
HCIFZ
K60
K6~
K9.
L.-
LK8
M0C
M0S
M1P
M2P
M7N
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQBIZ
PQBZA
PQEST
PQGLB
PQQKQ
PQUKI
Q9U
7X8
7S9
L.6
DOI 10.1007/s00253-022-11813-5
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Industrial and Applied Microbiology Abstracts (Microbiology A)
ABI/INFORM Collection
ABI/INFORM Global (PDF only)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
ABI/INFORM Global (Alumni Edition)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ABI/INFORM Collection (Alumni Edition)
ProQuest Central (Alumni Edition)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Business Premium Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Business Premium Collection (Alumni)
Health Research Premium Collection
ABI/INFORM Global (Corporate)
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Business Collection (Alumni Edition)
ProQuest Business Collection
ProQuest Health & Medical Complete (Alumni)
ABI/INFORM Professional Advanced
ProQuest Biological Science Collection
ABI/INFORM Global
Health & Medical Collection (Alumni Edition)
Medical Database
Science Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Business
ProQuest One Business (Alumni)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Business Collection (Alumni Edition)
ProQuest Central Student
ProQuest Central Essentials
SciTech Premium Collection
ABI/INFORM Complete
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Business Premium Collection
ABI/INFORM Global
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest Business Collection
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ABI/INFORM Global (Corporate)
ProQuest One Business
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ABI/INFORM Professional Advanced
ProQuest Health & Medical Research Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
ABI/INFORM Complete (Alumni Edition)
ABI/INFORM Global (Alumni Edition)
ProQuest Central Basic
ProQuest Science Journals
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest One Business (Alumni)
ProQuest Central (Alumni)
Business Premium Collection (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic

ProQuest Business Collection (Alumni Edition)

AGRICOLA

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Biology
EISSN 1432-0614
EndPage 1631
ExternalDocumentID A695121918
35129656
10_1007_s00253_022_11813_5
Genre Journal Article
GeographicLocations China
GeographicLocations_xml – name: China
GrantInformation_xml – fundername: Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization
  grantid: ZDXM-1-10
– fundername: National Natural Science Foundation of China
  grantid: No.82074126
  funderid: http://dx.doi.org/10.13039/501100001809
– fundername: National Natural Science Foundation of China
  grantid: No.82074126
GroupedDBID ---
-4W
-58
-5G
-BR
-EM
-Y2
-~C
.4S
.86
.DC
.VR
06C
06D
0R~
0VY
199
1N0
203
23M
28-
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
36B
3SX
3V.
4.4
406
408
409
40D
40E
53G
5GY
5QI
5VS
67N
67Z
6J9
6NX
78A
7WY
7X7
88A
88E
88I
8AO
8CJ
8FE
8FH
8FI
8FJ
8FL
8TC
8UJ
95-
95.
95~
96X
A8Z
AAAVM
AABHQ
AAHBH
AAHNG
AAIAL
AAJKR
AAJSJ
AAKKN
AANXM
AANZL
AARHV
AARTL
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
ABAKF
ABBBX
ABBXA
ABDBF
ABDZT
ABECU
ABEEZ
ABFTV
ABHLI
ABHQN
ABJNI
ABJOX
ABKCH
ABKTR
ABMNI
ABMOR
ABMQK
ABNWP
ABPLI
ABQBU
ABQSL
ABSXP
ABTAH
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACACY
ACBXY
ACGFO
ACGFS
ACGOD
ACHSB
ACHXU
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACREN
ACUHS
ACULB
ACZOJ
ADBBV
ADHIR
ADIMF
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADYOE
ADYPR
ADZKW
AEBTG
AEFIE
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEUYN
AEVLU
AEXYK
AFBBN
AFEXP
AFFNX
AFGCZ
AFGXO
AFKRA
AFLOW
AFQWF
AFRAH
AFWTZ
AFYQB
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHMBA
AHSBF
AHYZX
AI.
AIAKS
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMTXH
AMXSW
AMYLF
AOCGG
ARCSS
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B-.
B0M
BA0
BBNVY
BBWZM
BDATZ
BENPR
BEZIV
BGNMA
BHPHI
BPHCQ
BVXVI
C24
C6C
CAG
CCPQU
COF
CS3
CSCUP
D1J
DDRTE
DL5
DNIVK
DPUIP
DWQXO
EAD
EAP
EBD
EBLON
EBO
EBS
EDH
EDO
EIOEI
EJD
EMB
EMK
EMOBN
EN4
EPAXT
EPL
ESBYG
ESX
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRNLG
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNUQQ
GNWQR
GQ6
GQ7
GQ8
GROUPED_ABI_INFORM_COMPLETE
GXS
H13
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I-F
I09
IAG
IAO
IEP
IHE
IHR
IJ-
IKXTQ
INH
INR
ISR
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
K60
K6~
KDC
KOV
KOW
KPH
LAS
LK8
LLZTM
M0C
M0L
M1P
M2P
M4Y
M7P
MA-
ML0
MM.
N2Q
NB0
NDZJH
NHB
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P0-
P19
P2P
PF0
PQBIZ
PQBZA
PQQKQ
PROAC
PSQYO
PT5
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
RNI
RNS
ROL
RPX
RRX
RSV
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBY
SCLPG
SCM
SDH
SDM
SHX
SISQX
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TH9
TSG
TSK
TSV
TUC
TUS
U2A
U9L
UG4
UKHRP
UOJIU
UTJUX
UZXMN
VC2
VFIZW
VH1
W23
W48
WH7
WJK
WK6
WK8
YLTOR
Z45
Z5O
Z7R
Z7S
Z7U
Z7V
Z7W
Z7X
Z7Y
Z7Z
Z82
Z83
Z84
Z85
Z86
Z87
Z88
Z8M
Z8N
Z8O
Z8P
Z8Q
Z8R
Z8S
Z8T
Z8V
Z8W
Z8Y
Z8Z
Z91
Z92
ZMTXR
ZOVNA
ZXP
ZY4
~02
~8M
~EX
~KM
AASML
AAYXX
ABDBE
ABFSG
ACSTC
ADHKG
AEZWR
AFHIU
AGQPQ
AHPBZ
AHWEU
AIXLP
AYFIA
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
AEIIB
PMFND
7QL
7T7
7XB
8FD
8FK
C1K
FR3
K9.
L.-
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
Q9U
7X8
7S9
L.6
ID FETCH-LOGICAL-c541t-239058f0408509b36773508a5bcabf13f9d790fbe03e14701d7fd7e763cf45fe3
IEDL.DBID U2A
ISSN 0175-7598
1432-0614
IngestDate Thu Jul 10 22:09:38 EDT 2025
Tue Aug 05 10:29:00 EDT 2025
Sat Aug 23 05:11:29 EDT 2025
Tue Jun 17 21:28:40 EDT 2025
Tue Jun 10 20:21:29 EDT 2025
Thu Apr 24 04:15:08 EDT 2025
Tue Jul 01 00:41:37 EDT 2025
Thu Apr 24 22:56:23 EDT 2025
Fri Feb 21 02:47:45 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Gut microbiota
Rhubarb
Metabolites
Constipation
Language English
License 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c541t-239058f0408509b36773508a5bcabf13f9d790fbe03e14701d7fd7e763cf45fe3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0003-0562-3787
PMID 35129656
PQID 2633338015
PQPubID 54065
PageCount 17
ParticipantIDs proquest_miscellaneous_2675563764
proquest_miscellaneous_2626230100
proquest_journals_2633338015
gale_infotracmisc_A695121918
gale_infotracacademiconefile_A695121918
pubmed_primary_35129656
crossref_citationtrail_10_1007_s00253_022_11813_5
crossref_primary_10_1007_s00253_022_11813_5
springer_journals_10_1007_s00253_022_11813_5
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20220200
2022-02-00
2022-Feb
20220201
PublicationDateYYYYMMDD 2022-02-01
PublicationDate_xml – month: 2
  year: 2022
  text: 20220200
PublicationDecade 2020
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
– name: Germany
– name: Heidelberg
PublicationTitle Applied microbiology and biotechnology
PublicationTitleAbbrev Appl Microbiol Biotechnol
PublicationTitleAlternate Appl Microbiol Biotechnol
PublicationYear 2022
Publisher Springer Berlin Heidelberg
Springer
Springer Nature B.V
Publisher_xml – name: Springer Berlin Heidelberg
– name: Springer
– name: Springer Nature B.V
References Kaakoush (CR23) 2015; 5
Guijas, Montenegro-Burke, Domingo-Almenara, Palermo, Warth, Hermann, Koellensperger, Huan, Uritboonthai, Aisporna, Wolan, Spilker, Benton, Siuzdak (CR16) 2018; 90
Horai, Arita, Kanaya, Nihei, Ikeda, Suwa, Ojima, Tanaka, Tanaka, Aoshima, Oda, Kakazu, Kusano, Tohge, Matsuda, Sawada, Hirai, Nakanishi, Ikeda, Akimoto, Maoka, Takahashi, Ara, Sakurai, Suzuki, Shibata, Neumann, Iida, Tanaka, Funatsu, Matsuura, Soga, Taguchi, Saito, Nishioka (CR19) 2010; 45
Lu, Ji, Luo, Lan, Han, Chen, Liu, Lin, Lu, Wu, Guo, Zou (CR32) 2020; 11
Shimizu, Kageyama, Ogura, Yamada, Shimazu (CR55) 2018; 57
Costantini, Molinari, Farinon, Merendino (CR11) 2017; 18
Kelly, Yen, Grinspan, Kahn, Atreja, Lewis, Moore, Rubin, Kim, Serra, Nersesova, Fredell, Hunsicker, McDonald, Knight, Allegretti, Pekow, Absah, Hsu, Vincent, Khanna, Tangen, Crawford, Mattar, Chen, Fischer, Arsenescu, Feuerstadt, Goldstein, Kerman, Ehrlich, Wu, Laine (CR25) 2021; 160
Lan, Wang, Chen, Cao, Yang (CR30) 2020; 11
Mearin, Lacy, Chang, Chey, Lembo, Simren, Spiller (CR35) 2016; 150
Warner, Warner, Hardesty, Song, King, Kang, Chen, Xie, Yuan, Prodhan, Ma, Zhang, Rouchka, Maddipati, Whitlock, Li, Wang, McClain, Kirpich (CR73) 2019; 60
Bekele, Koike, Kobayashi (CR2) 2010; 305
Shin, Camilleri, Vijayvargiya, Busciglio, Burton, Ryks, Rhoten, Lueke, Saenger, Girtman, Zinsmeister (CR56) 2013; 11
Vriesman, Koppen, Camilleri, Di Lorenzo, Benninga (CR69) 2020; 17
Tautenhahn, Patti, Rinehart, Siuzdak (CR62) 2012; 84
Wang, Ma, Xu, He, Peng, Xiao (CR72) 2013; 7
Peng, Wu, Yang, Li (CR47) 2014; 63
Morrison, Preston (CR37) 2016; 7
Obata, Pachnis (CR40) 2016; 151
Yamada, Kanda (CR80) 2019; 140
Riezzo, Chimienti, Orlando, D'Attoma, Clemente, Russo (CR53) 2019; 10
Vijayvargiya, Camilleri, Burton, Busciglio, Lueke, Donato (CR68) 2019; 49
Plissonneau, Capel, Chassaing, Dupuit, Maillard, Wawrzyniak, Combaret, Dutheil, Etienne, Mairesse, Chesneau, Barnich, Boisseau (CR49) 2021; 13
Ohkusa, Koido, Nishikawa, Sato (CR41) 2019; 6
Bhattarai, Williams, Battaglioli, Whitaker, Till, Grover, Linden, Akiba, Kandimalla, Zachos, Kaunitz, Sonnenburg, Fischbach, Farrugia, Kashyap (CR6) 2018; 23
Cirillo, Capasso (CR9) 2015; 29
Steiger, Phan, Sun, Huang, Hess, Lopes, Korzenik, Langer, Traverso (CR57) 2020; 11
Bharucha, Dorn, Lembo, Pressman (CR5) 2013; 144
Kozoni, Tsioulias, Shiff, Rigas (CR28) 2000; 21
He, Han, Huang, Yang, Hu, Chen, Dou, Ren, Lin (CR18) 2020; 24
Kon, Ikarashi, Nagoya, Takayama, Kusunoki, Ishii, Ueda, Ochiai, Machida, Sugita, Sugiyama (CR27) 2014; 152
Feighner, Tan, McKee, Palyha, Hreniuk, Pong, Austin, Figueroa, MacNeil, Cascieri, Nargund, Bakshi, Abramovitz, Stocco, Kargman, O'Neill, Van Der Ploeg, Evans, Patchett, Smith, Howard (CR15) 1999; 284
Rao, Wong, Camilleri, Odunsi-Shiyanbade, McKinzie, Ryks, Burton, Carlson, Lamsam, Singh, Zinsmeister (CR51) 2010; 139
Liu, Liu, Liu, Xue, Jiang, Lei (CR31) 2021
Wahlström, Sayin, Marschall, Bäckhed (CR70) 2016; 24
Pattanakitsakul, Chongviriyaphan, Pakakasama, Apiwattanakul (CR44) 2020; 13
Xu, Ting-Lou, Zhu, Chen, Yang (CR79) 2009; 615
Vijayvargiya, Busciglio, Burton, Donato, Lueke, Camilleri (CR67) 2018; 16
Wu, Wei, Cheng, Qian, Xu, Yang, Wang, Chen, Sun, Lu (CR77) 2020; 10
Kashyap, Marcobal, Ursell, Larauche, Duboc, Earle, Sonnenburg, Ferreyra, Higginbottom, Million, Tache, Pasricha, Knight, Farrugia, Sonnenburg (CR24) 2013; 144
Trivić, Niseteo, Jadrešin, Hojsak (CR66) 2021; 180
Hou, Lin, Lin, Tsai (CR20) 2015; 355
Triantafyllou, Chang, Pimentel (CR65) 2014; 20
Bharucha, Wald (CR3) 2019; 94
Pang, Chong, Zhou, de Lima Morais, Chang, Barrette, Gauthier, Jacques, Li, Xia (CR45) 2021; 49
Pearl, Masoodi, Eiden, Brümmer, Gullick, McKeever, Whittaker, Nitch-Smith, Brown, Shute, Mills, Calder, Trebble (CR46) 2014; 8
Tremaroli, Bäckhed (CR64) 2012; 489
Wrzosek, Miquel, Noordine, Bouet, Joncquel Chevalier-Curt, Robert, Philippe, Bridonneau, Cherbuy, Robbe-Masselot, Langella, Thomas (CR76) 2013; 11
Mangian, Tappenden (CR34) 2009; 33
Mekjian, Phillips, Hofmann (CR36) 1971; 50
Parthasarathy, Chen, Chen, Chia, O'Connor, Wolf, Gaskins, Bharucha (CR43) 2016; 150
Wishart, Feunang, Marcu, Guo, Liang, Vázquez-Fresno, Sajed, Johnson, Li, Karu, Sayeeda, Lo, Assempour, Berjanskii, Singhal, Arndt, Liang, Badran, Grant, Serra-Cayuela, Liu, Mandal, Neveu, Pon, Knox, Wilson, Manach, Scalbert (CR75) 2018; 46
Lai, Manley (CR29) 1984; 1
Mancabelli, Milani, Lugli, Turroni, Mangifesta, Viappiani, Ticinesi, Nouvenne, Meschi, van Sinderen, Ventura (CR33) 2017; 7
Neyrinck, Etxeberria, Taminiau, Daube, Van Hul, Everard, Cani, Bindels, Delzenne (CR39) 2017; 61
Ridlon, Harris, Bhowmik, Kang, Hylemon (CR52) 2016; 7
Sender, Fuchs, Milo (CR54) 2016; 164
Takahashi, Sugi, Nakano, Kobayakawa, Nakanishi, Tsuda, Hosono, Kaminogawa (CR60) 2020; 4
Bharucha, Lacy (CR4) 2020; 158
Andromanakos, Skandalakis, Troupis, Filippou (CR1) 2006; 21
Takayama, Tsutsumi, Ishizu, Okamura (CR61) 2012; 35
Yang, Liu, Li, Bai, Shan, Gao, Dong (CR81) 2021; 13
Suo, Zhao, Qian, Li, Liu, Xie, Li (CR59) 2014; 15
Collins, Hogan, Skelly, Baird, Winter (CR10) 2009; 158
Chandrasekharan, Saeedi, Alam, Houser, Srinivasan, Tansey, Jones, Nusrat, Neish (CR7) 2019; 157
Jayasimhan, Yap, Roest, Rajandram, Chin (CR22) 2013; 32
Waitzberg, Logullo, Bittencourt, Torrinhas, Shiroma, Paulino, Teixeira-da-Silva (CR71) 2013; 32
Fan, Pedersen (CR14) 2021; 19
Dimidi, Christodoulides, Scott, Whelan (CR12) 2017; 8
Xiang, Zuo, Guo, Dong (CR78) 2020; 15
Wei, Luo, Zhang, Liu, Gasser, Tang, Ouyang, Wei, Lu, Yang, Waaga-Gasser, Deng, Lin (CR74) 2021; 264
Mugie, Benninga, Di Lorenzo (CR38) 2011; 25
Tian, Zuo, Guo, Li, Hu, Zhao, Li, Li, Zhou, Zhou, Li (CR63) 2020; 13
Durkin, Childs, Calder (CR13) 2021; 10
Qian, Song, Yi, Li, Sun, Zhao, Huo (CR50) 2018; 8
CR21
Sun, Wu, He, Jia, Wang, Liu, Hui, Li, Wei, Van Wijk, Van Wijk, Tsim, Li, Wang (CR58) 2020; 15
Park, Lee, Hussain, Lee, Park (CR42) 2017; 29
Kim, Deepinder, Morales, Hwang, Weitsman, Chang, Gunsalus, Pimentel (CR26) 2012; 57
Pimentel, Lin, Enayati, van den Burg, Lee, Chen, Park, Kong, Conklin (CR48) 2006; 290
Zhang, Yu, Kang, Zhu (CR82) 2011; 2011
Halvorsen, Staff, Ligaarden, Prydz, Kolset (CR17) 2000; 349
Chatoor, Emmnauel (CR8) 2009; 23
C Yang (11813_CR81) 2021; 13
Q Zhang (11813_CR82) 2011; 2011
P Pattanakitsakul (11813_CR44) 2020; 13
Y Peng (11813_CR47) 2014; 63
C Cirillo (11813_CR9) 2015; 29
R Kon (11813_CR27) 2014; 152
V Tremaroli (11813_CR64) 2012; 489
D Collins (11813_CR10) 2009; 158
11813_CR21
HS Mekjian (11813_CR36) 1971; 50
Y Obata (11813_CR40) 2016; 151
J Lan (11813_CR30) 2020; 11
B Halvorsen (11813_CR17) 2000; 349
D Chatoor (11813_CR8) 2009; 23
Z Pang (11813_CR45) 2021; 49
DL Waitzberg (11813_CR71) 2013; 32
SM Mugie (11813_CR38) 2011; 25
T Ohkusa (11813_CR41) 2019; 6
C Steiger (11813_CR57) 2020; 11
DJ Morrison (11813_CR37) 2016; 7
AE Bharucha (11813_CR5) 2013; 144
S Jayasimhan (11813_CR22) 2013; 32
AE Bharucha (11813_CR4) 2020; 158
AM Neyrinck (11813_CR39) 2017; 61
AE Bharucha (11813_CR3) 2019; 94
Z Lu (11813_CR32) 2020; 11
Q He (11813_CR18) 2020; 24
SM Lai (11813_CR29) 1984; 1
L Wei (11813_CR74) 2021; 264
R Sender (11813_CR54) 2016; 164
L Costantini (11813_CR11) 2017; 18
DS Pearl (11813_CR46) 2014; 8
M Pimentel (11813_CR48) 2006; 290
L Mancabelli (11813_CR33) 2017; 7
G Riezzo (11813_CR53) 2019; 10
PC Kashyap (11813_CR24) 2013; 144
JM Ridlon (11813_CR52) 2016; 7
K Takahashi (11813_CR60) 2020; 4
CR Kelly (11813_CR25) 2021; 160
F Mearin (11813_CR35) 2016; 150
C Plissonneau (11813_CR49) 2021; 13
DS Wishart (11813_CR75) 2018; 46
B Chandrasekharan (11813_CR7) 2019; 157
MH Vriesman (11813_CR69) 2020; 17
J Wu (11813_CR77) 2020; 10
SD Feighner (11813_CR15) 1999; 284
A Wahlström (11813_CR70) 2016; 24
H Horai (11813_CR19) 2010; 45
Y Bhattarai (11813_CR6) 2018; 23
Y Fan (11813_CR14) 2021; 19
H Suo (11813_CR59) 2014; 15
AZ Bekele (11813_CR2) 2010; 305
DR Warner (11813_CR73) 2019; 60
Y Qian (11813_CR50) 2018; 8
A Shin (11813_CR56) 2013; 11
K Shimizu (11813_CR55) 2018; 57
G Parthasarathy (11813_CR43) 2016; 150
L Xu (11813_CR79) 2009; 615
V Kozoni (11813_CR28) 2000; 21
E Dimidi (11813_CR12) 2017; 8
G Kim (11813_CR26) 2012; 57
Z Wang (11813_CR72) 2013; 7
P Vijayvargiya (11813_CR68) 2019; 49
K Takayama (11813_CR61) 2012; 35
P Vijayvargiya (11813_CR67) 2018; 16
LA Durkin (11813_CR13) 2021; 10
AS Rao (11813_CR51) 2010; 139
R Tautenhahn (11813_CR62) 2012; 84
M Sun (11813_CR58) 2020; 15
S Yamada (11813_CR80) 2019; 140
H Xiang (11813_CR78) 2020; 15
I Trivić (11813_CR66) 2021; 180
C Guijas (11813_CR16) 2018; 90
L Wrzosek (11813_CR76) 2013; 11
YM Park (11813_CR42) 2017; 29
ML Hou (11813_CR20) 2015; 355
P Liu (11813_CR31) 2021
NO Kaakoush (11813_CR23) 2015; 5
Y Tian (11813_CR63) 2020; 13
HF Mangian (11813_CR34) 2009; 33
K Triantafyllou (11813_CR65) 2014; 20
N Andromanakos (11813_CR1) 2006; 21
References_xml – volume: 11
  start-page: 1270
  year: 2013
  end-page: 1275
  ident: CR56
  article-title: Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2013.04.020
– volume: 1
  start-page: 409
  year: 1984
  end-page: 441
  ident: CR29
  article-title: Prostaglandins, thromboxanes, leukotrienes, and related arachidonic acid metabolites
  publication-title: Nat Prod Rep
  doi: 10.1039/np9840100409
– volume: 17
  start-page: 21
  year: 2020
  end-page: 39
  ident: CR69
  article-title: Management of functional constipation in children and adults
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/s41575-019-0222-y
– volume: 24
  start-page: 41
  year: 2016
  end-page: 50
  ident: CR70
  article-title: Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2016.05.005
– volume: 144
  start-page: 211
  year: 2013
  end-page: 217
  ident: CR5
  article-title: American gastroenterological association medical position statement on constipation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.10.029
– volume: 60
  start-page: 2034
  year: 2019
  end-page: 2049
  ident: CR73
  article-title: Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury
  publication-title: J Lipid Res
  doi: 10.1194/jlr.RA119000200
– volume: 13
  start-page: 788
  year: 2021
  ident: CR49
  article-title: High-intensity interval training and α-linolenic acid supplementation improve DHA conversion and increase the abundance of gut mucosa-associated bacteria
  publication-title: Nutrients
  doi: 10.3390/nu13030788
– volume: 11
  start-page: 61
  year: 2013
  ident: CR76
  article-title: and influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
  publication-title: Bmc Biol
  doi: 10.1186/1741-7007-11-61
– volume: 21
  start-page: 638
  year: 2006
  end-page: 646
  ident: CR1
  article-title: Constipation of anorectal outlet obstruction: pathophysiology, evaluation and management
  publication-title: J Gastroenterol Hepatol
  doi: 10.1111/j.1440-1746.2006.04333.x
– volume: 11
  year: 2020
  ident: CR32
  article-title: Nanoparticle-mediated delivery of emodin via colonic irrigation attenuates renal injury in 5/6 nephrectomized rats
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.606227
– volume: 49
  start-page: W388
  year: 2021
  end-page: W396
  ident: CR45
  article-title: MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkab382
– volume: 63
  start-page: 415
  year: 2014
  end-page: 422
  ident: CR47
  article-title: Gut microbial diversity in rat model induced by rhubarb
  publication-title: Exp Anim
  doi: 10.1538/expanim.63.415
– volume: 84
  start-page: 5035
  year: 2012
  end-page: 5039
  ident: CR62
  article-title: XCMS Online: a web-based platform to process untargeted metabolomic data
  publication-title: Anal Chem
  doi: 10.1021/ac300698c
– volume: 46
  start-page: D608
  year: 2018
  end-page: D617
  ident: CR75
  article-title: HMDB 4.0: the human metabolome database for 2018
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx1089
– volume: 355
  start-page: 125
  year: 2015
  end-page: 134
  ident: CR20
  article-title: The drug-drug effects of rhein on the pharmacokinetics and pharmacodynamics of clozapine in rat brain extracellular fluid by in vivo microdialysis
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.115.225763
– volume: 10
  start-page: 199
  year: 2021
  ident: CR13
  article-title: Omega-3 polyunsaturated fatty acids and the intestinal epithelium-a review
  publication-title: Foods
  doi: 10.3390/foods10010199
– volume: 284
  start-page: 2184
  year: 1999
  end-page: 2188
  ident: CR15
  article-title: Receptor for motilin identified in the human gastrointestinal system
  publication-title: Science
  doi: 10.1126/science.284.5423.2184
– volume: 29
  year: 2017
  ident: CR42
  article-title: The effects and mechanism of action of methane on ileal motor function
  publication-title: Neurogastroenterol Motil
  doi: 10.1111/nmo.13077
– volume: 33
  start-page: 607
  year: 2009
  end-page: 617
  ident: CR34
  article-title: Butyrate increases GLUT2 mRNA abundance by initiating transcription in Caco2-BBe cells
  publication-title: JPEN J Parenter Enteral Nutr
  doi: 10.1177/0148607109336599
– volume: 5
  start-page: 84
  year: 2015
  ident: CR23
  article-title: Insights into the role of in the human host
  publication-title: Front Cell Infect Microbiol
  doi: 10.3389/fcimb.2015.00084
– volume: 35
  start-page: 2204
  year: 2012
  end-page: 2208
  ident: CR61
  article-title: The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b12-00632
– volume: 8
  start-page: 484
  year: 2017
  end-page: 494
  ident: CR12
  article-title: Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation
  publication-title: Adv Nutr
  doi: 10.3945/an.116.014407
– ident: CR21
– volume: 20
  start-page: 31
  year: 2014
  end-page: 40
  ident: CR65
  article-title: Methanogens, methane and gastrointestinal motility
  publication-title: J Neurogastroenterol
  doi: 10.5056/jnm.2014.20.1.31
– volume: 94
  start-page: 2340
  year: 2019
  end-page: 2357
  ident: CR3
  article-title: Chronic constipation
  publication-title: Mayo Clin Proc
  doi: 10.1016/j.mayocp.2019.01.031
– volume: 150
  start-page: 367
  year: 2016
  end-page: 379
  ident: CR43
  article-title: Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.10.005
– volume: 180
  start-page: 339
  year: 2021
  end-page: 351
  ident: CR66
  article-title: Use of probiotics in the treatment of functional abdominal pain in children-systematic review and meta-analysis
  publication-title: Eur J Pediatr
  doi: 10.1007/s00431-020-03809-y
– volume: 8
  start-page: 70
  year: 2014
  end-page: 79
  ident: CR46
  article-title: Altered colonic mucosal availability of n-3 and n-6 polyunsaturated fatty acids in ulcerative colitis and the relationship to disease activity
  publication-title: J Crohns Colitis
  doi: 10.1016/j.crohns.2013.03.013
– volume: 264
  year: 2021
  ident: CR74
  article-title: Topical therapy with rhubarb navel plasters in patients with chronic constipation: results from a prospective randomized multicenter study
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2020.113096
– volume: 21
  start-page: 999
  year: 2000
  end-page: 1005
  ident: CR28
  article-title: The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/21.5.999
– volume: 10
  start-page: 137
  year: 2019
  end-page: 147
  ident: CR53
  article-title: Effects of long-term administration of DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation
  publication-title: Benef Microbes
  doi: 10.3920/BM2018.0050
– year: 2021
  ident: CR31
  article-title: Effect of α-linolenic acid (ALA) on proliferation of probiotics and its adhesion to colonic epithelial cells
  publication-title: Food Sci Tech
  doi: 10.1590/fst.71921
– volume: 18
  start-page: 2645
  year: 2017
  ident: CR11
  article-title: Impact of omega-3 fatty acids on the gut microbiota
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18122645
– volume: 45
  start-page: 703
  year: 2010
  end-page: 714
  ident: CR19
  article-title: MassBank: a public repository for sharing mass spectral data for life sciences
  publication-title: J Mass Spectrom
  doi: 10.1002/jms.1777
– volume: 158
  start-page: 1232
  year: 2020
  end-page: 1249
  ident: CR4
  article-title: Mechanisms, evaluation, and management of chronic constipation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.12.034
– volume: 150
  start-page: 1393
  year: 2016
  end-page: 1407
  ident: CR35
  article-title: Bowel disorders
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.02.031
– volume: 615
  start-page: 171
  year: 2009
  end-page: 176
  ident: CR79
  article-title: Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2009.04.045
– volume: 7
  start-page: 170
  year: 2013
  ident: CR72
  article-title: Evaluation of the content variation of anthraquinone glycosides in rhubarb by UPLC-PDA
  publication-title: Chem Cent J
  doi: 10.1186/1752-153X-7-170
– volume: 489
  start-page: 242
  year: 2012
  end-page: 249
  ident: CR64
  article-title: Functional interactions between the gut microbiota and host metabolism
  publication-title: Nature
  doi: 10.1038/nature11552
– volume: 160
  start-page: 183
  year: 2021
  end-page: 192
  ident: CR25
  article-title: Fecal microbiota transplantation is highly effective in real-world practice: initial results from the FMT national registry
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2020.09.038
– volume: 157
  start-page: 179
  year: 2019
  end-page: 192
  ident: CR7
  article-title: Interactions between commensal bacteria and enteric neurons, via FPR1 induction of ROS, increase gastrointestinal motility in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.045
– volume: 7
  start-page: 189
  year: 2016
  end-page: 200
  ident: CR37
  article-title: Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2015.1134082
– volume: 139
  start-page: 1549
  year: 2010
  end-page: 1558
  ident: CR51
  article-title: Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.07.052
– volume: 16
  start-page: 522
  year: 2018
  end-page: 527
  ident: CR67
  article-title: Bile acid deficiency in a subgroup of patients with irritable bowel syndrome with constipation based on biomarkers in serum and fecal samples
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2017.06.039
– volume: 305
  start-page: 49
  year: 2010
  end-page: 57
  ident: CR2
  article-title: Genetic diversity and diet specificity of ruminal revealed by 16S rRNA gene-based analysis
  publication-title: FEMS Microbiol Lett
  doi: 10.1111/j.1574-6968.2010.01911.x
– volume: 29
  start-page: 1488
  year: 2015
  end-page: 1493
  ident: CR9
  article-title: Constipation and botanical medicines: an overview
  publication-title: Phytother Res
  doi: 10.1002/ptr.5410
– volume: 151
  start-page: 836
  year: 2016
  end-page: 844
  ident: CR40
  article-title: The effect of microbiota and the immune system on the development and organization of the enteric nervous system
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.07.044
– volume: 13
  start-page: 15366
  year: 2021
  end-page: 15383
  ident: CR81
  article-title: The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis
  publication-title: Aging
  doi: 10.18632/aging.203095
– volume: 23
  start-page: 517
  year: 2009
  end-page: 530
  ident: CR8
  article-title: Constipation and evacuation disorders
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1016/j.bpg.2009.05.001
– volume: 57
  start-page: 3213
  year: 2012
  end-page: 3218
  ident: CR26
  article-title: is the predominant methanogen in patients with constipation-predominant IBS and methane on breath
  publication-title: Digest Dis Sci
  doi: 10.1007/s10620-012-2197-1
– volume: 15
  start-page: 88
  year: 2020
  ident: CR78
  article-title: What we already know about rhubarb: a comprehensive review
  publication-title: Chin Med
  doi: 10.1186/s13020-020-00370-6
– volume: 8
  start-page: 363
  year: 2018
  ident: CR50
  article-title: Preventive effects of YS4 on constipation induced by activated carbon in mice
  publication-title: Appl Sci
  doi: 10.3390/app8030363
– volume: 24
  start-page: 9349
  year: 2020
  end-page: 9361
  ident: CR18
  article-title: Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.15586
– volume: 11
  start-page: 9216
  year: 2020
  end-page: 9225
  ident: CR30
  article-title: Effects of inulin and isomalto-oligosaccharide on diphenoxylate-induced constipation, gastrointestinal motility-related hormones, short-chain fatty acids, and the intestinal flora in rats
  publication-title: Food Funct
  doi: 10.1039/d0fo00865f
– volume: 290
  start-page: G1089
  year: 2006
  end-page: G1095
  ident: CR48
  article-title: Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00574.2004
– volume: 32
  start-page: 27
  year: 2013
  end-page: 33
  ident: CR71
  article-title: Effect of synbiotic in constipated adult women - a randomized, double-blind, placebo-controlled study of clinical response
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2012.08.010
– volume: 140
  start-page: 337
  year: 2019
  end-page: 344
  ident: CR80
  article-title: Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers
  publication-title: J Pharmacol Sci
  doi: 10.1016/j.jphs.2019.06.012
– volume: 2011
  year: 2011
  ident: CR82
  article-title: Effect of ω-3 fatty acid on gastrointestinal motility after abdominal operation in rats
  publication-title: Mediat Inflamm
  doi: 10.1155/2011/152137
– volume: 349
  start-page: 189
  year: 2000
  end-page: 193
  ident: CR17
  article-title: Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2
  publication-title: Biochem J
  doi: 10.1042/0264-6021:3490189
– volume: 152
  start-page: 190
  year: 2014
  end-page: 200
  ident: CR27
  article-title: Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2013.12.055
– volume: 11
  start-page: e229
  year: 2020
  ident: CR57
  article-title: Controlled delivery of bile acids to the colon
  publication-title: Clin Transl Gastroenterol
  doi: 10.14309/ctg.0000000000000229
– volume: 25
  start-page: 3
  year: 2011
  end-page: 18
  ident: CR38
  article-title: Epidemiology of constipation in children and adults: a systematic review
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1016/j.bpg.2010.12.010
– volume: 4
  start-page: 178
  year: 2020
  end-page: 190
  ident: CR60
  article-title: Regulation of gene expression through gut microbiota-dependent DNA methylation in colonic epithelial cells
  publication-title: Immunohorizons
  doi: 10.4049/immunohorizons.1900086
– volume: 158
  start-page: 1771
  year: 2009
  end-page: 1776
  ident: CR10
  article-title: Cyclic AMP-mediated chloride secretion is induced by prostaglandin F2alpha in human isolated colon
  publication-title: Brit J Pharmacol
  doi: 10.1111/j.1476-5381.2009.00464.x
– volume: 6
  start-page: 19
  year: 2019
  ident: CR41
  article-title: Gut microbiota and chronic constipation: a review and update
  publication-title: Front Med
  doi: 10.3389/fmed.2019.00019
– volume: 49
  start-page: 744
  year: 2019
  end-page: 758
  ident: CR68
  article-title: Bile and fat excretion are biomarkers of clinically significant diarrhoea and constipation in irritable bowel syndrome
  publication-title: Aliment Pharm Ther
  doi: 10.1111/apt.15106
– volume: 57
  start-page: 507
  year: 2018
  end-page: 510
  ident: CR55
  article-title: Effects of rhubarb on intestinal dysmotility in critically ill patients
  publication-title: Intern Med
  doi: 10.2169/internalmedicine.8878-17
– volume: 10
  start-page: 10665
  year: 2020
  end-page: 10679
  ident: CR77
  article-title: Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis
  publication-title: Theranostics
  doi: 10.7150/thno.43528
– volume: 23
  start-page: 775
  year: 2018
  end-page: 785
  ident: CR6
  article-title: Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.05.004
– volume: 7
  start-page: 9879
  year: 2017
  ident: CR33
  article-title: Unveiling the gut microbiota composition and functionality associated with constipation through metagenomic analyses
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-10663-w
– volume: 61
  start-page: 1500899
  year: 2017
  ident: CR39
  article-title: Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.201500899
– volume: 15
  start-page: 72
  year: 2020
  ident: CR58
  article-title: Integrated assessment of medicinal rhubarb by combination of delayed luminescence and HPLC fingerprint with emphasized on bioactivities based quality control
  publication-title: Chin Med
  doi: 10.1186/s13020-020-00352-8
– volume: 144
  start-page: 967
  year: 2013
  end-page: 977
  ident: CR24
  article-title: Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.01.047
– volume: 13
  start-page: 464
  year: 2020
  ident: CR44
  article-title: Effect of vitamin A on intestinal mucosal injury in pediatric patients receiving hematopoietic stem cell transplantation and chemotherapy: a quasai-randomized trial
  publication-title: BMC Res Notes
  doi: 10.1186/s13104-020-05307-8
– volume: 15
  start-page: 21875
  year: 2014
  end-page: 21895
  ident: CR59
  article-title: Therapeutic effect of activated carbon-induced constipation mice with Suo on treatment
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms151221875
– volume: 164
  start-page: 337
  year: 2016
  end-page: 340
  ident: CR54
  article-title: Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans
  publication-title: Cell
  doi: 10.1016/j.cell.2016.01.013
– volume: 13
  start-page: 320810009
  year: 2020
  ident: CR63
  article-title: Potential role of fecal microbiota in patients with constipation
  publication-title: Therap Adv Gastroenterol
  doi: 10.1177/1756284820968423
– volume: 7
  start-page: 22
  year: 2016
  end-page: 39
  ident: CR52
  article-title: Consequences of bile salt biotransformations by intestinal bacteria
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2015.1127483
– volume: 32
  start-page: 928
  year: 2013
  end-page: 934
  ident: CR22
  article-title: Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2013.03.004
– volume: 50
  start-page: 1569
  year: 1971
  end-page: 1577
  ident: CR36
  article-title: Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man
  publication-title: J Clin Invest
  doi: 10.1172/JCI106644
– volume: 90
  start-page: 3156
  year: 2018
  end-page: 3164
  ident: CR16
  article-title: METLIN: a technology platform for identifying knowns and unknowns
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.7b04424
– volume: 19
  start-page: 55
  year: 2021
  end-page: 71
  ident: CR14
  article-title: Gut microbiota in human metabolic health and disease
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-020-0433-9
– volume: 15
  start-page: 72
  year: 2020
  ident: 11813_CR58
  publication-title: Chin Med
  doi: 10.1186/s13020-020-00352-8
– volume: 152
  start-page: 190
  year: 2014
  ident: 11813_CR27
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2013.12.055
– volume: 25
  start-page: 3
  year: 2011
  ident: 11813_CR38
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1016/j.bpg.2010.12.010
– volume: 2011
  year: 2011
  ident: 11813_CR82
  publication-title: Mediat Inflamm
  doi: 10.1155/2011/152137
– volume: 140
  start-page: 337
  year: 2019
  ident: 11813_CR80
  publication-title: J Pharmacol Sci
  doi: 10.1016/j.jphs.2019.06.012
– volume: 60
  start-page: 2034
  year: 2019
  ident: 11813_CR73
  publication-title: J Lipid Res
  doi: 10.1194/jlr.RA119000200
– volume: 57
  start-page: 507
  year: 2018
  ident: 11813_CR55
  publication-title: Intern Med
  doi: 10.2169/internalmedicine.8878-17
– volume: 24
  start-page: 41
  year: 2016
  ident: 11813_CR70
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2016.05.005
– volume: 10
  start-page: 137
  year: 2019
  ident: 11813_CR53
  publication-title: Benef Microbes
  doi: 10.3920/BM2018.0050
– volume: 4
  start-page: 178
  year: 2020
  ident: 11813_CR60
  publication-title: Immunohorizons
  doi: 10.4049/immunohorizons.1900086
– volume: 50
  start-page: 1569
  year: 1971
  ident: 11813_CR36
  publication-title: J Clin Invest
  doi: 10.1172/JCI106644
– volume: 290
  start-page: G1089
  year: 2006
  ident: 11813_CR48
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00574.2004
– volume: 1
  start-page: 409
  year: 1984
  ident: 11813_CR29
  publication-title: Nat Prod Rep
  doi: 10.1039/np9840100409
– volume: 7
  start-page: 189
  year: 2016
  ident: 11813_CR37
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2015.1134082
– volume: 13
  start-page: 464
  year: 2020
  ident: 11813_CR44
  publication-title: BMC Res Notes
  doi: 10.1186/s13104-020-05307-8
– volume: 158
  start-page: 1771
  year: 2009
  ident: 11813_CR10
  publication-title: Brit J Pharmacol
  doi: 10.1111/j.1476-5381.2009.00464.x
– volume: 284
  start-page: 2184
  year: 1999
  ident: 11813_CR15
  publication-title: Science
  doi: 10.1126/science.284.5423.2184
– volume: 49
  start-page: 744
  year: 2019
  ident: 11813_CR68
  publication-title: Aliment Pharm Ther
  doi: 10.1111/apt.15106
– volume: 305
  start-page: 49
  year: 2010
  ident: 11813_CR2
  publication-title: FEMS Microbiol Lett
  doi: 10.1111/j.1574-6968.2010.01911.x
– volume: 49
  start-page: W388
  year: 2021
  ident: 11813_CR45
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkab382
– volume: 158
  start-page: 1232
  year: 2020
  ident: 11813_CR4
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.12.034
– volume: 21
  start-page: 999
  year: 2000
  ident: 11813_CR28
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/21.5.999
– volume: 46
  start-page: D608
  year: 2018
  ident: 11813_CR75
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx1089
– volume: 7
  start-page: 170
  year: 2013
  ident: 11813_CR72
  publication-title: Chem Cent J
  doi: 10.1186/1752-153X-7-170
– volume: 13
  start-page: 788
  year: 2021
  ident: 11813_CR49
  publication-title: Nutrients
  doi: 10.3390/nu13030788
– volume: 10
  start-page: 199
  year: 2021
  ident: 11813_CR13
  publication-title: Foods
  doi: 10.3390/foods10010199
– volume: 84
  start-page: 5035
  year: 2012
  ident: 11813_CR62
  publication-title: Anal Chem
  doi: 10.1021/ac300698c
– volume: 20
  start-page: 31
  year: 2014
  ident: 11813_CR65
  publication-title: J Neurogastroenterol
  doi: 10.5056/jnm.2014.20.1.31
– volume: 180
  start-page: 339
  year: 2021
  ident: 11813_CR66
  publication-title: Eur J Pediatr
  doi: 10.1007/s00431-020-03809-y
– volume: 90
  start-page: 3156
  year: 2018
  ident: 11813_CR16
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.7b04424
– volume: 489
  start-page: 242
  year: 2012
  ident: 11813_CR64
  publication-title: Nature
  doi: 10.1038/nature11552
– volume: 151
  start-page: 836
  year: 2016
  ident: 11813_CR40
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.07.044
– volume: 355
  start-page: 125
  year: 2015
  ident: 11813_CR20
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.115.225763
– volume: 33
  start-page: 607
  year: 2009
  ident: 11813_CR34
  publication-title: JPEN J Parenter Enteral Nutr
  doi: 10.1177/0148607109336599
– volume: 63
  start-page: 415
  year: 2014
  ident: 11813_CR47
  publication-title: Exp Anim
  doi: 10.1538/expanim.63.415
– volume: 615
  start-page: 171
  year: 2009
  ident: 11813_CR79
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2009.04.045
– volume: 15
  start-page: 88
  year: 2020
  ident: 11813_CR78
  publication-title: Chin Med
  doi: 10.1186/s13020-020-00370-6
– volume: 13
  start-page: 320810009
  year: 2020
  ident: 11813_CR63
  publication-title: Therap Adv Gastroenterol
  doi: 10.1177/1756284820968423
– volume: 18
  start-page: 2645
  year: 2017
  ident: 11813_CR11
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18122645
– volume: 16
  start-page: 522
  year: 2018
  ident: 11813_CR67
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2017.06.039
– volume: 32
  start-page: 27
  year: 2013
  ident: 11813_CR71
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2012.08.010
– volume: 11
  start-page: 1270
  year: 2013
  ident: 11813_CR56
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2013.04.020
– volume: 35
  start-page: 2204
  year: 2012
  ident: 11813_CR61
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b12-00632
– volume: 45
  start-page: 703
  year: 2010
  ident: 11813_CR19
  publication-title: J Mass Spectrom
  doi: 10.1002/jms.1777
– volume: 61
  start-page: 1500899
  year: 2017
  ident: 11813_CR39
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.201500899
– volume: 32
  start-page: 928
  year: 2013
  ident: 11813_CR22
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2013.03.004
– volume: 150
  start-page: 367
  year: 2016
  ident: 11813_CR43
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.10.005
– volume: 7
  start-page: 22
  year: 2016
  ident: 11813_CR52
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2015.1127483
– volume: 15
  start-page: 21875
  year: 2014
  ident: 11813_CR59
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms151221875
– volume: 94
  start-page: 2340
  year: 2019
  ident: 11813_CR3
  publication-title: Mayo Clin Proc
  doi: 10.1016/j.mayocp.2019.01.031
– volume: 264
  year: 2021
  ident: 11813_CR74
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2020.113096
– volume: 23
  start-page: 775
  year: 2018
  ident: 11813_CR6
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2018.05.004
– volume: 11
  year: 2020
  ident: 11813_CR32
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.606227
– volume: 144
  start-page: 967
  year: 2013
  ident: 11813_CR24
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.01.047
– ident: 11813_CR21
  doi: 10.12688/f1000research.18039.1
– volume: 164
  start-page: 337
  year: 2016
  ident: 11813_CR54
  publication-title: Cell
  doi: 10.1016/j.cell.2016.01.013
– volume: 19
  start-page: 55
  year: 2021
  ident: 11813_CR14
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-020-0433-9
– volume: 24
  start-page: 9349
  year: 2020
  ident: 11813_CR18
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.15586
– volume: 157
  start-page: 179
  year: 2019
  ident: 11813_CR7
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.045
– volume: 11
  start-page: e229
  year: 2020
  ident: 11813_CR57
  publication-title: Clin Transl Gastroenterol
  doi: 10.14309/ctg.0000000000000229
– volume: 21
  start-page: 638
  year: 2006
  ident: 11813_CR1
  publication-title: J Gastroenterol Hepatol
  doi: 10.1111/j.1440-1746.2006.04333.x
– volume: 5
  start-page: 84
  year: 2015
  ident: 11813_CR23
  publication-title: Front Cell Infect Microbiol
  doi: 10.3389/fcimb.2015.00084
– year: 2021
  ident: 11813_CR31
  publication-title: Food Sci Tech
  doi: 10.1590/fst.71921
– volume: 7
  start-page: 9879
  year: 2017
  ident: 11813_CR33
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-10663-w
– volume: 139
  start-page: 1549
  year: 2010
  ident: 11813_CR51
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.07.052
– volume: 10
  start-page: 10665
  year: 2020
  ident: 11813_CR77
  publication-title: Theranostics
  doi: 10.7150/thno.43528
– volume: 150
  start-page: 1393
  year: 2016
  ident: 11813_CR35
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.02.031
– volume: 11
  start-page: 61
  year: 2013
  ident: 11813_CR76
  publication-title: Bmc Biol
  doi: 10.1186/1741-7007-11-61
– volume: 13
  start-page: 15366
  year: 2021
  ident: 11813_CR81
  publication-title: Aging
  doi: 10.18632/aging.203095
– volume: 349
  start-page: 189
  year: 2000
  ident: 11813_CR17
  publication-title: Biochem J
  doi: 10.1042/0264-6021:3490189
– volume: 17
  start-page: 21
  year: 2020
  ident: 11813_CR69
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/s41575-019-0222-y
– volume: 8
  start-page: 484
  year: 2017
  ident: 11813_CR12
  publication-title: Adv Nutr
  doi: 10.3945/an.116.014407
– volume: 29
  start-page: 1488
  year: 2015
  ident: 11813_CR9
  publication-title: Phytother Res
  doi: 10.1002/ptr.5410
– volume: 144
  start-page: 211
  year: 2013
  ident: 11813_CR5
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.10.029
– volume: 8
  start-page: 70
  year: 2014
  ident: 11813_CR46
  publication-title: J Crohns Colitis
  doi: 10.1016/j.crohns.2013.03.013
– volume: 160
  start-page: 183
  year: 2021
  ident: 11813_CR25
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2020.09.038
– volume: 23
  start-page: 517
  year: 2009
  ident: 11813_CR8
  publication-title: Best Pract Res Clin Gastroenterol
  doi: 10.1016/j.bpg.2009.05.001
– volume: 57
  start-page: 3213
  year: 2012
  ident: 11813_CR26
  publication-title: Digest Dis Sci
  doi: 10.1007/s10620-012-2197-1
– volume: 6
  start-page: 19
  year: 2019
  ident: 11813_CR41
  publication-title: Front Med
  doi: 10.3389/fmed.2019.00019
– volume: 8
  start-page: 363
  year: 2018
  ident: 11813_CR50
  publication-title: Appl Sci
  doi: 10.3390/app8030363
– volume: 29
  year: 2017
  ident: 11813_CR42
  publication-title: Neurogastroenterol Motil
  doi: 10.1111/nmo.13077
– volume: 11
  start-page: 9216
  year: 2020
  ident: 11813_CR30
  publication-title: Food Funct
  doi: 10.1039/d0fo00865f
SSID ssj0012866
Score 2.5420518
Snippet Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear enough....
SourceID proquest
gale
pubmed
crossref
springer
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1615
SubjectTerms 25-hydroxycholecalciferol
Acids
Animals
Applied Microbial and Cell Physiology
Biomedical and Life Sciences
Biotechnology
Chenodeoxycholic acid
Cholic acid
Colon
Constipation
Correlation analysis
Defecation
Digestive system
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Feces
Feces - microbiology
Gastrointestinal Microbiome
Gastrointestinal tract
gastrointestinal transit
Gene sequencing
genes
Health aspects
Herbal medicine
High performance liquid chromatography
Intestinal microflora
intestinal microorganisms
Intestine
Laxatives
Laxatives - analysis
Laxatives - pharmacology
Laxatives - therapeutic use
Life Sciences
Linolenic acid
Liquid chromatography
lithocholic acid
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
metabolome
Metabolomics
metagenomics
Microbial Genetics and Genomics
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Moisture content
mucus
Next-generation sequencing
Physiological aspects
Probiotics
prostaglandins
Quadrupoles
Rats
Rheum - chemistry
Rhubarb
RNA, Ribosomal, 16S - genetics
rRNA 16S
Testing
Transit time
Water content
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Ni9QwFA-6IuhBdP2qrhJB8KDBpPlqT7KIyyLoaRfmVpo0wYXZdp3pgP73vpdmujsLTnspJCkvyftK8vJ7hLzXQQpvVQ2CVBumqmhYFVXJjOkqby13IeF0__hpTs_V94Ve5A23dQ6r3OrEpKi7weMe-efSSHhAn-ovV78ZZo3C09WcQuMuuYfQZRjSZRfzggtU73RWCSaSWV1X-dJMujqHxh5PMEuGVy8l0zuG6bZ6vmGfbh2YJjt08pg8yg4kPZ5m_Am5E_pDcn9KKfn3kDy8ATD4lCzOUqA3fFPEhQBxxrYR1ugtbfuOXoxrehlGYITlxfqSjgMNKSYvUPAL6bL9k2DBaQ76oEOkq18b167cM3J-8u3s6ynLuRSY10qMrJQ111XkCGjGayeNtRJ8s1Y737ooZKw7W_PoApdBKMtFZ2NnA2gfH5WOQT4nB_3Qh5eEcu0q7gUPwlmluqptS1hzhLIWTpYyVgUR24FsfAYax3wXy2aGSE6D38DgN2nwG12Qj3ObqwlmY2_tDzg_Dcog_Nm3-SoB0IdoVs2xAb8RVLEAWo52aoLs-N3i7Qw3WXbXzTWnFeTdXIwtMR6tD8MG68ALupHzfXUsoq9ZowryYuKeuW8S_SxwpQvyactO1wT8v-Ov9tP7mjwokaNTUPkRORhXm_AGfKbRvU2C8Q_eCQzT
  priority: 102
  providerName: ProQuest
Title Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
URI https://link.springer.com/article/10.1007/s00253-022-11813-5
https://www.ncbi.nlm.nih.gov/pubmed/35129656
https://www.proquest.com/docview/2633338015
https://www.proquest.com/docview/2626230100
https://www.proquest.com/docview/2675563764
Volume 106
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9QwEB-8OwR9ED2_Vs8lguCDFvLZtI-7uuuheIjcwvpUmjTBg72u7HZB_3sn6Ye3hx7YPqSQSZsmmY8wM78AvFJOMKtljoyUp4nMfJpkXvIkTavMak2Nizjdn8_S04X8uFTLLils20e79y7JKKmHZLegnoPPkSchWVIk6gCOVNi74ype8MngO-BZ66FExZholWddqszf37Gnjq4L5Sta6ZqbNGqf-X2415mNZNLO8wO45epjuN0eJPnrGO5egRV8CMvzGN6NzySgQSATh7Yed-YlKeuKXDRbcukanP7VxfaSNGviYiSeI2gNklX5M4KBky7Ug6w92XzfmXJjHsFiPjt_d5p0JygkVknWJFzkVGWeBhgzmhuRai3QIiuVsaXxTPi80jn1xlHhmNSUVdpX2qHMsV4q78RjOKzXtXsKhCqTUcuoY0ZLWWVlyXGn4XjOjODCZyNg_UAWtoMXD6dcrIoBGDkOfoGDX8TBL9QI3gxtfrTgGjdSvw7zUwTOwzfbsksgwP4FDKtikqK1iAKYYV9O9iiRY-x-dT_DRcex24KnAi_U1_idl0N1aBmi0Gq33gUavFEiUnoTjQ6YazqVI3jSrp7h30SwrtCAHsHbfjn96cC_f_zZ_5E_hzs8rPAYWn4Ch81m516g5dSYMRzopR7D0WT6fjoP5Ydvn2ZYTmdnX76OIxv9BnMtDzk
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrRDlgKC8AgWMBOJAIxw_4uSAUIFWW9quENpKewtxYquVtknZzQr6p_iNjPNqtxJ7a_YSKXbkjOflnZlvAN5Iw4NMiRgFKQ59EdnQj6xgfhjmUaYU1abG6T4ahcNj8W0iJ2vwt6uFcWmVnU6sFXVeZu4_8g8s5HihPpWfzn_5rmuUi652LTQatjgwF7_xyDb_uP8V9_ctY3u74y9Dv-0q4GdSBJXP8JQvI0sdtBeNNQ-V4uilpFJnqbYBt3GuYmq1odwEQtEgVzZXBuUws0Jaw_G9t2BdcDzKDGD98-7o-48-bsGiJjqKRtlXMo7aMp26WM-5Fy5mynxX7Ml9uWQKrxuEKxbxWoi2tnx79-Fe67KSnYbHHsCaKTbhdtPE8mIT7l6BNHwIk3GdWo73xCFRoAJxc-0UOY2kRU5Oqzk5MxWy3vR0fkaqkpg6C9AQ9ETJNP1TA5GTNs2ElJbMThY6nelHcHwjdH4Mg6IszFMgVOqIZgE1gVZC5FGaMjzlGBYHmjNuIw-CjpBJ1kKbuw4b06QHZa6JnyDxk5r4ifTgfT_nvAH2WDn6ndufxEk9vjlL2-IFXJ_Dz0p2QvRUUfkHuJatpZEordny426Hk1ZbzJNL3vbgdf_YzXQZcIUpF24M_lAbU7pqjHJ4byoUHjxpuKf_Nu48O3TePdju2OlyAf__8Ger1_sK7gzHR4fJ4f7o4DlsMMfddUr7Fgyq2cK8QI-t0i9bMSHw86Yl8x-5nkoo
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIhAcEJTXQgEjgThAVDuO4-SAUEVZtRQqDq20tzRObFFpm5TdrKB_jV_HjPNotxJ7a3KJFDuyx_NyPPMNwBtlpSh0lKIgpXEQJS4OEheFQRyXSaE1N9bjdH8_iHePoq8TNVmDv30uDIVV9jrRK-qyLugf-VYYS7xQn6ot14VF_NgZfzr7FVAFKTpp7ctptCyyb89_4_Zt_nFvB9f6bRiOvxx-3g26CgNBoSLRBCHu-FXiOMF88dTIWGuJHkuuTJEbJ6RLS51yZyyXVkSai1K7UluUycJFylmJ370BN7GTIBnTk2Gzh2q_PSdF8xxolSZdwo5P2yNHg05Pw4DSPmWgloziVdNwyTZeOaz1NnB8H-51zivbbrntAazZagNuteUszzfg7iVww4cwOfRB5vjMCJMCVQn1dVPkOZZXJTtp5uzUNsiE05P5KWtqZn08oGXok7Jp_sdDkrMu4ITVjs1-Lkw-M4_g6Fqo_BjWq7qyT4FxZRJeCG6F0VFUJnke4n7HhqkwMpQuGYHoCZkVHcg51dqYZgM8syd-hsTPPPEzNYL3Q5-zFuJjZet3tD4ZyT9-uci7NAYcHyFpZdsx-qxoBgSOZXOpJcptsfy6X-Gs0xvz7ILLR_B6eE09KRausvWC2uCNepnzVW00Ib_pOBrBk5Z7hrlJ8vHQjR_Bh56dLgbw_4k_Wz3eV3Ab5TH7tnew_xzuhMTcPrZ9E9ab2cK-QNetMS-9jDA4vm6h_AfUTUz4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Targeting+intestinal+flora+and+its+metabolism+to+explore+the+laxative+effects+of+rhubarb&rft.jtitle=Applied+microbiology+and+biotechnology&rft.au=Yang%2C+Lei&rft.au=Wan%2C+Yue&rft.au=Li%2C+Wenwen&rft.au=Liu%2C+Chen&rft.date=2022-02-01&rft.pub=Springer&rft.issn=0175-7598&rft.volume=106&rft.issue=4&rft.spage=1615&rft_id=info:doi/10.1007%2Fs00253-022-11813-5&rft.externalDocID=A695121918
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0175-7598&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0175-7598&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0175-7598&client=summon