Genome-wide association study of metabolic dysfunction-associated fatty liver disease in a Korean population

• Published in: Scientific reports Vol. 14; no. 1; pp. 9753 - 9
• Main Authors: Lee, Young, Cho, Eun Ju, Choe, Eun Kyung, Kwak, Min-Sun, Yang, Jong In, Oh, Seung-Won, Yim, Jeong Yoon, Chung, Goh Eun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4020/4021; 692/4020/4021/288; Acyltransferases; Adult; Aged; Alleles; Body weight; Case-Control Studies; Fatty liver; Female; Genetic diversity; Genetic factors; Genetic Predisposition to Disease; Genetic variance; Genome-wide association studies; Genome-Wide Association Study; Genomes; Humanities and Social Sciences; Humans; Lipase - genetics; Liver; Liver diseases; Male; Membrane Proteins - genetics; Metabolic fatty liver disease; Metabolism; Middle Aged; multidisciplinary; Non-alcoholic Fatty Liver Disease - epidemiology; Non-alcoholic Fatty Liver Disease - genetics; Obesity; Obesity - genetics; Overweight; Phospholipases A2, Calcium-Independent; Polymorphism, Single Nucleotide; Population studies; Ratios; Republic of Korea - epidemiology; Science; Science (multidisciplinary); Single-nucleotide polymorphism; SNP; Republic of Korea; Genome-wide association study; SNP; Metabolic fatty liver disease

Genome-wide association studies have identified several genetic variants associated with nonalcoholic fatty liver disease. To emphasize metabolic abnormalities in fatty liver, metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been introduced; thus, we aimed to investigate single-nuc...