Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces

• Published in: Nature (London) Vol. 611; no. 7937; pp. 787 - 793
• Main Authors: Tsou, Amy M., Yano, Hiroshi, Parkhurst, Christopher N., Mahlakõiv, Tanel, Chu, Coco, Zhang, Wen, He, Zhengxiang, Jarick, Katja J., Zhong, Connie, Putzel, Gregory G., Hatazaki, Mai, Lorenz, Ivo C., Andrew, David, Balderes, Paul, Klose, Christoph S. N., Lira, Sergio A., Artis, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.11.2022; Nature Publishing Group
• Subjects: 14; 14/19; 14/35; 38/1; 38/77; 631/250/2504/2506; 631/250/371; 64/110; 64/60; 692/699/1503/257; Adaptive systems; Amphiregulin; Animals; Antiinfectives and antibacterials; Cholinergics; Colon; Cytokines; Cytokines - immunology; Cytokines - metabolism; Depletion; Gene deletion; Granulocytes; Homeostasis; Humanities and Social Sciences; Humans; Immune system; Immunity; Immunity, Innate - immunology; Infections; Inflammation; Inflammation - immunology; Inflammation - parasitology; Inflammation - pathology; Intestinal Mucosa - immunology; Intestinal Mucosa - parasitology; Intestinal Mucosa - pathology; Intestine; Lymphocytes; Lymphocytes - immunology; Lymphoid cells; Mice; multidisciplinary; Neuromedin; Neuropeptides; Neuropeptides - metabolism; Neuropeptides - physiology; Recombinase; Redundancy; Science; Science (multidisciplinary); Small intestine; Spleen; Transgenic animals

Emerging studies indicate that cooperation between neurons and immune cells regulates antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal rheostat provides excitatory or inhibitory signals that control the functions of tissue-resident group 2 innate lymphoid cells (I...