Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

• Published in: Nature communications Vol. 15; no. 1; pp. 4233 - 18
• Main Authors: Faget, Lauren, Oriol, Lucie, Lee, Wen-Chun, Zell, Vivien, Sargent, Cody, Flores, Andrew, Hollon, Nick G., Ramanathan, Dhakshin, Hnasko, Thomas S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1662; 631/378/1788; 631/378/3920; 64/60; 82/1; 82/51; 96/10; 96/35; 96/44; 96/63; Animals; Aversion; Avoidance; Avoidance behavior; Avoidance Learning - physiology; Basal Forebrain - metabolism; Basal Forebrain - physiology; Behavior, Animal - physiology; Dopamine; Dopamine - metabolism; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - physiology; GABAergic Neurons - metabolism; GABAergic Neurons - physiology; gamma-Aminobutyric Acid - metabolism; Globus pallidus; Glutamic Acid - metabolism; Humanities and Social Sciences; Hypothalamus (ventromedial); Male; Mice; Mice, Inbred C57BL; multidisciplinary; Neurons; Neurons - metabolism; Neurons - physiology; Nucleus accumbens; Nucleus Accumbens - cytology; Nucleus Accumbens - metabolism; Nucleus Accumbens - physiology; Pallidum (ventral); Reinforcement; Reward; Science; Science (multidisciplinary); Stimulation; Ventral Tegmental Area - cytology; Ventral Tegmental Area - metabolism; Ventral Tegmental Area - physiology; Ventral tegmentum; γ-Aminobutyric acid

The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP G...