Urinary exosomal miRNA-663a shows variable expression in diabetic kidney disease patients with or without proteinuria

• Published in: Scientific reports Vol. 13; no. 1; pp. 4516 - 13
• Main Authors: Sinha, Nisha, Puri, Veena, Kumar, Vivek, Nada, Ritambhra, Rastogi, Ashu, Jha, Vivekanand, Puri, Sanjeev
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 692/4022; Bioinformatics; Cell Line; Diabetes; Diabetes Mellitus; Diabetic Nephropathies - metabolism; Diabetic nephropathy; Gene mapping; Heterogeneity; Humanities and Social Sciences; Humans; Inflammation; Interleukin 8; Kidney - metabolism; Kidney diseases; Kidneys; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; multidisciplinary; Proteinuria; Science; Science (multidisciplinary); Signal Transduction

Heterogeneity in the Diabetic Kidney Disease (DKD) diagnosis makes its rational therapeutics challenging. Although albuminuria characterizes DKD, reports also indicate its prevalence among non-proteinuric. Recent understanding of disease progression has thus inclined the focus on proximal tubular ce...