RELEASE (REdressing Long-tErm Antidepressant uSE): protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 in general practice

• Published in: Current controlled trials in cardiovascular medicine Vol. 24; no. 1; p. 615
• Main Authors: Wallis, Katharine A, Donald, Maria, Horowitz, Mark, Moncrieff, Joanna, Ware, Robert S, Byrnes, Joshua, Thrift, Karen, Cleetus, MaryAnne, Panahi, Idin, Zwar, Nicholas, Morgan, Mark, Freeman, Chris, Scott, Ian
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 28.09.2023; BioMed Central; BMC
• Subjects: Analysis; Antidepressants; Automation; Clinical practice guidelines; Consent; Deprescribing; Discontinuation; Dosage and administration; Drug dosages; Drug withdrawal; Elder care; Falls (Accidents); Family medicine; Health care reform; Intervention; Medical care, Cost of; Medical practice software; Medical research; Mental health; Patient outcomes; Patients; Physicians (General practice); Primary care; Psychotherapy; Psychotropic drugs; R&D; Research & development; Services; Sexual disorders; Study Protocol; Tapering; Well being; Withdrawal; Australia; Queensland Australia; United Kingdom > UK

Background Many people experience withdrawal symptoms when they attempt to stop antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing need for medication, contributing to long-term use (> 12 months). Long-term antidepressant use is increasing internationally yet is...