Dynamic changes in macrophage morphology during the progression of choroidal neovascularization in a laser-induced choroidal neovascularization mouse model

• Published in: BMC ophthalmology Vol. 23; no. 1; pp. 1 - 401
• Main Authors: Xu, Nana, Sun, Tao, Wang, Yulan, Tong, Xiaowei, Lu, Shiheng, Yang, Fan, Wang, Jing, Bo, Qiyu, Sun, Junran, Sun, Xiaodong
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 06.10.2023; BioMed Central; BMC
• Subjects: Age; Angiogenesis; Antibodies; Choroidal neovascularization; Genotype & phenotype; Immunofluorescence; Laboratory animals; Lasers; Macrophage; Macrophages; Macular degeneration; Morphology; Neovascularization; Ophthalmology; Phenotypes; Stem cells; Vascular endothelial growth factor; Vascularization; Western blotting; China; United States > US; Germany

Abstract Background Neovascular age-related macular degeneration (AMD) is responsible for the majority of severe vision loss cases and is mainly caused by choroidal neovascularization (CNV). This condition persists or recurs in a subset of patients and regresses after 5 or more years of anti-vascula...