Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery

• Published in: Nature communications Vol. 15; no. 1; pp. 5689 - 17
• Main Authors: Li, Jinxin, Wu, Honghui, Yu, Zebin, Wang, Qiwei, Zeng, Xin, Qian, Wenchang, Lu, Siqi, Jiang, Lingli, Li, Jingyi, Zhu, Meng, Han, Yingli, Gao, Jianqing, Qian, Pengxu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/100; 631/61/54/989; 631/67/1059; 631/67/1990; Animals; Apoptosis; Apoptosis - drug effects; Biomimetics; Bone marrow; Bone Marrow - drug effects; Bone Marrow - metabolism; Bone Marrow - pathology; CD18 Antigens - metabolism; CD44 antigen; Cell adhesion; Cell adhesion molecules; Cell differentiation; Cell Differentiation - drug effects; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - metabolism; Cell membranes; Cell proliferation; Cell Proliferation - drug effects; Chemotherapy; Coated vesicles; Cytarabine; Cytarabine - pharmacology; Drug delivery; Drug Delivery Systems; Effectiveness; Hematopoietic stem cells; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Hemopoiesis; Humanities and Social Sciences; Humans; Hyaluronan Receptors - metabolism; Hyaluronic acid; Hyaluronic Acid - chemistry; Intercellular adhesion molecule 1; Leukemia; Leukemia - drug therapy; Leukemia - pathology; Liposomes; Malignancy; Membrane vesicles; Mice; multidisciplinary; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Osteoprogenitor cells; Progenitor cells; Science; Science (multidisciplinary); Stem cells; Vesicles

Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs to the bone marrow remains elusive. Here, we develop biomimetic vesicles by infusing hemat...