Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines - Moudio, Serge; Willis, Ashleigh; Pytka, Karolina; Abulkassim, Roua; Brett, Ros R.; Webster, Jack F.; Wozny, Christian; Barbour, Mark; Jiang, Hui-Rong; Watson, David G.; van Kralingen, Josie C.; MacKenzie, Scott M.; et al. (Psychopharmacology, 2022)
Keywords: Animals; Biomedical and Life Sciences; Biomedicine; Blood-brain barrier; Cell receptors; Cytokines; Depression; Depressive Disorder, Major; Development and progression; Drug therapy; Gene expression; Habenula; Health aspects; Humans; Inflammation; Injection; Interleukin 6; Locomotor activity; Lymphocytes; Major depressive disorder; Mental depression; Mice; Microglia; Neurosciences; Open-field behavior; Original Investigation; Par-2 protein; Pattern recognition; Pharmacology/Toxicology; Psychiatry; Receptor, PAR-2; Sickness behavior; Sucrose; United Kingdom; Open-field test; Inflammation; Protease-activated receptor-2; Cytokines; Sucrose preference