The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome

Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyt...

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Published in	Reviews in endocrine & metabolic disorders Vol. 16; no. 1; pp. 35 - 45
Main Authors	Zhang, Zhiguo, Zhou, Shanshan, Jiang, Xin, Wang, Yue-Hui, Li, Fengsheng, Wang, Yong-Gang, Zheng, Yang, Cai, Lu
Format	Journal Article
Language	English
Published	Boston Springer US 01.03.2015 Springer Nature B.V
Subjects	Diabetes Endocrinology Homeostasis - physiology Humans Insulin Resistance - physiology Internal Medicine Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 Medicine Medicine & Public Health Metabolic Syndrome - metabolism NF-E2-Related Factor 2 - metabolism Obesity - metabolism Reactive Oxygen Species - metabolism Signal Transduction - physiology Metabolic homeostasis Obesity Insulin resistance Reactive oxygen species Nrf2/Keap1
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Abstract	Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis.
AbstractList	Issue Title: Inflammation and ROS in Insulin Resistance Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis.Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis.
Author	Zhang, Zhiguo Li, Fengsheng Jiang, Xin Zheng, Yang Wang, Yue-Hui Cai, Lu Zhou, Shanshan Wang, Yong-Gang
Author_xml	– sequence: 1 givenname: Zhiguo surname: Zhang fullname: Zhang, Zhiguo organization: Departments of Cardiovascular Disorders, Gerontology & Radiation Oncology at the First Hospital, Jilin University, Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville – sequence: 2 givenname: Shanshan surname: Zhou fullname: Zhou, Shanshan organization: Departments of Cardiovascular Disorders, Gerontology & Radiation Oncology at the First Hospital, Jilin University, Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville – sequence: 3 givenname: Xin surname: Jiang fullname: Jiang, Xin organization: Departments of Cardiovascular Disorders, Gerontology & Radiation Oncology at the First Hospital, Jilin University, Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville – sequence: 4 givenname: Yue-Hui surname: Wang fullname: Wang, Yue-Hui organization: Departments of Cardiovascular Disorders, Gerontology & Radiation Oncology at the First Hospital, Jilin University – sequence: 5 givenname: Fengsheng surname: Li fullname: Li, Fengsheng organization: Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville, The Second Artillery General Hospital – sequence: 6 givenname: Yong-Gang surname: Wang fullname: Wang, Yong-Gang organization: Departments of Cardiovascular Disorders, Gerontology & Radiation Oncology at the First Hospital, Jilin University, Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville – sequence: 7 givenname: Yang surname: Zheng fullname: Zheng, Yang email: zhengyang@jlu.edu.cn organization: Departments of Cardiovascular Disorders, Gerontology & Radiation Oncology at the First Hospital, Jilin University – sequence: 8 givenname: Lu surname: Cai fullname: Cai, Lu email: l0cai001@louisville.edu organization: Kosair Children Hospital Research Institute, Department of Pediatrics, University of Louisville
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Cites_doi	10.1007/s10565-013-9239-0 10.1016/j.freeradbiomed.2011.10.453 10.1016/j.amepre.2011.10.026 10.2337/db11-1072 10.1074/jbc.274.15.10595 10.1038/35093050 10.1073/pnas.0902380106 10.1016/j.dsx.2013.10.004 10.1074/jbc.M109.093955 10.1530/JOE-13-0327 10.3390/ijms15046184 10.1038/nm.2049 10.1016/j.taap.2012.09.014 10.1128/MCB.00225-13 10.1089/ars.2010.3834 10.2337/db06-S002 10.1016/j.freeradbiomed.2012.02.022 10.1016/j.cmet.2013.04.005 10.1172/JCI37048 10.1073/pnas.0307301101 10.1210/me.2010-0224 10.2337/diabetes.50.2.404 10.1002/emmm.201302679 10.1016/j.ejphar.2009.08.022 10.1016/j.cmet.2010.11.004 10.1093/carcin/bgp100 10.1038/nature04634 10.2337/db11-1716 10.1016/j.taap.2013.04.023 10.1081/CEH-200031904 10.1016/j.bbalip.2009.12.006 10.1016/j.freeradbiomed.2012.09.025 10.3945/an.112.003103 10.1001/jama.297.8.842 10.1016/j.molcel.2007.03.016 10.1101/gad.201731.112 10.1007/s00125-010-2001-8 10.2337/db11-0112 10.1016/j.fct.2013.07.032 10.1016/j.taap.2010.03.016 10.1111/j.1365-2443.2010.01473.x 10.1016/j.biocel.2011.03.002 10.1016/j.jnutbio.2013.10.007 10.1128/MCB.00915-07 10.1073/pnas.0308096101 10.1128/MCB.24.5.1844-1854.2004 10.1007/s11684-013-0244-8 10.1242/bio.20121875 10.1074/jbc.M101053200 10.1093/toxsci/kfr183 10.1113/jphysiol.2013.258061 10.1111/bph.12057 10.1080/10409230591008189 10.1016/j.plefa.2005.04.004 10.1093/nar/gks409 10.1016/j.cmet.2009.08.009 10.1093/cvr/cvr010 10.3390/ijms14022684 10.1016/S0140-6736(11)60813-1 10.1124/jpet.109.162271 10.1016/j.freeradbiomed.2011.09.015 10.1089/ars.2013.5428 10.2337/db13-0909 10.1152/ajpgi.00322.2010 10.1074/jbc.M104115200 10.1089/jmf.2012.2559 10.2337/dc08-s246 10.1161/ATVBAHA.112.300345 10.2337/db12-0584 10.1038/ijo.2013.10 10.1007/s00125-011-2396-x 10.1056/NEJMoa0801891 10.1016/S0076-6879(02)48637-5 10.1016/j.taap.2008.11.007 10.1016/S0140-6736(08)60269-X 10.1161/CIR.0b013e31828124ad 10.1172/JCI37672 10.1074/jbc.M300931200 10.4239/wjd.v3.i5.94 10.1016/j.jprot.2010.03.018 10.1038/ijo.2011.279 10.3945/ajcn.2009.28449B 10.1016/S0140-6736(13)62365-X 10.1124/jpet.107.135822 10.1016/j.taap.2011.09.017 10.1016/j.molcel.2006.01.013 10.1073/pnas.0903485106 10.1016/j.freeradbiomed.2013.03.007 10.1016/j.advenzreg.2006.01.007
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References	Hoehn (CR50) 2009; 106 Yu (CR44) 2011; 54 Huang (CR65) 2010; 299 Bonnard (CR17) 2008; 118 Li (CR91) 2011; 90 Zhai, Ballinger, Messina (CR7) 2011; 25 Kaneto (CR23) 2001; 276 Straczkowski (CR67) 2013; 37 Collins (CR41) 2012; 32 Morino, Petersen, Shulman (CR21) 2006; 55 Gliemann (CR27) 2013; 591 Ristow (CR26) 2009; 106 D’Apolito (CR51) 2010; 120 Swinburn (CR2) 2011; 378 Pischon (CR4) 2008; 359 CR32 Tirosh (CR22) 1999; 274 Kim (CR57) 2013; 168 Bocci (CR28) 2014; 8 Meher (CR42) 2012; 52 de Champlain (CR88) 2004; 26 Chorley (CR81) 2012; 40 Barazzoni (CR83) 2012; 55 Loh (CR15) 2009; 10 Anderson (CR19) 2009; 119 Wakabayashi (CR12) 2004; 101 Veal, Day, Morgan (CR25) 2007; 26 Padmanabhan (CR9) 2006; 21 Kang (CR56) 2013; 17 Guo (CR6) 2014; 220 Kliewer, Mangelsdorf (CR38) 2010; 91 de Haan (CR14) 2011; 60 Xu (CR45) 2012; 61 Shin (CR80) 2007; 27 Jung, Choi (CR53) 2014; 15 Hou (CR78) 2012; 52 Virtue, Vidal-Puig (CR76) 2010; 1801 Chen (CR89) 2013; 14 McClung (CR35) 2004; 101 Vigouroux (CR75) 2011; 43 Kendig (CR34) 2011; 257 Merry (CR72) 2014; 20 Yagishita (CR86) 2014; 63 Lee (CR20) 2010; 12 Yoon (CR68) 2001; 413 Han (CR71) 2013; 29 Finkelstein (CR3) 2012; 42 Wu, Cui, Klaassen (CR63) 2011; 123 Bjelakovic (CR31) 2007; 297 Aleksunes (CR85) 2010; 333 Li (CR30) 2012; 36 Xue (CR43) 2013; 62 McMahon (CR11) 2003; 278 Zhang (CR54) 2013; 27 Choi (CR55) 2014; 25 Kay (CR64) 2011; 15 Lee (CR52) 2012; 53 Chartoumpekis (CR36) 2011; 60 Schneider, Chan (CR77) 2013; 4 More (CR59) 2013; 61C Zhang (CR39) 2012; 264 Otto, Lane (CR73) 2005; 40 Tanaka (CR16) 2008; 325 Ishii, Itoh, Yamamoto (CR13) 2002; 348 Huang (CR61) 2012; 1 Mahadev (CR24) 2004; 24 Go (CR5) 2013; 127 Houstis, Rosen, Lander (CR18) 2006; 440 Shin (CR46) 2009; 620 Gaikwad (CR33) 2001; 276 Pi (CR40) 2010; 285 Cheng (CR58) 2009; 15 Gao (CR47) 2013; 59 Rosen (CR74) 2005; 73 Song (CR84) 2009; 235 Gomez-Guzman (CR90) 2012; 52 Taguchi, Motohashi, Yamamoto (CR10) 2011; 16 Jin (CR70) 2013; 271 Kitteringham (CR62) 2010; 73 Zhang (CR69) 2010; 245 Lin (CR66) 2013; 17 Bahadoran, Mirmiran, Azizi (CR48) 2013; 16 He (CR49) 2012; 3 Renehan (CR1) 2008; 371 Watson (CR29) 2014; 383 Yates (CR60) 2009; 30 Maddux (CR8) 2001; 50 Chang (CR79) 2013; 5 Uruno (CR82) 2013; 33 Grossman (CR87) 2008; 31 Li, Zhang, Jia (CR37) 2013; 7 K Loh (9305_CR15) 2009; 10 MS Yates (9305_CR60) 2009; 30 AR Collins (9305_CR41) 2012; 32 TC Otto (9305_CR73) 2005; 40 UJ Jung (9305_CR53) 2014; 15 KL Hoehn (9305_CR50) 2009; 106 OH Kang (9305_CR56) 2013; 17 SH Jin (9305_CR70) 2013; 271 BH Lee (9305_CR52) 2012; 53 J Li (9305_CR91) 2011; 90 EA Finkelstein (9305_CR3) 2012; 42 S Shin (9305_CR46) 2009; 620 YK Zhang (9305_CR69) 2010; 245 A Gaikwad (9305_CR33) 2001; 276 Y Li (9305_CR30) 2012; 36 P Xue (9305_CR43) 2013; 62 VR More (9305_CR59) 2013; 61C KM Choi (9305_CR55) 2014; 25 Y Hou (9305_CR78) 2012; 52 JD Watson (9305_CR29) 2014; 383 H Kaneto (9305_CR23) 2001; 276 YC Chang (9305_CR79) 2013; 5 BA Swinburn (9305_CR2) 2011; 378 M Ristow (9305_CR26) 2009; 106 E Grossman (9305_CR87) 2008; 31 L Gliemann (9305_CR27) 2013; 591 R Barazzoni (9305_CR83) 2012; 55 K Morino (9305_CR21) 2006; 55 9305_CR32 K Mahadev (9305_CR24) 2004; 24 SA Kliewer (9305_CR38) 2010; 91 J Pi (9305_CR40) 2010; 285 HY Kay (9305_CR64) 2011; 15 KS Schneider (9305_CR77) 2013; 4 S Guo (9305_CR6) 2014; 220 MY Song (9305_CR84) 2009; 235 EA Veal (9305_CR25) 2007; 26 M McMahon (9305_CR11) 2003; 278 C Bonnard (9305_CR17) 2008; 118 LM Aleksunes (9305_CR85) 2010; 333 JP McClung (9305_CR35) 2004; 101 DV Chartoumpekis (9305_CR36) 2011; 60 TH Kim (9305_CR57) 2013; 168 TL Merry (9305_CR72) 2014; 20 L Zhai (9305_CR7) 2011; 25 NR Kitteringham (9305_CR62) 2010; 73 J Xu (9305_CR45) 2012; 61 J Huang (9305_CR65) 2010; 299 HJ He (9305_CR49) 2012; 3 W Zhang (9305_CR54) 2013; 27 Z Yu (9305_CR44) 2011; 54 Y Tanaka (9305_CR16) 2008; 325 H Li (9305_CR37) 2013; 7 KC Wu (9305_CR63) 2011; 123 C Vigouroux (9305_CR75) 2011; 43 AS Go (9305_CR5) 2013; 127 TM Chen (9305_CR89) 2013; 14 N Houstis (9305_CR18) 2006; 440 T Ishii (9305_CR13) 2002; 348 S Virtue (9305_CR76) 2010; 1801 S Shin (9305_CR80) 2007; 27 EL Kendig (9305_CR34) 2011; 257 J Champlain de (9305_CR88) 2004; 26 T Pischon (9305_CR4) 2008; 359 Z Lin (9305_CR66) 2013; 17 S Gao (9305_CR47) 2013; 59 Z Bahadoran (9305_CR48) 2013; 16 JC Yoon (9305_CR68) 2001; 413 HY Lee (9305_CR20) 2010; 12 M Straczkowski (9305_CR67) 2013; 37 EJ Anderson (9305_CR19) 2009; 119 AG Renehan (9305_CR1) 2008; 371 G Bjelakovic (9305_CR31) 2007; 297 ED Rosen (9305_CR74) 2005; 73 B Padmanabhan (9305_CR9) 2006; 21 N Wakabayashi (9305_CR12) 2004; 101 M D’Apolito (9305_CR51) 2010; 120 A Uruno (9305_CR82) 2013; 33 BN Chorley (9305_CR81) 2012; 40 BA Maddux (9305_CR8) 2001; 50 Z Cheng (9305_CR58) 2009; 15 K Taguchi (9305_CR10) 2011; 16 A Tirosh (9305_CR22) 1999; 274 Y Yagishita (9305_CR86) 2014; 63 S Han (9305_CR71) 2013; 29 YK Zhang (9305_CR39) 2012; 264 AK Meher (9305_CR42) 2012; 52 V Bocci (9305_CR28) 2014; 8 X Huang (9305_CR61) 2012; 1 JB Haan de (9305_CR14) 2011; 60 M Gomez-Guzman (9305_CR90) 2012; 52 22608371 - Am J Prev Med. 2012 Jun;42(6):563-70 23878368 - J Physiol. 2013 Oct 15;591(20):5047-59 12682069 - J Biol Chem. 2003 Jun 13;278(24):21592-600 11309386 - J Biol Chem. 2001 Jun 22;276(25):22559-64 23507082 - Free Radic Biol Med. 2013 Aug;61:85-94 23319124 - Adv Nutr. 2013 Jan 01;4(1):62-6 18280327 - Lancet. 2008 Feb 16;371(9612):569-78 24733068 - Int J Mol Sci. 2014 Apr 11;15(4):6184-223 17327526 - JAMA. 2007 Feb 28;297(8):842-57 19955654 - J Clin Invest. 2010 Jan;120(1):203-13 16507366 - Mol Cell. 2006 Mar 3;21(5):689-700 19005195 - N Engl J Med. 2008 Nov 13;359(20):2105-20 23358894 - Front Med. 2013 Mar;7(1):25-30 11885271 - Methods Enzymol. 2002;348:182-90 19071154 - Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67 21245055 - Cardiovasc Res. 2011 May 1;90(2):315-24 23631497 - J Med Food. 2013 May;16(5):375-82 19906798 - Am J Clin Nutr. 2010 Jan;91(1):254S-257S 21161163 - Diabetologia. 2011 Apr;54(4):922-34 11390407 - J Biol Chem. 2001 Aug 17;276(33):31099-104 19188683 - J Clin Invest. 2009 Mar;119(3):573-81 19808019 - Cell Metab. 2009 Oct;10(4):260-72 23022408 - Free Radic Biol Med. 2012 Dec 1;53(11):2008-16 21775727 - Toxicol Sci. 2011 Oct;123(2):590-600 23023374 - Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2839-46 15184668 - Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8852-7 18188455 - J Clin Invest. 2008 Feb;118(2):789-800 19698707 - Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44 22430302 - Int J Obes (Lond). 2012 Dec;36(12):1503-13 22936178 - Diabetes. 2012 Dec;61(12 ):3208-18 18281592 - J Pharmacol Exp Ther. 2008 May;325(2):655-64 21852674 - Diabetes. 2011 Oct;60(10):2465-73 22645638 - World J Diabetes. 2012 May 15;3(5):94-104 22001745 - Free Radic Biol Med. 2012 Jan 1;52(1):70-9 22138520 - Free Radic Biol Med. 2012 Jan 15;52(2):462-72 23828861 - EMBO Mol Med. 2013 Aug;5(8):1165-79 24252128 - Antioxid Redox Signal. 2014 May 10;20(14):2114-29 23358254 - Int J Mol Sci. 2013 Jan 28;14(2):2684-706 23017736 - Toxicol Appl Pharmacol. 2012 Nov 1;264(3):305-14 20399915 - J Proteomics. 2010 Jun 16;73(8):1612-31 19386581 - Carcinogenesis. 2009 Jun;30(6):1024-31 23431056 - Genes Dev. 2013 Feb 15;27(4):441-9 24445045 - J Nutr Biochem. 2014 Feb;25(2):201-7 15702613 - Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):593-601 15936931 - Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):31-4 23716596 - Mol Cell Biol. 2013 Aug;33(15):2996-3010 14966267 - Mol Cell Biol. 2004 Mar;24(5):1844-54 24661761 - Diabetes Metab Syndr. 2014 Jan-Mar;8(1):57-61 16126487 - Crit Rev Biochem Mol Biol. 2005 Jul-Aug;40(4):229-42 17130651 - Diabetes. 2006 Dec;55 Suppl 2:S9-S15 21251164 - Genes Cells. 2011 Feb;16(2):123-40 10187855 - J Biol Chem. 1999 Apr 9;274(15):10595-602 20089859 - J Biol Chem. 2010 Mar 19;285(12):9292-300 16887173 - Adv Enzyme Regul. 2006;46:113-40 17434122 - Mol Cell. 2007 Apr 13;26(1):1-14 20930048 - Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1211-21 22025774 - Diabetes. 2011 Nov;60(11):2683-4 19433800 - Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70 11557972 - Nature. 2001 Sep 13;413(6852):131-8 19805130 - Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92 24581668 - Lancet. 2014 Mar 1;383(9919):841-3 24281010 - J Endocrinol. 2014 Jan 08;220(2):T1-T23 21392585 - Int J Biochem Cell Biol. 2011 Jun;43(6):862-76 21872749 - Lancet. 2011 Aug 27;378(9793):804-14 23239837 - Circulation. 2013 Jan 1;127(1):e6-e245 23238296 - Diabetes. 2013 Mar;62(3):845-54 20056169 - Biochim Biophys Acta. 2010 Mar;1801(3):338-49 21239612 - Mol Endocrinol. 2011 Mar;25(3):492-502 16612386 - Nature. 2006 Apr 13;440(7086):944-8 23145499 - Br J Pharmacol. 2013 Apr;168(7):1647-61 22581777 - Nucleic Acids Res. 2012 Aug;40(15):7416-29 22370093 - Free Radic Biol Med. 2012 May 1;52(9):1708-15 21967773 - Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48 17709388 - Mol Cell Biol. 2007 Oct;27(20):7188-97 20086057 - J Pharmacol Exp Ther. 2010 Apr;333(1):140-51 23663741 - Cell Metab. 2013 May 7;17(5):779-89 11272154 - Diabetes. 2001 Feb;50(2):404-10 24186865 - Diabetes. 2014 Feb;63(2):605-18 23871787 - Food Chem Toxicol. 2013 Sep;59:739-47 19838201 - Nat Med. 2009 Nov;15(11):1307-11 24142602 - Eur Rev Med Pharmacol Sci. 2013 Oct;17(19):2578-86 23651738 - Toxicol Appl Pharmacol. 2013 Aug 15;271(1):95-105 21504366 - Antioxid Redox Signal. 2011 Oct 15;15(8):2135-46 20350562 - Toxicol Appl Pharmacol. 2010 Jun 15;245(3):326-34 23213463 - Biol Open. 2012 Aug 15;1(8):705-10 23463459 - Cell Biol Toxicol. 2013 Apr;29(2):75-84 21109199 - Cell Metab. 2010 Dec 1;12(6):668-74 14764894 - Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5 22159911 - Diabetologia. 2012 Mar;55(3):773-82 18227483 - Diabetes Care. 2008 Feb;31 Suppl 2:S185-9 23419601 - Int J Obes (Lond). 2013 Oct;37(10):1386-90
References_xml	– volume: 29 start-page: 75 issue: 2 year: 2013 end-page: 84 ident: CR71 article-title: How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale publication-title: Cell Biol Toxicol doi: 10.1007/s10565-013-9239-0 – volume: 118 start-page: 789 issue: 2 year: 2008 end-page: 800 ident: CR17 article-title: Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice publication-title: J Clin Invest – volume: 52 start-page: 462 issue: 2 year: 2012 end-page: 72 ident: CR78 article-title: Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein beta during adipogenesis publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2011.10.453 – volume: 42 start-page: 563 issue: 6 year: 2012 end-page: 70 ident: CR3 article-title: Obesity and severe obesity forecasts through 2030 publication-title: Am J Prev Med doi: 10.1016/j.amepre.2011.10.026 – volume: 60 start-page: 2683 issue: 11 year: 2011 end-page: 4 ident: CR14 article-title: Nrf2 activators as attractive therapeutics for diabetic nephropathy publication-title: Diabetes doi: 10.2337/db11-1072 – volume: 274 start-page: 10595 issue: 15 year: 1999 end-page: 602 ident: CR22 article-title: Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation publication-title: J Biol Chem doi: 10.1074/jbc.274.15.10595 – volume: 413 start-page: 131 issue: 6852 year: 2001 end-page: 8 ident: CR68 article-title: Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 publication-title: Nature doi: 10.1038/35093050 – volume: 106 start-page: 17787 issue: 42 year: 2009 end-page: 92 ident: CR50 article-title: Insulin resistance is a cellular antioxidant defense mechanism publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0902380106 – volume: 8 start-page: 57 issue: 1 year: 2014 end-page: 61 ident: CR28 article-title: An integrated medical treatment for type-2 diabetes publication-title: Diabetes Metab Syndr doi: 10.1016/j.dsx.2013.10.004 – volume: 285 start-page: 9292 issue: 12 year: 2010 end-page: 300 ident: CR40 article-title: Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity publication-title: J Biol Chem doi: 10.1074/jbc.M109.093955 – volume: 220 start-page: T1 issue: 2 year: 2014 end-page: 23 ident: CR6 article-title: Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms publication-title: J Endocrinol doi: 10.1530/JOE-13-0327 – volume: 17 start-page: 2578 issue: 19 year: 2013 end-page: 86 ident: CR56 article-title: Curcumin decreases oleic acid-induced lipid accumulation via AMPK phosphorylation in hepatocarcinoma cells publication-title: Eur Rev Med Pharmacol Sci – volume: 15 start-page: 6184 issue: 4 year: 2014 end-page: 223 ident: CR53 article-title: Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease publication-title: Int J Mol Sci doi: 10.3390/ijms15046184 – volume: 15 start-page: 1307 issue: 11 year: 2009 end-page: 11 ident: CR58 article-title: Foxo1 integrates insulin signaling with mitochondrial function in the liver publication-title: Nat Med doi: 10.1038/nm.2049 – volume: 264 start-page: 305 issue: 3 year: 2012 end-page: 14 ident: CR39 article-title: Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2012.09.014 – volume: 33 start-page: 2996 issue: 15 year: 2013 end-page: 3010 ident: CR82 article-title: The Keap1-Nrf2 system prevents onset of diabetes mellitus publication-title: Mol Cell Biol doi: 10.1128/MCB.00225-13 – volume: 15 start-page: 2135 issue: 8 year: 2011 end-page: 46 ident: CR64 article-title: Nrf2 inhibits LXRalpha-dependent hepatic lipogenesis by competing with FXR for acetylase binding publication-title: Antioxid Redox Signal doi: 10.1089/ars.2010.3834 – volume: 55 start-page: S9 issue: Supplement 2 year: 2006 end-page: 15 ident: CR21 article-title: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction publication-title: Diabetes doi: 10.2337/db06-S002 – volume: 52 start-page: 1708 issue: 9 year: 2012 end-page: 15 ident: CR42 article-title: Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2012.02.022 – volume: 17 start-page: 779 issue: 5 year: 2013 end-page: 89 ident: CR66 article-title: Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice publication-title: Cell Metab doi: 10.1016/j.cmet.2013.04.005 – volume: 119 start-page: 573 issue: 3 year: 2009 end-page: 81 ident: CR19 article-title: Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans publication-title: J Clin Invest doi: 10.1172/JCI37048 – volume: 101 start-page: 2040 issue: 7 year: 2004 end-page: 5 ident: CR12 article-title: Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0307301101 – volume: 25 start-page: 492 issue: 3 year: 2011 end-page: 502 ident: CR7 article-title: Role of reactive oxygen species in injury-induced insulin resistance publication-title: Mol Endocrinol doi: 10.1210/me.2010-0224 – volume: 50 start-page: 404 issue: 2 year: 2001 end-page: 10 ident: CR8 article-title: Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid publication-title: Diabetes doi: 10.2337/diabetes.50.2.404 – volume: 5 start-page: 1165 issue: 8 year: 2013 end-page: 79 ident: CR79 article-title: Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human publication-title: EMBO Mol Med doi: 10.1002/emmm.201302679 – volume: 620 start-page: 138 issue: 1–3 year: 2009 end-page: 44 ident: CR46 article-title: Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2009.08.022 – volume: 12 start-page: 668 issue: 6 year: 2010 end-page: 74 ident: CR20 article-title: Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance publication-title: Cell Metab doi: 10.1016/j.cmet.2010.11.004 – volume: 30 start-page: 1024 issue: 6 year: 2009 end-page: 31 ident: CR60 article-title: Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice publication-title: Carcinogenesis doi: 10.1093/carcin/bgp100 – volume: 440 start-page: 944 issue: 7086 year: 2006 end-page: 8 ident: CR18 article-title: Reactive oxygen species have a causal role in multiple forms of insulin resistance publication-title: Nature doi: 10.1038/nature04634 – volume: 61 start-page: 3208 issue: 12 year: 2012 end-page: 18 ident: CR45 article-title: Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice publication-title: Diabetes doi: 10.2337/db11-1716 – volume: 271 start-page: 95 issue: 1 year: 2013 end-page: 105 ident: CR70 article-title: Resveratrol inhibits LXRalpha-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2013.04.023 – volume: 26 start-page: 593 issue: 7–8 year: 2004 end-page: 601 ident: CR88 article-title: Oxidative stress in hypertension publication-title: Clin Exp Hypertens doi: 10.1081/CEH-200031904 – volume: 1801 start-page: 338 issue: 3 year: 2010 end-page: 49 ident: CR76 article-title: Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome–an allostatic perspective publication-title: Biochim Biophys Acta doi: 10.1016/j.bbalip.2009.12.006 – volume: 53 start-page: 2008 issue: 11 year: 2012 end-page: 16 ident: CR52 article-title: Ankaflavin: a natural novel PPARgamma agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2012.09.025 – volume: 4 start-page: 62 issue: 1 year: 2013 end-page: 6 ident: CR77 article-title: Emerging role of Nrf2 in adipocytes and adipose biology publication-title: Adv Nutr doi: 10.3945/an.112.003103 – volume: 297 start-page: 842 issue: 8 year: 2007 end-page: 57 ident: CR31 article-title: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention publication-title: J Am Med Assoc doi: 10.1001/jama.297.8.842 – volume: 26 start-page: 1 issue: 1 year: 2007 end-page: 14 ident: CR25 article-title: Hydrogen peroxide sensing and signaling publication-title: Mol Cell doi: 10.1016/j.molcel.2007.03.016 – ident: CR32 – volume: 27 start-page: 441 issue: 4 year: 2013 end-page: 9 ident: CR54 article-title: ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation publication-title: Genes Dev doi: 10.1101/gad.201731.112 – volume: 54 start-page: 922 issue: 4 year: 2011 end-page: 34 ident: CR44 article-title: Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice publication-title: Diabetologia doi: 10.1007/s00125-010-2001-8 – volume: 60 start-page: 2465 issue: 10 year: 2011 end-page: 73 ident: CR36 article-title: Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice publication-title: Diabetes doi: 10.2337/db11-0112 – volume: 59 start-page: 739 year: 2013 end-page: 47 ident: CR47 article-title: Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2013.07.032 – volume: 245 start-page: 326 issue: 3 year: 2010 end-page: 34 ident: CR69 article-title: Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2010.03.016 – volume: 16 start-page: 123 issue: 2 year: 2011 end-page: 40 ident: CR10 article-title: Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution publication-title: Genes Cells doi: 10.1111/j.1365-2443.2010.01473.x – volume: 43 start-page: 862 issue: 6 year: 2011 end-page: 76 ident: CR75 article-title: Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2011.03.002 – volume: 25 start-page: 201 issue: 2 year: 2014 end-page: 7 ident: CR55 article-title: Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2013.10.007 – volume: 27 start-page: 7188 issue: 20 year: 2007 end-page: 97 ident: CR80 article-title: NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis publication-title: Mol Cell Biol doi: 10.1128/MCB.00915-07 – volume: 101 start-page: 8852 issue: 24 year: 2004 end-page: 7 ident: CR35 article-title: Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0308096101 – volume: 24 start-page: 1844 issue: 5 year: 2004 end-page: 54 ident: CR24 article-title: The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction publication-title: Mol Cell Biol doi: 10.1128/MCB.24.5.1844-1854.2004 – volume: 7 start-page: 25 issue: 1 year: 2013 end-page: 30 ident: CR37 article-title: Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology publication-title: Front Med doi: 10.1007/s11684-013-0244-8 – volume: 1 start-page: 705 issue: 8 year: 2012 end-page: 10 ident: CR61 article-title: The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis publication-title: Biol Open doi: 10.1242/bio.20121875 – volume: 276 start-page: 22559 issue: 25 year: 2001 end-page: 64 ident: CR33 article-title: In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue publication-title: J Biol Chem doi: 10.1074/jbc.M101053200 – volume: 123 start-page: 590 issue: 2 year: 2011 end-page: 600 ident: CR63 article-title: Beneficial role of Nrf2 in regulating NADPH generation and consumption publication-title: Toxicol Sci doi: 10.1093/toxsci/kfr183 – volume: 591 start-page: 5047 issue: Pt 20 year: 2013 end-page: 59 ident: CR27 article-title: Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men publication-title: J Physiol doi: 10.1113/jphysiol.2013.258061 – volume: 168 start-page: 1647 issue: 7 year: 2013 end-page: 61 ident: CR57 article-title: An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK publication-title: Br J Pharmacol doi: 10.1111/bph.12057 – volume: 40 start-page: 229 issue: 4 year: 2005 end-page: 42 ident: CR73 article-title: Adipose development: from stem cell to adipocyte publication-title: Crit Rev Biochem Mol Biol doi: 10.1080/10409230591008189 – volume: 73 start-page: 31 issue: 1 year: 2005 end-page: 4 ident: CR74 article-title: The transcriptional basis of adipocyte development publication-title: Prostaglandins Leukot Essent Fatty Acids doi: 10.1016/j.plefa.2005.04.004 – volume: 40 start-page: 7416 issue: 15 year: 2012 end-page: 29 ident: CR81 article-title: Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha publication-title: Nucleic Acids Res doi: 10.1093/nar/gks409 – volume: 10 start-page: 260 issue: 4 year: 2009 end-page: 72 ident: CR15 article-title: Reactive oxygen species enhance insulin sensitivity publication-title: Cell Metab doi: 10.1016/j.cmet.2009.08.009 – volume: 90 start-page: 315 issue: 2 year: 2011 end-page: 24 ident: CR91 article-title: Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy publication-title: Cardiovasc Res doi: 10.1093/cvr/cvr010 – volume: 14 start-page: 2684 issue: 2 year: 2013 end-page: 706 ident: CR89 article-title: Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction publication-title: Int J Mol Sci doi: 10.3390/ijms14022684 – volume: 378 start-page: 804 issue: 9793 year: 2011 end-page: 14 ident: CR2 article-title: The global obesity pandemic: shaped by global drivers and local environments publication-title: Lancet doi: 10.1016/S0140-6736(11)60813-1 – volume: 333 start-page: 140 issue: 1 year: 2010 end-page: 51 ident: CR85 article-title: Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.109.162271 – volume: 52 start-page: 70 issue: 1 year: 2012 end-page: 9 ident: CR90 article-title: Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2011.09.015 – volume: 20 start-page: 2114 issue: 14 year: 2014 end-page: 29 ident: CR72 article-title: High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage publication-title: Antioxid Redox Signal doi: 10.1089/ars.2013.5428 – volume: 63 start-page: 605 issue: 2 year: 2014 end-page: 18 ident: CR86 article-title: Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice publication-title: Diabetes doi: 10.2337/db13-0909 – volume: 299 start-page: G1211 issue: 6 year: 2010 end-page: 21 ident: CR65 article-title: Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00322.2010 – volume: 276 start-page: 31099 issue: 33 year: 2001 end-page: 104 ident: CR23 article-title: Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function through the induction of oxidative stress publication-title: J Bio Chem doi: 10.1074/jbc.M104115200 – volume: 16 start-page: 375 issue: 5 year: 2013 end-page: 82 ident: CR48 article-title: Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications publication-title: J Med Food doi: 10.1089/jmf.2012.2559 – volume: 31 start-page: S185 issue: Suppl 2 year: 2008 end-page: 9 ident: CR87 article-title: Does increased oxidative stress cause hypertension? publication-title: Diabetes Care doi: 10.2337/dc08-s246 – volume: 32 start-page: 2839 issue: 12 year: 2012 end-page: 46 ident: CR41 article-title: Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.112.300345 – volume: 62 start-page: 845 issue: 3 year: 2013 end-page: 54 ident: CR43 article-title: Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome publication-title: Diabetes doi: 10.2337/db12-0584 – volume: 37 start-page: 1386 issue: 10 year: 2013 end-page: 90 ident: CR67 article-title: Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2013.10 – volume: 55 start-page: 773 issue: 3 year: 2012 end-page: 82 ident: CR83 article-title: Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-kappaB inhibitor (IkappaB)-nuclear factor-kappaB (NFkappaB) activation in rat muscle, in the absence of mitochondrial dysfunction publication-title: Diabetologia doi: 10.1007/s00125-011-2396-x – volume: 359 start-page: 2105 issue: 20 year: 2008 end-page: 20 ident: CR4 article-title: General and abdominal adiposity and risk of death in Europe publication-title: N Engl J Med doi: 10.1056/NEJMoa0801891 – volume: 348 start-page: 182 year: 2002 end-page: 90 ident: CR13 article-title: Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements publication-title: Methods Enzymol doi: 10.1016/S0076-6879(02)48637-5 – volume: 235 start-page: 57 issue: 1 year: 2009 end-page: 67 ident: CR84 article-title: Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2008.11.007 – volume: 371 start-page: 569 issue: 9612 year: 2008 end-page: 78 ident: CR1 article-title: Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies publication-title: Lancet doi: 10.1016/S0140-6736(08)60269-X – volume: 127 start-page: e6 issue: 1 year: 2013 end-page: 245 ident: CR5 article-title: Heart disease and stroke statistics–2013 update: a report from the American heart association publication-title: Circulation doi: 10.1161/CIR.0b013e31828124ad – volume: 120 start-page: 203 issue: 1 year: 2010 end-page: 13 ident: CR51 article-title: Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure publication-title: J Clin Invest doi: 10.1172/JCI37672 – volume: 278 start-page: 21592 issue: 24 year: 2003 end-page: 600 ident: CR11 article-title: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression publication-title: J Biol Chem doi: 10.1074/jbc.M300931200 – volume: 3 start-page: 94 issue: 5 year: 2012 end-page: 104 ident: CR49 article-title: Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice publication-title: World J Diabetes doi: 10.4239/wjd.v3.i5.94 – volume: 73 start-page: 1612 issue: 8 year: 2010 end-page: 31 ident: CR62 article-title: Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver publication-title: J Proteomics doi: 10.1016/j.jprot.2010.03.018 – volume: 36 start-page: 1503 issue: 12 year: 2012 end-page: 13 ident: CR30 article-title: Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2011.279 – volume: 91 start-page: 254S issue: 1 year: 2010 end-page: 7 ident: CR38 article-title: Fibroblast growth factor 21: from pharmacology to physiology publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.28449B – volume: 383 start-page: 841 issue: 9919 year: 2014 end-page: 3 ident: CR29 article-title: Type 2 diabetes as a redox disease publication-title: Lancet doi: 10.1016/S0140-6736(13)62365-X – volume: 325 start-page: 655 issue: 2 year: 2008 end-page: 64 ident: CR16 article-title: NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.107.135822 – volume: 257 start-page: 338 issue: 3 year: 2011 end-page: 48 ident: CR34 article-title: Lipid metabolism and body composition in Gclm(−/−) mice publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2011.09.017 – volume: 21 start-page: 689 issue: 5 year: 2006 end-page: 700 ident: CR9 article-title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer publication-title: Mol Cell doi: 10.1016/j.molcel.2006.01.013 – volume: 106 start-page: 8665 issue: 21 year: 2009 end-page: 70 ident: CR26 article-title: Antioxidants prevent health-promoting effects of physical exercise in humans publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0903485106 – volume: 61C start-page: 85 year: 2013 end-page: 94 ident: CR59 article-title: Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.03.007 – volume: 12 start-page: 668 issue: 6 year: 2010 ident: 9305_CR20 publication-title: Cell Metab doi: 10.1016/j.cmet.2010.11.004 – volume: 274 start-page: 10595 issue: 15 year: 1999 ident: 9305_CR22 publication-title: J Biol Chem doi: 10.1074/jbc.274.15.10595 – volume: 591 start-page: 5047 issue: Pt 20 year: 2013 ident: 9305_CR27 publication-title: J Physiol doi: 10.1113/jphysiol.2013.258061 – volume: 17 start-page: 779 issue: 5 year: 2013 ident: 9305_CR66 publication-title: Cell Metab doi: 10.1016/j.cmet.2013.04.005 – volume: 15 start-page: 6184 issue: 4 year: 2014 ident: 9305_CR53 publication-title: Int J Mol Sci doi: 10.3390/ijms15046184 – volume: 32 start-page: 2839 issue: 12 year: 2012 ident: 9305_CR41 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.112.300345 – volume: 120 start-page: 203 issue: 1 year: 2010 ident: 9305_CR51 publication-title: J Clin Invest doi: 10.1172/JCI37672 – volume: 413 start-page: 131 issue: 6852 year: 2001 ident: 9305_CR68 publication-title: Nature doi: 10.1038/35093050 – volume: 220 start-page: T1 issue: 2 year: 2014 ident: 9305_CR6 publication-title: J Endocrinol doi: 10.1530/JOE-13-0327 – volume: 33 start-page: 2996 issue: 15 year: 2013 ident: 9305_CR82 publication-title: Mol Cell Biol doi: 10.1128/MCB.00225-13 – volume: 16 start-page: 375 issue: 5 year: 2013 ident: 9305_CR48 publication-title: J Med Food doi: 10.1089/jmf.2012.2559 – volume: 168 start-page: 1647 issue: 7 year: 2013 ident: 9305_CR57 publication-title: Br J Pharmacol doi: 10.1111/bph.12057 – volume: 3 start-page: 94 issue: 5 year: 2012 ident: 9305_CR49 publication-title: World J Diabetes doi: 10.4239/wjd.v3.i5.94 – volume: 1 start-page: 705 issue: 8 year: 2012 ident: 9305_CR61 publication-title: Biol Open doi: 10.1242/bio.20121875 – volume: 60 start-page: 2465 issue: 10 year: 2011 ident: 9305_CR36 publication-title: Diabetes doi: 10.2337/db11-0112 – volume: 54 start-page: 922 issue: 4 year: 2011 ident: 9305_CR44 publication-title: Diabetologia doi: 10.1007/s00125-010-2001-8 – volume: 378 start-page: 804 issue: 9793 year: 2011 ident: 9305_CR2 publication-title: Lancet doi: 10.1016/S0140-6736(11)60813-1 – volume: 101 start-page: 8852 issue: 24 year: 2004 ident: 9305_CR35 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0308096101 – volume: 127 start-page: e6 issue: 1 year: 2013 ident: 9305_CR5 publication-title: Circulation doi: 10.1161/CIR.0b013e31828124ad – volume: 24 start-page: 1844 issue: 5 year: 2004 ident: 9305_CR24 publication-title: Mol Cell Biol doi: 10.1128/MCB.24.5.1844-1854.2004 – volume: 37 start-page: 1386 issue: 10 year: 2013 ident: 9305_CR67 publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2013.10 – volume: 15 start-page: 1307 issue: 11 year: 2009 ident: 9305_CR58 publication-title: Nat Med doi: 10.1038/nm.2049 – volume: 61C start-page: 85 year: 2013 ident: 9305_CR59 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.03.007 – volume: 31 start-page: S185 issue: Suppl 2 year: 2008 ident: 9305_CR87 publication-title: Diabetes Care doi: 10.2337/dc08-s246 – volume: 55 start-page: S9 issue: Supplement 2 year: 2006 ident: 9305_CR21 publication-title: Diabetes doi: 10.2337/db06-S002 – volume: 119 start-page: 573 issue: 3 year: 2009 ident: 9305_CR19 publication-title: J Clin Invest doi: 10.1172/JCI37048 – volume: 60 start-page: 2683 issue: 11 year: 2011 ident: 9305_CR14 publication-title: Diabetes doi: 10.2337/db11-1072 – volume: 27 start-page: 441 issue: 4 year: 2013 ident: 9305_CR54 publication-title: Genes Dev doi: 10.1101/gad.201731.112 – volume: 30 start-page: 1024 issue: 6 year: 2009 ident: 9305_CR60 publication-title: Carcinogenesis doi: 10.1093/carcin/bgp100 – volume: 59 start-page: 739 year: 2013 ident: 9305_CR47 publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2013.07.032 – volume: 40 start-page: 229 issue: 4 year: 2005 ident: 9305_CR73 publication-title: Crit Rev Biochem Mol Biol doi: 10.1080/10409230591008189 – volume: 73 start-page: 31 issue: 1 year: 2005 ident: 9305_CR74 publication-title: Prostaglandins Leukot Essent Fatty Acids doi: 10.1016/j.plefa.2005.04.004 – volume: 26 start-page: 1 issue: 1 year: 2007 ident: 9305_CR25 publication-title: Mol Cell doi: 10.1016/j.molcel.2007.03.016 – volume: 620 start-page: 138 issue: 1–3 year: 2009 ident: 9305_CR46 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2009.08.022 – volume: 333 start-page: 140 issue: 1 year: 2010 ident: 9305_CR85 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.109.162271 – volume: 17 start-page: 2578 issue: 19 year: 2013 ident: 9305_CR56 publication-title: Eur Rev Med Pharmacol Sci – volume: 123 start-page: 590 issue: 2 year: 2011 ident: 9305_CR63 publication-title: Toxicol Sci doi: 10.1093/toxsci/kfr183 – volume: 20 start-page: 2114 issue: 14 year: 2014 ident: 9305_CR72 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2013.5428 – volume: 118 start-page: 789 issue: 2 year: 2008 ident: 9305_CR17 publication-title: J Clin Invest – volume: 285 start-page: 9292 issue: 12 year: 2010 ident: 9305_CR40 publication-title: J Biol Chem doi: 10.1074/jbc.M109.093955 – volume: 276 start-page: 22559 issue: 25 year: 2001 ident: 9305_CR33 publication-title: J Biol Chem doi: 10.1074/jbc.M101053200 – volume: 25 start-page: 492 issue: 3 year: 2011 ident: 9305_CR7 publication-title: Mol Endocrinol doi: 10.1210/me.2010-0224 – volume: 371 start-page: 569 issue: 9612 year: 2008 ident: 9305_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(08)60269-X – volume: 27 start-page: 7188 issue: 20 year: 2007 ident: 9305_CR80 publication-title: Mol Cell Biol doi: 10.1128/MCB.00915-07 – volume: 235 start-page: 57 issue: 1 year: 2009 ident: 9305_CR84 publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2008.11.007 – volume: 359 start-page: 2105 issue: 20 year: 2008 ident: 9305_CR4 publication-title: N Engl J Med doi: 10.1056/NEJMoa0801891 – volume: 276 start-page: 31099 issue: 33 year: 2001 ident: 9305_CR23 publication-title: J Bio Chem doi: 10.1074/jbc.M104115200 – volume: 101 start-page: 2040 issue: 7 year: 2004 ident: 9305_CR12 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0307301101 – volume: 10 start-page: 260 issue: 4 year: 2009 ident: 9305_CR15 publication-title: Cell Metab doi: 10.1016/j.cmet.2009.08.009 – volume: 106 start-page: 8665 issue: 21 year: 2009 ident: 9305_CR26 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0903485106 – volume: 348 start-page: 182 year: 2002 ident: 9305_CR13 publication-title: Methods Enzymol doi: 10.1016/S0076-6879(02)48637-5 – volume: 1801 start-page: 338 issue: 3 year: 2010 ident: 9305_CR76 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbalip.2009.12.006 – volume: 62 start-page: 845 issue: 3 year: 2013 ident: 9305_CR43 publication-title: Diabetes doi: 10.2337/db12-0584 – volume: 63 start-page: 605 issue: 2 year: 2014 ident: 9305_CR86 publication-title: Diabetes doi: 10.2337/db13-0909 – volume: 42 start-page: 563 issue: 6 year: 2012 ident: 9305_CR3 publication-title: Am J Prev Med doi: 10.1016/j.amepre.2011.10.026 – volume: 26 start-page: 593 issue: 7–8 year: 2004 ident: 9305_CR88 publication-title: Clin Exp Hypertens doi: 10.1081/CEH-200031904 – volume: 52 start-page: 70 issue: 1 year: 2012 ident: 9305_CR90 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2011.09.015 – ident: 9305_CR32 doi: 10.1016/j.advenzreg.2006.01.007 – volume: 73 start-page: 1612 issue: 8 year: 2010 ident: 9305_CR62 publication-title: J Proteomics doi: 10.1016/j.jprot.2010.03.018 – volume: 55 start-page: 773 issue: 3 year: 2012 ident: 9305_CR83 publication-title: Diabetologia doi: 10.1007/s00125-011-2396-x – volume: 297 start-page: 842 issue: 8 year: 2007 ident: 9305_CR31 publication-title: J Am Med Assoc doi: 10.1001/jama.297.8.842 – volume: 40 start-page: 7416 issue: 15 year: 2012 ident: 9305_CR81 publication-title: Nucleic Acids Res doi: 10.1093/nar/gks409 – volume: 106 start-page: 17787 issue: 42 year: 2009 ident: 9305_CR50 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0902380106 – volume: 4 start-page: 62 issue: 1 year: 2013 ident: 9305_CR77 publication-title: Adv Nutr doi: 10.3945/an.112.003103 – volume: 52 start-page: 462 issue: 2 year: 2012 ident: 9305_CR78 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2011.10.453 – volume: 53 start-page: 2008 issue: 11 year: 2012 ident: 9305_CR52 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2012.09.025 – volume: 257 start-page: 338 issue: 3 year: 2011 ident: 9305_CR34 publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2011.09.017 – volume: 52 start-page: 1708 issue: 9 year: 2012 ident: 9305_CR42 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2012.02.022 – volume: 8 start-page: 57 issue: 1 year: 2014 ident: 9305_CR28 publication-title: Diabetes Metab Syndr doi: 10.1016/j.dsx.2013.10.004 – volume: 299 start-page: G1211 issue: 6 year: 2010 ident: 9305_CR65 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00322.2010 – volume: 440 start-page: 944 issue: 7086 year: 2006 ident: 9305_CR18 publication-title: Nature doi: 10.1038/nature04634 – volume: 43 start-page: 862 issue: 6 year: 2011 ident: 9305_CR75 publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2011.03.002 – volume: 36 start-page: 1503 issue: 12 year: 2012 ident: 9305_CR30 publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2011.279 – volume: 16 start-page: 123 issue: 2 year: 2011 ident: 9305_CR10 publication-title: Genes Cells doi: 10.1111/j.1365-2443.2010.01473.x – volume: 7 start-page: 25 issue: 1 year: 2013 ident: 9305_CR37 publication-title: Front Med doi: 10.1007/s11684-013-0244-8 – volume: 383 start-page: 841 issue: 9919 year: 2014 ident: 9305_CR29 publication-title: Lancet doi: 10.1016/S0140-6736(13)62365-X – volume: 21 start-page: 689 issue: 5 year: 2006 ident: 9305_CR9 publication-title: Mol Cell doi: 10.1016/j.molcel.2006.01.013 – volume: 278 start-page: 21592 issue: 24 year: 2003 ident: 9305_CR11 publication-title: J Biol Chem doi: 10.1074/jbc.M300931200 – volume: 245 start-page: 326 issue: 3 year: 2010 ident: 9305_CR69 publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2010.03.016 – volume: 325 start-page: 655 issue: 2 year: 2008 ident: 9305_CR16 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.107.135822 – volume: 5 start-page: 1165 issue: 8 year: 2013 ident: 9305_CR79 publication-title: EMBO Mol Med doi: 10.1002/emmm.201302679 – volume: 90 start-page: 315 issue: 2 year: 2011 ident: 9305_CR91 publication-title: Cardiovasc Res doi: 10.1093/cvr/cvr010 – volume: 264 start-page: 305 issue: 3 year: 2012 ident: 9305_CR39 publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2012.09.014 – volume: 61 start-page: 3208 issue: 12 year: 2012 ident: 9305_CR45 publication-title: Diabetes doi: 10.2337/db11-1716 – volume: 50 start-page: 404 issue: 2 year: 2001 ident: 9305_CR8 publication-title: Diabetes doi: 10.2337/diabetes.50.2.404 – volume: 29 start-page: 75 issue: 2 year: 2013 ident: 9305_CR71 publication-title: Cell Biol Toxicol doi: 10.1007/s10565-013-9239-0 – volume: 15 start-page: 2135 issue: 8 year: 2011 ident: 9305_CR64 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2010.3834 – volume: 14 start-page: 2684 issue: 2 year: 2013 ident: 9305_CR89 publication-title: Int J Mol Sci doi: 10.3390/ijms14022684 – volume: 25 start-page: 201 issue: 2 year: 2014 ident: 9305_CR55 publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2013.10.007 – volume: 91 start-page: 254S issue: 1 year: 2010 ident: 9305_CR38 publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.28449B – volume: 271 start-page: 95 issue: 1 year: 2013 ident: 9305_CR70 publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2013.04.023 – reference: 21775727 - Toxicol Sci. 2011 Oct;123(2):590-600 – reference: 14764894 - Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5 – reference: 23431056 - Genes Dev. 2013 Feb 15;27(4):441-9 – reference: 18188455 - J Clin Invest. 2008 Feb;118(2):789-800 – reference: 23358894 - Front Med. 2013 Mar;7(1):25-30 – reference: 19188683 - J Clin Invest. 2009 Mar;119(3):573-81 – reference: 17434122 - Mol Cell. 2007 Apr 13;26(1):1-14 – reference: 20930048 - Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1211-21 – reference: 23828861 - EMBO Mol Med. 2013 Aug;5(8):1165-79 – reference: 12682069 - J Biol Chem. 2003 Jun 13;278(24):21592-600 – reference: 23145499 - Br J Pharmacol. 2013 Apr;168(7):1647-61 – reference: 18280327 - Lancet. 2008 Feb 16;371(9612):569-78 – reference: 22370093 - Free Radic Biol Med. 2012 May 1;52(9):1708-15 – reference: 18227483 - Diabetes Care. 2008 Feb;31 Suppl 2:S185-9 – reference: 11885271 - Methods Enzymol. 2002;348:182-90 – reference: 23651738 - Toxicol Appl Pharmacol. 2013 Aug 15;271(1):95-105 – reference: 19808019 - Cell Metab. 2009 Oct;10(4):260-72 – reference: 24733068 - Int J Mol Sci. 2014 Apr 11;15(4):6184-223 – reference: 16612386 - Nature. 2006 Apr 13;440(7086):944-8 – reference: 23419601 - Int J Obes (Lond). 2013 Oct;37(10):1386-90 – reference: 20056169 - Biochim Biophys Acta. 2010 Mar;1801(3):338-49 – reference: 23871787 - Food Chem Toxicol. 2013 Sep;59:739-47 – reference: 22581777 - Nucleic Acids Res. 2012 Aug;40(15):7416-29 – reference: 22159911 - Diabetologia. 2012 Mar;55(3):773-82 – reference: 17327526 - JAMA. 2007 Feb 28;297(8):842-57 – reference: 22138520 - Free Radic Biol Med. 2012 Jan 15;52(2):462-72 – reference: 22608371 - Am J Prev Med. 2012 Jun;42(6):563-70 – reference: 19386581 - Carcinogenesis. 2009 Jun;30(6):1024-31 – reference: 23022408 - Free Radic Biol Med. 2012 Dec 1;53(11):2008-16 – reference: 19071154 - Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67 – reference: 16126487 - Crit Rev Biochem Mol Biol. 2005 Jul-Aug;40(4):229-42 – reference: 20350562 - Toxicol Appl Pharmacol. 2010 Jun 15;245(3):326-34 – reference: 23716596 - Mol Cell Biol. 2013 Aug;33(15):2996-3010 – reference: 23319124 - Adv Nutr. 2013 Jan 01;4(1):62-6 – reference: 20089859 - J Biol Chem. 2010 Mar 19;285(12):9292-300 – reference: 24281010 - J Endocrinol. 2014 Jan 08;220(2):T1-T23 – reference: 23238296 - Diabetes. 2013 Mar;62(3):845-54 – reference: 17709388 - Mol Cell Biol. 2007 Oct;27(20):7188-97 – reference: 16507366 - Mol Cell. 2006 Mar 3;21(5):689-700 – reference: 23023374 - Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2839-46 – reference: 21161163 - Diabetologia. 2011 Apr;54(4):922-34 – reference: 23507082 - Free Radic Biol Med. 2013 Aug;61:85-94 – reference: 11390407 - J Biol Chem. 2001 Aug 17;276(33):31099-104 – reference: 23239837 - Circulation. 2013 Jan 1;127(1):e6-e245 – reference: 23463459 - Cell Biol Toxicol. 2013 Apr;29(2):75-84 – reference: 24445045 - J Nutr Biochem. 2014 Feb;25(2):201-7 – reference: 14966267 - Mol Cell Biol. 2004 Mar;24(5):1844-54 – reference: 23663741 - Cell Metab. 2013 May 7;17(5):779-89 – reference: 20086057 - J Pharmacol Exp Ther. 2010 Apr;333(1):140-51 – reference: 19433800 - Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70 – reference: 15936931 - Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):31-4 – reference: 15184668 - Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8852-7 – reference: 19805130 - Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92 – reference: 21504366 - Antioxid Redox Signal. 2011 Oct 15;15(8):2135-46 – reference: 23878368 - J Physiol. 2013 Oct 15;591(20):5047-59 – reference: 23017736 - Toxicol Appl Pharmacol. 2012 Nov 1;264(3):305-14 – reference: 24581668 - Lancet. 2014 Mar 1;383(9919):841-3 – reference: 19906798 - Am J Clin Nutr. 2010 Jan;91(1):254S-257S – reference: 21239612 - Mol Endocrinol. 2011 Mar;25(3):492-502 – reference: 19838201 - Nat Med. 2009 Nov;15(11):1307-11 – reference: 20399915 - J Proteomics. 2010 Jun 16;73(8):1612-31 – reference: 23358254 - Int J Mol Sci. 2013 Jan 28;14(2):2684-706 – reference: 16887173 - Adv Enzyme Regul. 2006;46:113-40 – reference: 24142602 - Eur Rev Med Pharmacol Sci. 2013 Oct;17(19):2578-86 – reference: 18281592 - J Pharmacol Exp Ther. 2008 May;325(2):655-64 – reference: 22645638 - World J Diabetes. 2012 May 15;3(5):94-104 – reference: 23631497 - J Med Food. 2013 May;16(5):375-82 – reference: 21392585 - Int J Biochem Cell Biol. 2011 Jun;43(6):862-76 – reference: 17130651 - Diabetes. 2006 Dec;55 Suppl 2:S9-S15 – reference: 11557972 - Nature. 2001 Sep 13;413(6852):131-8 – reference: 22025774 - Diabetes. 2011 Nov;60(11):2683-4 – reference: 22001745 - Free Radic Biol Med. 2012 Jan 1;52(1):70-9 – reference: 19005195 - N Engl J Med. 2008 Nov 13;359(20):2105-20 – reference: 24661761 - Diabetes Metab Syndr. 2014 Jan-Mar;8(1):57-61 – reference: 22430302 - Int J Obes (Lond). 2012 Dec;36(12):1503-13 – reference: 24252128 - Antioxid Redox Signal. 2014 May 10;20(14):2114-29 – reference: 22936178 - Diabetes. 2012 Dec;61(12 ):3208-18 – reference: 24186865 - Diabetes. 2014 Feb;63(2):605-18 – reference: 23213463 - Biol Open. 2012 Aug 15;1(8):705-10 – reference: 21251164 - Genes Cells. 2011 Feb;16(2):123-40 – reference: 21967773 - Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48 – reference: 19698707 - Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44 – reference: 10187855 - J Biol Chem. 1999 Apr 9;274(15):10595-602 – reference: 21245055 - Cardiovasc Res. 2011 May 1;90(2):315-24 – reference: 11309386 - J Biol Chem. 2001 Jun 22;276(25):22559-64 – reference: 15702613 - Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):593-601 – reference: 21109199 - Cell Metab. 2010 Dec 1;12(6):668-74 – reference: 21872749 - Lancet. 2011 Aug 27;378(9793):804-14 – reference: 19955654 - J Clin Invest. 2010 Jan;120(1):203-13 – reference: 11272154 - Diabetes. 2001 Feb;50(2):404-10 – reference: 21852674 - Diabetes. 2011 Oct;60(10):2465-73
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Snippet	Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and... Issue Title: Inflammation and ROS in Insulin Resistance Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may...
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SubjectTerms	Diabetes Endocrinology Homeostasis - physiology Humans Insulin Resistance - physiology Internal Medicine Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 Medicine Medicine & Public Health Metabolic Syndrome - metabolism NF-E2-Related Factor 2 - metabolism Obesity - metabolism Reactive Oxygen Species - metabolism Signal Transduction - physiology
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Title	The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome
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