Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy

• Published in: Acta neuropathologica Vol. 140; no. 5; pp. 659 - 674
• Main Authors: Katsumata, Yuriko, Abner, Erin L., Karanth, Shama, Teylan, Merilee A., Mock, Charles N., Cykowski, Matthew D., Lee, Edward B., Boehme, Kevin L., Mukherjee, Shubhabrata, Kauwe, John S. K., Kryscio, Richard J., Schmitt, Frederick A., Fardo, David W., Nelson, Peter T.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2020; Springer; Springer Nature B.V
• Subjects: Age; Age Factors; Aged; Aged, 80 and over; Algorithms; Alzheimer's disease; Amyloid; Aphasia; Appetite; Autopsy; Brain; Cluster Analysis; Cognitive ability; Death; Degeneration; Dementia; Dementia disorders; Emotional behavior; Encephalopathy; Female; Frontotemporal dementia; Frontotemporal Dementia - classification; Frontotemporal Dementia - pathology; Humans; Lewy bodies; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Neurodegenerative diseases; Neuropathology; Neurosciences; Original Paper; Pathology; Phenotypes; Senile plaques; Single nucleotide polymorphisms; TDP-43 Proteinopathies - classification; TDP-43 Proteinopathies - pathology; Psychosis; Anxiety; Trajectory; DLB; Hallucinations; FTD

To better understand clinical and neuropathological features of TDP-43 proteinopathies, data were analyzed from autopsied research volunteers who were followed in the National Alzheimer’s Coordinating Center (NACC) data set. All subjects ( n  = 495) had autopsy-proven TDP-43 proteinopathy as an incl...