Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines

• Published in: Psychopharmacology Vol. 239; no. 1; pp. 229 - 242
• Main Authors: Moudio, Serge, Willis, Ashleigh, Pytka, Karolina, Abulkassim, Roua, Brett, Ros R., Webster, Jack F., Wozny, Christian, Barbour, Mark, Jiang, Hui-Rong, Watson, David G., van Kralingen, Josie C., MacKenzie, Scott M., Daniels, Michael, McColl, Barry W., Sossick, Sandra, Nuthall, Hugh N., Bushell, Trevor J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blood-brain barrier; Cell receptors; Cytokines; Depression; Depressive Disorder, Major; Development and progression; Drug therapy; Gene expression; Habenula; Health aspects; Humans; Inflammation; Injection; Interleukin 6; Locomotor activity; Lymphocytes; Major depressive disorder; Mental depression; Mice; Microglia; Neurosciences; Open-field behavior; Original Investigation; Par-2 protein; Pattern recognition; Pharmacology/Toxicology; Psychiatry; Receptor, PAR-2; Sickness behavior; Sucrose; United Kingdom; Open-field test; Inflammation; Protease-activated receptor-2; Cytokines; Sucrose preference

Rationale Major depressive disorder (MDD) is a leading cause of disability worldwide but currently prescribed treatments do not adequately ameliorate the disorder in a significant portion of patients. Hence, a better appreciation of its aetiology may lead to the development of novel therapies. Objec...