Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis - Meyer, Urs; Knuesel, Irene; Nyffeler, Myriel; Feldon, Joram (Psychopharmacologia, 2010)
Keywords: Adult and adolescent clinical studies; Animals; Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cell Count - methods; Clozapine - administration & dosage; Clozapine - pharmacology; Clozapine - therapeutic use; Cognition & reasoning; Disease Models, Animal; Female; Hippocampus - drug effects; Hippocampus - physiology; Infections; Male; Medical sciences; Memory Disorders - chemically induced; Memory Disorders - complications; Memory Disorders - drug therapy; Memory Disorders - physiopathology; Memory, Short-Term - drug effects; Mice; Mice, Inbred C57BL; Neurogenesis - drug effects; Neurogenesis - physiology; Neuropharmacology; Neurosciences; Original Investigation; Pharmacology. Drug treatments; Pharmacology/Toxicology; Polynucleotides - adverse effects; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - therapy; Prenatal development; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - drug therapy; Prenatal Exposure Delayed Effects - immunology; Prenatal Exposure Delayed Effects - psychology; Psychiatry; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Psychotropic drugs; Rodents; Schizophrenia; Infection; Schizophrenia; Animal model; Cognition; Antipsychotic drugs; Hippocampus; Memory disorder; Dibenzodiazepine derivatives; Cognitive disorder; Atypical antipsychotic; Neuroleptic; Psychotropic; Central nervous system; Pharmacotherapy; Neurogenesis; Encephalon; Psychosis; Prenatal; Adult; Antagonist; Human; Drug; Clozapine; Injection; Chronic; D2 Dopamine receptor; Treatment; Working memory