PKM2 aggregation drives metabolism reprograming during aging process

• Published in: Nature communications Vol. 15; no. 1; pp. 5761 - 16
• Main Authors: Bie, Juntao, Li, Ridong, Li, Yutong, Song, Chen, Chen, Zhaoming, Zhang, Tianzhuo, Tang, Zhiheng, Su, Li, Zhu, Liangyi, Wang, Jiaxin, Wan, You, Chen, Jun, Liu, Xiaoyun, Li, Tingting, Luo, Jianyuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 14/19; 14/35; 38/91; 631/154/555; 631/80/470/2284; 631/80/509; 64/60; 82/80; Age related diseases; Aggregates; Aging; Aging - metabolism; Animals; Carrier Proteins - metabolism; Cellular Senescence; Driving ability; Enzymatic activity; Glycolysis; Humanities and Social Sciences; Humans; Life span; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; multidisciplinary; Phenotypes; Protein Aggregates; Protein interaction; Protein turnover; Proteins; Pyruvate Kinase - metabolism; Science; Science (multidisciplinary); Senescence; Thyroid Hormone-Binding Proteins; Thyroid Hormones - metabolism

While protein aggregation’s association with aging and age-related diseases is well-established, the specific proteins involved and whether dissolving them could alleviate aging remain unclear. Our research addresses this gap by uncovering the role of PKM2 aggregates in aging. We find that PKM2 form...