Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

• Published in: Journal of biomedical science Vol. 30; no. 1; pp. 1 - 19
• Main Authors: Liu, Lei, Li, Yanjun, Chen, Guo, Chen, Quan
• Format: Journal Article
• Language: English
• Published: Basel BioMed Central Ltd 12.10.2023; BioMed Central; BMC
• Subjects: Age related diseases; Aging; Aging-related diseases; Binding sites; Biosynthesis; Cell division; Cytochrome; Estrogens; Gene expression; Homeostasis; Kinases; Mitochondria; Mitochondrial biogenesis; Mitochondrial DNA; Mitochondrial quality; Mitophagy; Mitophagy receptors; Musculoskeletal system; Proteins; Review; Thermogenesis; Transcription factors; France; China

Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. Great strides have been made to uncover key regulators of these comp...