Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP G...

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Published inNature communications Vol. 15; no. 1; pp. 4233 - 18
Main Authors Faget, Lauren, Oriol, Lucie, Lee, Wen-Chun, Zell, Vivien, Sargent, Cody, Flores, Andrew, Hollon, Nick G., Ramanathan, Dhakshin, Hnasko, Thomas S.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 18.05.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/378/1662
631/378/1788
631/378/3920
64/60
82/1
82/51
96/10
96/35
96/44
96/63
Animals
Aversion
Avoidance
Avoidance behavior
Avoidance Learning - physiology
Basal Forebrain - metabolism
Basal Forebrain - physiology
Behavior, Animal - physiology
Dopamine
Dopamine - metabolism
Dopaminergic Neurons - metabolism
Dopaminergic Neurons - physiology
GABAergic Neurons - metabolism
GABAergic Neurons - physiology
gamma-Aminobutyric Acid - metabolism
Globus pallidus
Glutamic Acid - metabolism
Humanities and Social Sciences
Hypothalamus (ventromedial)
Male
Mice
Mice, Inbred C57BL
multidisciplinary
Neurons
Neurons - metabolism
Neurons - physiology
Nucleus accumbens
Nucleus Accumbens - cytology
Nucleus Accumbens - metabolism
Nucleus Accumbens - physiology
Pallidum (ventral)
Reinforcement
Reward
Science
Science (multidisciplinary)
Stimulation
Ventral Tegmental Area - cytology
Ventral Tegmental Area - metabolism
Ventral Tegmental Area - physiology
Ventral tegmentum
γ-Aminobutyric acid
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-024-48340-y

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Abstract The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject’s own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors. Ventral pallidum GABA and glutamate neuron activation drives approach and avoidance, respectively. Here, the authors show that both ventral pallidum cell types are activated during approach to reward and by aversive stimuli, but elicit opponent effects on VTA cell-type activity.
AbstractList The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject’s own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors.Ventral pallidum GABA and glutamate neuron activation drives approach and avoidance, respectively. Here, the authors show that both ventral pallidum cell types are activated during approach to reward and by aversive stimuli, but elicit opponent effects on VTA cell-type activity.
The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject's own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors.The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject's own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors.
The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject's own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors.
The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject’s own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors. Ventral pallidum GABA and glutamate neuron activation drives approach and avoidance, respectively. Here, the authors show that both ventral pallidum cell types are activated during approach to reward and by aversive stimuli, but elicit opponent effects on VTA cell-type activity.
Abstract The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject’s own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors.
ArticleNumber 4233
Author Lee, Wen-Chun
Faget, Lauren
Sargent, Cody
Ramanathan, Dhakshin
Oriol, Lucie
Hnasko, Thomas S.
Hollon, Nick G.
Zell, Vivien
Flores, Andrew
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38762463$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nn.3664
10.1002/jnr.22265
10.1002/(SICI)1096-9861(19960108)364:2<340::AID-CNE11>3.0.CO;2-T
10.1016/j.biopsych.2018.01.003
10.1016/j.celrep.2016.05.057
10.1016/S0006-8993(99)01239-1
10.1111/bph.15160
10.1523/JNEUROSCI.0262-19.2019
10.1016/j.celrep.2019.03.055
10.1523/JNEUROSCI.1437-03.2004
10.1038/s41467-018-03125-y
10.1523/JNEUROSCI.1570-13.2013
10.1016/j.scib.2019.11.029
10.1523/JNEUROSCI.20-10-03864.2000
10.1038/nature10754
10.1113/jphysiol.2008.153643
10.1152/jn.00576.2006
10.1016/0306-4522(93)90115-V
10.1111/ejn.12818
10.1016/j.bbr.2015.11.024
10.1016/j.celrep.2020.108094
10.1126/science.aat4422
10.1016/0301-0082(80)90018-0
10.1016/0166-4328(94)00169-G
10.1523/JNEUROSCI.4336-13.2014
10.1126/science.275.5306.1593
10.1038/srep20231
10.1016/j.bbr.2008.09.038
10.1016/j.conb.2020.02.002
10.1016/j.tins.2020.01.004
10.1038/s41593-019-0506-0
10.1523/JNEUROSCI.2822-18.2018
10.3389/fnins.2012.00137
10.1523/JNEUROSCI.2659-16.2016
10.1016/j.neuron.2021.05.002
10.1016/0006-8993(93)90053-P
10.1523/JNEUROSCI.2693-17.2018
10.1016/j.ijdevneu.2010.08.002
10.1002/syn.20990
10.1152/jn.2000.83.5.2649
10.1016/j.neuron.2020.06.011
10.1016/j.neuron.2010.11.022
10.1016/j.neuron.2016.04.035
10.1523/JNEUROSCI.2580-16.2016
10.4172/2155-9899.1000492
10.1523/JNEUROSCI.1902-05.2005
10.1038/s41586-019-1235-y
10.1523/JNEUROSCI.0736-16.2016
10.1038/18019
10.1038/s41386-019-0507-4
10.1016/j.cell.2015.01.003
10.1016/j.conb.2020.10.012
10.3389/fnsys.2022.1009626
10.1038/nn1103
10.1016/j.neuron.2015.08.037
10.1016/j.neuron.2019.12.006
10.1523/JNEUROSCI.0012-07.2007
10.1016/j.neuron.2016.09.001
10.1038/s41593-022-01152-z
10.1016/j.cell.2015.07.014
10.1016/0306-4522(91)90202-Y
10.1002/syn.20792
10.1073/pnas.1101920108
10.1038/ncomms13697
10.1016/j.neuron.2016.08.018
10.1038/s41593-020-0688-5
10.1016/j.pneurobio.2015.03.005
10.1016/j.neuron.2016.04.037
10.1523/JNEUROSCI.1262-19.2019
10.1016/j.neuron.2011.03.025
10.1016/j.neuron.2018.11.005
10.1038/s41593-020-0657-z
10.1016/S0006-8993(01)02581-1
10.1016/j.celrep.2018.05.063
10.1038/nn.3283
10.1016/j.bbr.2014.05.032
10.1016/j.neubiorev.2021.09.007
10.1523/JNEUROSCI.3883-12.2013
10.3389/fnana.2021.801354
10.1101/sqb.2018.83.037648
10.1016/j.neuropharm.2013.03.019
10.1126/sciadv.abm5217
10.1371/journal.pone.0017047
10.1126/sciadv.abc9321
10.1016/j.celrep.2017.06.007
10.1038/nature14855
10.1152/jn.00864.2002
10.1038/s41586-023-06246-7
10.1016/j.cub.2021.09.040
10.1016/j.celrep.2020.01.023
10.1016/j.neuron.2015.08.019
10.1111/j.1460-9568.2007.05604.x
10.1038/s41593-018-0203-4
10.1093/cercor/bhw107
10.1523/JNEUROSCI.0929-19.2019
10.1016/j.neuron.2023.11.002
10.7554/eLife.27689
10.1007/s00429-012-0471-9
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References Soden (CR70) 2020; 23
Mahler (CR62) 2014; 17
Soden, Yee, Zweifel (CR87) 2023; 619
Pribiag (CR29) 2021; 109
Root (CR19) 2012; 66
CR38
Eshel (CR48) 2015; 525
Poulin (CR50) 2018; 21
Tian (CR59) 2016; 91
Bengtson, Osborne (CR30) 2000; 83
CR31
Lerner (CR98) 2015; 162
Root (CR51) 2018; 23
Covelo, Patel, Luviano, Stratford, Wirtshafter (CR12) 2014; 270
Root (CR77) 2020; 32
Lammel, Lim, Malenka (CR53) 2014; 76
Saga, Galineau, Tremblay (CR61) 2022; 16
Pan, Brown, Dudman (CR76) 2013; 16
Omelchenko, Sesack (CR90) 2010; 88
Ahrens, Meyer, Ferguson, Robinson, Aldridge (CR73) 2016; 36
Wang, Tsien (CR91) 2011; 6
Lodge, Grace (CR65) 2011; 29
Tindell, Smith, Pecina, Berridge, Aldridge (CR15) 2006; 96
Pardo-Garcia (CR25) 2019; 39
CR47
Hollon (CR84) 2021; 31
Heinsbroek (CR24) 2017; 37
Lerner, Holloway, Seiler (CR83) 2021; 67
Mohebi (CR75) 2019; 570
Keiflin, Janak (CR82) 2015; 88
Itoga, Berridge, Aldridge (CR8) 2016; 300
Mogenson, Jones, Yim (CR4) 1980; 14
Zahm, Williams, Wohltmann (CR3) 1996; 364
Heimer, Zahm, Churchill, Kalivas, Wohltmann (CR1) 1991; 41
Root, Melendez, Zaborszky, Napier (CR7) 2015; 130
London (CR67) 2018; 38
Cromwell, Berridge (CR13) 1993; 624
Poulin, Gaertner, Moreno-Ramos, Awatramani (CR49) 2020; 43
Ottenheimer (CR60) 2020; 23
Smith, Berridge, Aldridge (CR18) 2011; 108
Bromberg-Martin, Matsumoto, Hikosaka (CR56) 2010; 68
Stratford, Kelley, Simansky (CR11) 1999; 825
Stanford (CR95) 2003; 89
Prasad, McNally (CR22) 2016; 36
Zell (CR46) 2020; 107
Smith, Tindell, Aldridge, Berridge (CR6) 2009; 196
Lutas (CR72) 2019; 22
Schultz, Dayan, Montague (CR81) 1997; 275
Feng (CR36) 2021; 15
Sivaramakrishnan, Lynch (CR94) 2017; 8
Garris (CR86) 1999; 398
de Jong (CR44) 2019; 101
Nieh (CR93) 2016; 90
Faget (CR69) 2016; 15
Watabe-Uchida, Uchida (CR55) 2018; 83
Johnson (CR96) 2008; 586
Kupchik, Prasad (CR40) 2021; 131
Groenewegen, Berendse, Haber (CR2) 1993; 57
Covey, Cheer (CR85) 2019; 27
Yamaguchi, Qi, Wang, Zhang, Morales (CR52) 2015; 41
Richard, Ambroggi, Janak, Fields (CR20) 2016; 90
Stefanik, Kupchik, Brown, Kalivas (CR26) 2013; 33
Al-Hasani (CR43) 2015; 87
Zhu (CR37) 2017; 20
Tindell, Berridge, Aldridge (CR14) 2004; 24
Floresco, West, Ash, Moore, Grace (CR64) 2003; 6
Legaria (CR68) 2022; 25
Ottenheimer (CR21) 2020; 6
Panagis, Miliaressis, Anagnostakis, Spyraki (CR10) 1995; 68
Verharen, Zhu, Lammel (CR54) 2020; 64
CR9
Lammel, Ion, Roeper, Malenka (CR71) 2011; 70
Inbar (CR39) 2020; 40
Heinsbroek (CR41) 2020; 30
Prasad (CR42) 2020; 40
Geisler, Derst, Veh, Zahm (CR32) 2007; 27
Faget (CR33) 2018; 9
McCutcheon, Ebner, Loriaux, Roitman (CR57) 2012; 6
Tooley (CR34) 2018; 83
Cohen, Haesler, Vong, Lowell, Uchida (CR79) 2012; 482
Fiorillo, Song, Yun (CR92) 2013; 33
Prasad, McNally (CR23) 2020; 177
Stephenson-Jones (CR35) 2020; 105
Collins (CR74) 2016; 6
CR97
Yoo (CR45) 2016; 7
Creed, Ntamati, Chandra, Lobo, Luscher (CR28) 2016; 92
Steffensen, Lee, Stobbs, Henriksen (CR80) 2001; 906
Carr, Sesack (CR89) 2000; 20
Kupchik (CR27) 2014; 34
Root, Fabbricatore, Ma, Barker, West (CR17) 2010; 64
Farrell (CR63) 2019; 44
Zhou (CR78) 2022; 8
Nieh (CR88) 2015; 160
Patriarchi (CR58) 2018; 360
Calder (CR5) 2007; 25
Wang (CR66) 2020; 65
Smith, Berridge (CR16) 2005; 25
V Zell (48340_CR46) 2020; 107
W Schultz (48340_CR81) 1997; 275
ME Soden (48340_CR87) 2023; 619
HC Cromwell (48340_CR13) 1993; 624
Y Saga (48340_CR61) 2022; 16
AL Collins (48340_CR74) 2016; 6
DH Root (48340_CR77) 2020; 32
DH Root (48340_CR51) 2018; 23
SC Steffensen (48340_CR80) 2001; 906
L Faget (48340_CR33) 2018; 9
DJ Ottenheimer (48340_CR60) 2020; 23
J Tian (48340_CR59) 2016; 91
JA Heinsbroek (48340_CR24) 2017; 37
KS Smith (48340_CR6) 2009; 196
ME Soden (48340_CR70) 2020; 23
H Pribiag (48340_CR29) 2021; 109
DH Root (48340_CR19) 2012; 66
JM Richard (48340_CR20) 2016; 90
JF Poulin (48340_CR49) 2020; 43
48340_CR31
48340_CR38
F Wang (48340_CR66) 2020; 65
AJ Tindell (48340_CR15) 2006; 96
K Inbar (48340_CR39) 2020; 40
DP Covey (48340_CR85) 2019; 27
M Watabe-Uchida (48340_CR55) 2018; 83
DS Zahm (48340_CR3) 1996; 364
S Sivaramakrishnan (48340_CR94) 2017; 8
N Omelchenko (48340_CR90) 2010; 88
S Lammel (48340_CR71) 2011; 70
HJ Groenewegen (48340_CR2) 1993; 57
R Keiflin (48340_CR82) 2015; 88
48340_CR97
IM Stanford (48340_CR95) 2003; 89
M Stephenson-Jones (48340_CR35) 2020; 105
AA Legaria (48340_CR68) 2022; 25
A Mohebi (48340_CR75) 2019; 570
J Tooley (48340_CR34) 2018; 83
AM Ahrens (48340_CR73) 2016; 36
SB Floresco (48340_CR64) 2003; 6
L Faget (48340_CR69) 2016; 15
EH Nieh (48340_CR93) 2016; 90
IR Covelo (48340_CR12) 2014; 270
EH Nieh (48340_CR88) 2015; 160
MT Stefanik (48340_CR26) 2013; 33
DB Carr (48340_CR89) 2000; 20
YM Kupchik (48340_CR27) 2014; 34
Q Feng (48340_CR36) 2021; 15
NG Hollon (48340_CR84) 2021; 31
AJ Tindell (48340_CR14) 2004; 24
TN Lerner (48340_CR98) 2015; 162
CP Bengtson (48340_CR30) 2000; 83
JH Yoo (48340_CR45) 2016; 7
JF Poulin (48340_CR50) 2018; 21
G Panagis (48340_CR10) 1995; 68
CD Fiorillo (48340_CR92) 2013; 33
L Heimer (48340_CR1) 1991; 41
JY Cohen (48340_CR79) 2012; 482
WL Zhou (48340_CR78) 2022; 8
AA Prasad (48340_CR22) 2016; 36
DH Root (48340_CR17) 2010; 64
T Patriarchi (48340_CR58) 2018; 360
TN Lerner (48340_CR83) 2021; 67
AJ Calder (48340_CR5) 2007; 25
ES Bromberg-Martin (48340_CR56) 2010; 68
S Lammel (48340_CR53) 2014; 76
PA Garris (48340_CR86) 1999; 398
TD London (48340_CR67) 2018; 38
A Lutas (48340_CR72) 2019; 22
DJ Lodge (48340_CR65) 2011; 29
DH Root (48340_CR7) 2015; 130
T Yamaguchi (48340_CR52) 2015; 41
TR Stratford (48340_CR11) 1999; 825
DV Wang (48340_CR91) 2011; 6
48340_CR47
48340_CR9
KS Smith (48340_CR18) 2011; 108
TR Pardo-Garcia (48340_CR25) 2019; 39
JPH Verharen (48340_CR54) 2020; 64
MR Farrell (48340_CR63) 2019; 44
GJ Mogenson (48340_CR4) 1980; 14
SV Mahler (48340_CR62) 2014; 17
AA Prasad (48340_CR42) 2020; 40
M Creed (48340_CR28) 2016; 92
SW Johnson (48340_CR96) 2008; 586
N Eshel (48340_CR48) 2015; 525
WX Pan (48340_CR76) 2013; 16
YM Kupchik (48340_CR40) 2021; 131
S Geisler (48340_CR32) 2007; 27
KS Smith (48340_CR16) 2005; 25
JW de Jong (48340_CR44) 2019; 101
DJ Ottenheimer (48340_CR21) 2020; 6
R Al-Hasani (48340_CR43) 2015; 87
CA Itoga (48340_CR8) 2016; 300
C Zhu (48340_CR37) 2017; 20
JE McCutcheon (48340_CR57) 2012; 6
AA Prasad (48340_CR23) 2020; 177
JA Heinsbroek (48340_CR41) 2020; 30
References_xml – ident: CR97
– volume: 17
  start-page: 577
  year: 2014
  end-page: 585
  ident: CR62
  article-title: Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3664
– volume: 88
  start-page: 981
  year: 2010
  end-page: 991
  ident: CR90
  article-title: Periaqueductal gray afferents synapse onto dopamine and GABA neurons in the rat ventral tegmental area
  publication-title: J. Neurosci. Res
  doi: 10.1002/jnr.22265
– volume: 364
  start-page: 340
  year: 1996
  end-page: 362
  ident: CR3
  article-title: Ventral striatopallidothalamic projection: IV. relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrain
  publication-title: J. Comp. Neurol.
  doi: 10.1002/(SICI)1096-9861(19960108)364:2<340::AID-CNE11>3.0.CO;2-T
– volume: 83
  start-page: 1012
  year: 2018
  end-page: 1023
  ident: CR34
  article-title: Glutamatergic ventral pallidal neurons modulate activity of the Habenula-Tegmental circuitry and constrain reward seeking
  publication-title: Biol. psychiatry
  doi: 10.1016/j.biopsych.2018.01.003
– volume: 15
  start-page: 2796
  year: 2016
  end-page: 2808
  ident: CR69
  article-title: Afferent inputs to neurotransmitter-defined cell types in the ventral tegmental area
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.05.057
– volume: 825
  start-page: 199
  year: 1999
  end-page: 203
  ident: CR11
  article-title: Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(99)01239-1
– volume: 177
  start-page: 3855
  year: 2020
  end-page: 3864
  ident: CR23
  article-title: The ventral pallidum and relapse in alcohol seeking
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.15160
– volume: 40
  start-page: 880
  year: 2020
  end-page: 893
  ident: CR42
  article-title: Complementary roles for ventral pallidum cell types and their projections in relapse
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0262-19.2019
– volume: 27
  start-page: 481
  year: 2019
  end-page: 490.e483
  ident: CR85
  article-title: Accumbal dopamine release tracks the expectation of dopamine neuron-mediated reinforcement
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.03.055
– volume: 24
  start-page: 1058
  year: 2004
  end-page: 1069
  ident: CR14
  article-title: Ventral pallidal representation of pavlovian cues and reward: population and rate codes
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1437-03.2004
– volume: 9
  year: 2018
  ident: CR33
  article-title: Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03125-y
– volume: 33
  start-page: 13654
  year: 2013
  end-page: 13662
  ident: CR26
  article-title: Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1570-13.2013
– volume: 65
  start-page: 389
  year: 2020
  end-page: 401
  ident: CR66
  article-title: Salience processing by glutamatergic neurons in the ventral pallidum
  publication-title: Sci. Bull. (Beijing)
  doi: 10.1016/j.scib.2019.11.029
– volume: 20
  start-page: 3864
  year: 2000
  end-page: 3873
  ident: CR89
  article-title: Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-10-03864.2000
– volume: 482
  start-page: 85
  year: 2012
  end-page: 88
  ident: CR79
  article-title: Neuron-type-specific signals for reward and punishment in the ventral tegmental area
  publication-title: Nature
  doi: 10.1038/nature10754
– volume: 586
  start-page: 2033
  year: 2008
  ident: CR96
  article-title: Rebound bursts following inhibition: how dopamine modifies firing pattern in subthalamic neurons
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2008.153643
– volume: 96
  start-page: 2399
  year: 2006
  end-page: 2409
  ident: CR15
  article-title: Ventral pallidum firing codes hedonic reward: when a bad taste turns good
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00576.2006
– volume: 57
  start-page: 113
  year: 1993
  end-page: 142
  ident: CR2
  article-title: Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(93)90115-V
– volume: 41
  start-page: 760
  year: 2015
  end-page: 772
  ident: CR52
  article-title: Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/ejn.12818
– volume: 300
  start-page: 175
  year: 2016
  end-page: 183
  ident: CR8
  article-title: Ventral pallidal coding of a learned taste aversion
  publication-title: Behav. Brain Res
  doi: 10.1016/j.bbr.2015.11.024
– volume: 32
  year: 2020
  ident: CR77
  article-title: Distinct signaling by ventral tegmental area glutamate, GABA, and combinatorial glutamate-GABA Neurons in motivated behavior
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108094
– volume: 360
  start-page: eaat4422
  year: 2018
  ident: CR58
  article-title: Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
  publication-title: Science
  doi: 10.1126/science.aat4422
– volume: 14
  start-page: 69
  year: 1980
  end-page: 97
  ident: CR4
  article-title: From motivation to action: functional interface between the limbic system and the motor system
  publication-title: Prog. Neurobiol.
  doi: 10.1016/0301-0082(80)90018-0
– volume: 68
  start-page: 165
  year: 1995
  end-page: 172
  ident: CR10
  article-title: Ventral pallidum self-stimulation: a moveable electrode mapping study
  publication-title: Behav. Brain Res
  doi: 10.1016/0166-4328(94)00169-G
– volume: 34
  start-page: 1057
  year: 2014
  end-page: 1066
  ident: CR27
  article-title: Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4336-13.2014
– volume: 275
  start-page: 1593
  year: 1997
  end-page: 1599
  ident: CR81
  article-title: A neural substrate of prediction and reward
  publication-title: Science
  doi: 10.1126/science.275.5306.1593
– volume: 6
  year: 2016
  ident: CR74
  article-title: Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation
  publication-title: Sci. Rep.
  doi: 10.1038/srep20231
– ident: CR47
– volume: 196
  start-page: 155
  year: 2009
  end-page: 167
  ident: CR6
  article-title: Ventral pallidum roles in reward and motivation
  publication-title: Behav. Brain Res
  doi: 10.1016/j.bbr.2008.09.038
– volume: 64
  start-page: 46
  year: 2020
  end-page: 52
  ident: CR54
  article-title: Aversion hot spots in the dopamine system
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2020.02.002
– volume: 43
  start-page: 155
  year: 2020
  end-page: 169
  ident: CR49
  article-title: Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2020.01.004
– volume: 22
  start-page: 1820
  year: 2019
  end-page: 1833
  ident: CR72
  article-title: State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-019-0506-0
– volume: 39
  start-page: 2041
  year: 2019
  end-page: 2051
  ident: CR25
  article-title: Ventral pallidum is the primary target for accumbens D1 projections driving cocaine seeking
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2822-18.2018
– volume: 6
  start-page: 137
  year: 2012
  ident: CR57
  article-title: Encoding of aversion by dopamine and the nucleus accumbens
  publication-title: Front Neurosci.
  doi: 10.3389/fnins.2012.00137
– volume: 37
  start-page: 757
  year: 2017
  end-page: 767
  ident: CR24
  article-title: Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2659-16.2016
– volume: 109
  start-page: 2165
  year: 2021
  end-page: 2182.e2110
  ident: CR29
  article-title: Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking
  publication-title: Neuron
  doi: 10.1016/j.neuron.2021.05.002
– volume: 624
  start-page: 1
  year: 1993
  end-page: 10
  ident: CR13
  article-title: Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?
  publication-title: Brain Res
  doi: 10.1016/0006-8993(93)90053-P
– ident: CR38
– volume: 38
  start-page: 3547
  year: 2018
  end-page: 3558
  ident: CR67
  article-title: Coordinated ramping of dorsal striatal pathways preceding food approach and consumption
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2693-17.2018
– volume: 29
  start-page: 207
  year: 2011
  end-page: 213
  ident: CR65
  article-title: Developmental pathology, dopamine, stress and schizophrenia
  publication-title: Int J. Dev. Neurosci.
  doi: 10.1016/j.ijdevneu.2010.08.002
– volume: 66
  start-page: 106
  year: 2012
  end-page: 127
  ident: CR19
  article-title: Slow phasic and tonic activity of ventral pallidal neurons during cocaine self-administration
  publication-title: Synapse
  doi: 10.1002/syn.20990
– volume: 83
  start-page: 2649
  year: 2000
  end-page: 2660
  ident: CR30
  article-title: Electrophysiological properties of cholinergic and noncholinergic neurons in the ventral pallidal region of the nucleus basalis in rat brain slices
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.2000.83.5.2649
– volume: 107
  start-page: 864
  year: 2020
  end-page: 873
  ident: CR46
  article-title: VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release
  publication-title: Neuron
  doi: 10.1016/j.neuron.2020.06.011
– volume: 68
  start-page: 815
  year: 2010
  end-page: 834
  ident: CR56
  article-title: Dopamine in motivational control: rewarding, aversive, and alerting
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.11.022
– volume: 90
  start-page: 1286
  year: 2016
  end-page: 1298
  ident: CR93
  article-title: Inhibitory input from the lateral hypothalamus to the ventral tegmental area disinhibits dopamine neurons and promotes behavioral activation
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.035
– volume: 36
  start-page: 11716
  year: 2016
  end-page: 11726
  ident: CR22
  article-title: Ventral pallidum output pathways in context-induced reinstatement of alcohol seeking
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2580-16.2016
– volume: 8
  start-page: 492
  year: 2017
  ident: CR94
  article-title: Rebound from Inhibition: self-correction against Neurodegeneration?
  publication-title: J. Clin. Cell Immunol.
  doi: 10.4172/2155-9899.1000492
– volume: 25
  start-page: 8637
  year: 2005
  end-page: 8649
  ident: CR16
  article-title: The ventral pallidum and hedonic reward: neurochemical maps of sucrose “liking” and food intake
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1902-05.2005
– volume: 570
  start-page: 65
  year: 2019
  end-page: 70
  ident: CR75
  article-title: Dissociable dopamine dynamics for learning and motivation
  publication-title: Nature
  doi: 10.1038/s41586-019-1235-y
– volume: 36
  start-page: 7957
  year: 2016
  end-page: 7970
  ident: CR73
  article-title: Neural activity in the ventral pallidum encodes variation in the incentive value of a reward cue
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0736-16.2016
– volume: 398
  start-page: 67
  year: 1999
  end-page: 69
  ident: CR86
  article-title: Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
  publication-title: Nature
  doi: 10.1038/18019
– volume: 44
  start-page: 2174
  year: 2019
  end-page: 2185
  ident: CR63
  article-title: Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats
  publication-title: Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol.
  doi: 10.1038/s41386-019-0507-4
– volume: 160
  start-page: 528
  year: 2015
  end-page: 541
  ident: CR88
  article-title: Decoding neural circuits that control compulsive sucrose seeking
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.003
– volume: 67
  start-page: 123
  year: 2021
  end-page: 130
  ident: CR83
  article-title: Dopamine, updated: reward prediction error and beyond
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2020.10.012
– volume: 16
  start-page: 1009626
  year: 2022
  ident: CR61
  article-title: Impulsive and compulsive behaviors can be induced by opposite GABAergic dysfunctions inside the primate ventral pallidum
  publication-title: Front Syst. Neurosci.
  doi: 10.3389/fnsys.2022.1009626
– volume: 6
  start-page: 968
  year: 2003
  end-page: 973
  ident: CR64
  article-title: Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1103
– volume: 88
  start-page: 247
  year: 2015
  end-page: 263
  ident: CR82
  article-title: Dopamine prediction errors in reward learning and addiction: from theory to neural circuitry
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.08.037
– volume: 105
  start-page: 921
  year: 2020
  end-page: 933.e5
  ident: CR35
  article-title: Opposing contributions of GABAergic and glutamatergic ventral pallidal neurons to motivational behaviors
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.12.006
– volume: 27
  start-page: 5730
  year: 2007
  end-page: 5743
  ident: CR32
  article-title: Glutamatergic afferents of the ventral tegmental area in the rat
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0012-07.2007
– ident: CR9
– volume: 92
  start-page: 214
  year: 2016
  end-page: 226
  ident: CR28
  article-title: Convergence of reinforcing and anhedonic cocaine effects in the ventral pallidum
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.09.001
– volume: 25
  start-page: 1124
  year: 2022
  end-page: 1128
  ident: CR68
  article-title: Fiber photometry in striatum reflects primarily nonsomatic changes in calcium
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-022-01152-z
– volume: 162
  start-page: 635
  year: 2015
  end-page: 647
  ident: CR98
  article-title: Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.014
– volume: 41
  start-page: 89
  year: 1991
  end-page: 125
  ident: CR1
  article-title: Specificity in the projection patterns of accumbal core and shell in the rat
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(91)90202-Y
– volume: 64
  start-page: 704
  year: 2010
  end-page: 713
  ident: CR17
  article-title: Rapid phasic activity of ventral pallidal neurons during cocaine self-administration
  publication-title: Synapse
  doi: 10.1002/syn.20792
– volume: 108
  start-page: E255
  year: 2011
  end-page: E264
  ident: CR18
  article-title: Disentangling pleasure from incentive salience and learning signals in brain reward circuitry
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1101920108
– volume: 7
  year: 2016
  ident: CR45
  article-title: Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13697
– volume: 91
  start-page: 1374
  year: 2016
  end-page: 1389
  ident: CR59
  article-title: Distributed and mixed information in monosynaptic inputs to dopamine neurons
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.08.018
– volume: 23
  start-page: 1267
  year: 2020
  end-page: 1276
  ident: CR60
  article-title: A quantitative reward prediction error signal in the ventral pallidum
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0688-5
– volume: 130
  start-page: 29
  year: 2015
  end-page: 70
  ident: CR7
  article-title: The ventral pallidum: subregion-specific functional anatomy and roles in motivated behaviors
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2015.03.005
– volume: 90
  start-page: 1165
  year: 2016
  end-page: 1173
  ident: CR20
  article-title: Ventral pallidum neurons encode incentive value and promote cue-elicited instrumental actions
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.037
– volume: 40
  start-page: 1321
  year: 2020
  end-page: 1331
  ident: CR39
  article-title: Cocaine dysregulates dynorphin modulation of inhibitory neurotransmission in the ventral pallidum in a cell-type-specific manner
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1262-19.2019
– volume: 70
  start-page: 855
  year: 2011
  end-page: 862
  ident: CR71
  article-title: Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.03.025
– volume: 101
  start-page: 133
  year: 2019
  end-page: 151
  ident: CR44
  article-title: A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.11.005
– volume: 23
  start-page: 968
  year: 2020
  end-page: 980
  ident: CR70
  article-title: Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0657-z
– volume: 906
  start-page: 190
  year: 2001
  end-page: 197
  ident: CR80
  article-title: Responses of ventral tegmental area GABA neurons to brain stimulation reward
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(01)02581-1
– volume: 23
  start-page: 3465
  year: 2018
  end-page: 3479
  ident: CR51
  article-title: Selective brain distribution and distinctive synaptic architecture of dual glutamatergic-GABAergic Neurons
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.05.063
– volume: 16
  start-page: 71
  year: 2013
  end-page: 78
  ident: CR76
  article-title: Neural signals of extinction in the inhibitory microcircuit of the ventral midbrain
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3283
– volume: 270
  start-page: 316
  year: 2014
  end-page: 325
  ident: CR12
  article-title: Manipulation of GABA in the ventral pallidum, but not the nucleus accumbens, induces intense, preferential, fat consumption in rats
  publication-title: Behav. Brain Res
  doi: 10.1016/j.bbr.2014.05.032
– volume: 131
  start-page: 373
  year: 2021
  end-page: 386
  ident: CR40
  article-title: Ventral pallidum cellular and pathway specificity in drug seeking
  publication-title: Neurosci. Biobehav Rev.
  doi: 10.1016/j.neubiorev.2021.09.007
– volume: 33
  start-page: 4710
  year: 2013
  end-page: 4725
  ident: CR92
  article-title: Multiphasic temporal dynamics in responses of midbrain dopamine neurons to appetitive and aversive stimuli
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3883-12.2013
– volume: 15
  year: 2021
  ident: CR36
  article-title: Whole-brain reconstruction of neurons in the ventral pallidum reveals diverse projection patterns
  publication-title: Front Neuroanat.
  doi: 10.3389/fnana.2021.801354
– volume: 83
  start-page: 83
  year: 2018
  end-page: 95
  ident: CR55
  article-title: Multiple dopamine systems: weal and woe of dopamine
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/sqb.2018.83.037648
– volume: 76
  start-page: 351
  year: 2014
  end-page: 359
  ident: CR53
  article-title: Reward and aversion in a heterogeneous midbrain dopamine system
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2013.03.019
– ident: CR31
– volume: 8
  year: 2022
  ident: CR78
  article-title: Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abm5217
– volume: 6
  start-page: e17047
  year: 2011
  ident: CR91
  article-title: Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0017047
– volume: 6
  start-page: eabc9321
  year: 2020
  ident: CR21
  article-title: Reward activity in ventral pallidum tracks satiety-sensitive preference and drives choice behavior
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc9321
– volume: 20
  start-page: 112
  year: 2017
  end-page: 123
  ident: CR37
  article-title: Somatostatin neurons in the basal forebrain promote high-calorie food intake
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.06.007
– volume: 525
  start-page: 243
  year: 2015
  end-page: 246
  ident: CR48
  article-title: Arithmetic and local circuitry underlying dopamine prediction errors
  publication-title: Nature
  doi: 10.1038/nature14855
– volume: 89
  start-page: 1713
  year: 2003
  end-page: 1717
  ident: CR95
  article-title: Independent neuronal oscillators of the rat globus pallidus
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00864.2002
– volume: 619
  start-page: 332
  year: 2023
  end-page: 337
  ident: CR87
  article-title: Circuit coordination of opposing neuropeptide and neurotransmitter signals
  publication-title: Nature
  doi: 10.1038/s41586-023-06246-7
– volume: 31
  start-page: 5350
  year: 2021
  end-page: 5363.e5355
  ident: CR84
  article-title: Nigrostriatal dopamine signals sequence-specific action-outcome prediction errors
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2021.09.040
– volume: 30
  start-page: 2018
  year: 2020
  end-page: 2027.e2013
  ident: CR41
  article-title: Opposing regulation of cocaine seeking by glutamate and GABA neurons in the ventral pallidum
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.01.023
– volume: 87
  start-page: 1063
  year: 2015
  end-page: 1077
  ident: CR43
  article-title: Distinct subpopulations of nucleus accumbens dynorphin neurons drive aversion and reward
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.08.019
– volume: 25
  start-page: 3422
  year: 2007
  end-page: 3428
  ident: CR5
  article-title: Disgust sensitivity predicts the insula and pallidal response to pictures of disgusting foods
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2007.05604.x
– volume: 21
  start-page: 1260
  year: 2018
  end-page: 1271
  ident: CR50
  article-title: Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0203-4
– volume: 41
  start-page: 89
  year: 1991
  ident: 48340_CR1
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(91)90202-Y
– volume: 14
  start-page: 69
  year: 1980
  ident: 48340_CR4
  publication-title: Prog. Neurobiol.
  doi: 10.1016/0301-0082(80)90018-0
– volume: 43
  start-page: 155
  year: 2020
  ident: 48340_CR49
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2020.01.004
– volume: 619
  start-page: 332
  year: 2023
  ident: 48340_CR87
  publication-title: Nature
  doi: 10.1038/s41586-023-06246-7
– volume: 8
  start-page: 492
  year: 2017
  ident: 48340_CR94
  publication-title: J. Clin. Cell Immunol.
  doi: 10.4172/2155-9899.1000492
– volume: 17
  start-page: 577
  year: 2014
  ident: 48340_CR62
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3664
– volume: 162
  start-page: 635
  year: 2015
  ident: 48340_CR98
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.014
– volume: 65
  start-page: 389
  year: 2020
  ident: 48340_CR66
  publication-title: Sci. Bull. (Beijing)
  doi: 10.1016/j.scib.2019.11.029
– volume: 30
  start-page: 2018
  year: 2020
  ident: 48340_CR41
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.01.023
– volume: 83
  start-page: 2649
  year: 2000
  ident: 48340_CR30
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.2000.83.5.2649
– volume: 108
  start-page: E255
  year: 2011
  ident: 48340_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1101920108
– volume: 70
  start-page: 855
  year: 2011
  ident: 48340_CR71
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.03.025
– volume: 34
  start-page: 1057
  year: 2014
  ident: 48340_CR27
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4336-13.2014
– volume: 20
  start-page: 112
  year: 2017
  ident: 48340_CR37
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.06.007
– volume: 32
  year: 2020
  ident: 48340_CR77
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108094
– volume: 36
  start-page: 11716
  year: 2016
  ident: 48340_CR22
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2580-16.2016
– ident: 48340_CR9
  doi: 10.1093/cercor/bhw107
– volume: 131
  start-page: 373
  year: 2021
  ident: 48340_CR40
  publication-title: Neurosci. Biobehav Rev.
  doi: 10.1016/j.neubiorev.2021.09.007
– volume: 101
  start-page: 133
  year: 2019
  ident: 48340_CR44
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.11.005
– volume: 482
  start-page: 85
  year: 2012
  ident: 48340_CR79
  publication-title: Nature
  doi: 10.1038/nature10754
– volume: 300
  start-page: 175
  year: 2016
  ident: 48340_CR8
  publication-title: Behav. Brain Res
  doi: 10.1016/j.bbr.2015.11.024
– volume: 360
  start-page: eaat4422
  year: 2018
  ident: 48340_CR58
  publication-title: Science
  doi: 10.1126/science.aat4422
– volume: 270
  start-page: 316
  year: 2014
  ident: 48340_CR12
  publication-title: Behav. Brain Res
  doi: 10.1016/j.bbr.2014.05.032
– volume: 525
  start-page: 243
  year: 2015
  ident: 48340_CR48
  publication-title: Nature
  doi: 10.1038/nature14855
– volume: 40
  start-page: 880
  year: 2020
  ident: 48340_CR42
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0262-19.2019
– volume: 109
  start-page: 2165
  year: 2021
  ident: 48340_CR29
  publication-title: Neuron
  doi: 10.1016/j.neuron.2021.05.002
– volume: 96
  start-page: 2399
  year: 2006
  ident: 48340_CR15
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00576.2006
– volume: 6
  start-page: eabc9321
  year: 2020
  ident: 48340_CR21
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc9321
– volume: 570
  start-page: 65
  year: 2019
  ident: 48340_CR75
  publication-title: Nature
  doi: 10.1038/s41586-019-1235-y
– volume: 196
  start-page: 155
  year: 2009
  ident: 48340_CR6
  publication-title: Behav. Brain Res
  doi: 10.1016/j.bbr.2008.09.038
– volume: 83
  start-page: 83
  year: 2018
  ident: 48340_CR55
  publication-title: Cold Spring Harb. Symp. Quant. Biol.
  doi: 10.1101/sqb.2018.83.037648
– volume: 83
  start-page: 1012
  year: 2018
  ident: 48340_CR34
  publication-title: Biol. psychiatry
  doi: 10.1016/j.biopsych.2018.01.003
– volume: 25
  start-page: 1124
  year: 2022
  ident: 48340_CR68
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-022-01152-z
– volume: 67
  start-page: 123
  year: 2021
  ident: 48340_CR83
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2020.10.012
– volume: 57
  start-page: 113
  year: 1993
  ident: 48340_CR2
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(93)90115-V
– volume: 825
  start-page: 199
  year: 1999
  ident: 48340_CR11
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(99)01239-1
– volume: 6
  start-page: e17047
  year: 2011
  ident: 48340_CR91
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0017047
– volume: 40
  start-page: 1321
  year: 2020
  ident: 48340_CR39
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1262-19.2019
– volume: 22
  start-page: 1820
  year: 2019
  ident: 48340_CR72
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-019-0506-0
– volume: 37
  start-page: 757
  year: 2017
  ident: 48340_CR24
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2659-16.2016
– volume: 89
  start-page: 1713
  year: 2003
  ident: 48340_CR95
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00864.2002
– volume: 6
  start-page: 137
  year: 2012
  ident: 48340_CR57
  publication-title: Front Neurosci.
  doi: 10.3389/fnins.2012.00137
– volume: 44
  start-page: 2174
  year: 2019
  ident: 48340_CR63
  publication-title: Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol.
  doi: 10.1038/s41386-019-0507-4
– volume: 16
  start-page: 1009626
  year: 2022
  ident: 48340_CR61
  publication-title: Front Syst. Neurosci.
  doi: 10.3389/fnsys.2022.1009626
– volume: 64
  start-page: 46
  year: 2020
  ident: 48340_CR54
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2020.02.002
– volume: 23
  start-page: 1267
  year: 2020
  ident: 48340_CR60
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0688-5
– volume: 27
  start-page: 5730
  year: 2007
  ident: 48340_CR32
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0012-07.2007
– volume: 25
  start-page: 8637
  year: 2005
  ident: 48340_CR16
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1902-05.2005
– volume: 130
  start-page: 29
  year: 2015
  ident: 48340_CR7
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2015.03.005
– volume: 15
  start-page: 2796
  year: 2016
  ident: 48340_CR69
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.05.057
– volume: 29
  start-page: 207
  year: 2011
  ident: 48340_CR65
  publication-title: Int J. Dev. Neurosci.
  doi: 10.1016/j.ijdevneu.2010.08.002
– volume: 41
  start-page: 760
  year: 2015
  ident: 48340_CR52
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/ejn.12818
– volume: 20
  start-page: 3864
  year: 2000
  ident: 48340_CR89
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-10-03864.2000
– volume: 76
  start-page: 351
  year: 2014
  ident: 48340_CR53
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2013.03.019
– volume: 68
  start-page: 815
  year: 2010
  ident: 48340_CR56
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.11.022
– volume: 105
  start-page: 921
  year: 2020
  ident: 48340_CR35
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.12.006
– volume: 23
  start-page: 968
  year: 2020
  ident: 48340_CR70
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0657-z
– volume: 586
  start-page: 2033
  year: 2008
  ident: 48340_CR96
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2008.153643
– volume: 107
  start-page: 864
  year: 2020
  ident: 48340_CR46
  publication-title: Neuron
  doi: 10.1016/j.neuron.2020.06.011
– volume: 87
  start-page: 1063
  year: 2015
  ident: 48340_CR43
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.08.019
– volume: 8
  year: 2022
  ident: 48340_CR78
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abm5217
– volume: 92
  start-page: 214
  year: 2016
  ident: 48340_CR28
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.09.001
– volume: 36
  start-page: 7957
  year: 2016
  ident: 48340_CR73
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0736-16.2016
– volume: 31
  start-page: 5350
  year: 2021
  ident: 48340_CR84
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2021.09.040
– ident: 48340_CR38
  doi: 10.1523/JNEUROSCI.0929-19.2019
– volume: 66
  start-page: 106
  year: 2012
  ident: 48340_CR19
  publication-title: Synapse
  doi: 10.1002/syn.20990
– volume: 25
  start-page: 3422
  year: 2007
  ident: 48340_CR5
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2007.05604.x
– volume: 21
  start-page: 1260
  year: 2018
  ident: 48340_CR50
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0203-4
– volume: 906
  start-page: 190
  year: 2001
  ident: 48340_CR80
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(01)02581-1
– volume: 90
  start-page: 1286
  year: 2016
  ident: 48340_CR93
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.035
– volume: 38
  start-page: 3547
  year: 2018
  ident: 48340_CR67
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2693-17.2018
– volume: 624
  start-page: 1
  year: 1993
  ident: 48340_CR13
  publication-title: Brain Res
  doi: 10.1016/0006-8993(93)90053-P
– ident: 48340_CR47
  doi: 10.1016/j.neuron.2023.11.002
– volume: 68
  start-page: 165
  year: 1995
  ident: 48340_CR10
  publication-title: Behav. Brain Res
  doi: 10.1016/0166-4328(94)00169-G
– volume: 24
  start-page: 1058
  year: 2004
  ident: 48340_CR14
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1437-03.2004
– volume: 33
  start-page: 13654
  year: 2013
  ident: 48340_CR26
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1570-13.2013
– volume: 15
  year: 2021
  ident: 48340_CR36
  publication-title: Front Neuroanat.
  doi: 10.3389/fnana.2021.801354
– volume: 7
  year: 2016
  ident: 48340_CR45
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13697
– volume: 23
  start-page: 3465
  year: 2018
  ident: 48340_CR51
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.05.063
– volume: 91
  start-page: 1374
  year: 2016
  ident: 48340_CR59
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.08.018
– volume: 177
  start-page: 3855
  year: 2020
  ident: 48340_CR23
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.15160
– volume: 64
  start-page: 704
  year: 2010
  ident: 48340_CR17
  publication-title: Synapse
  doi: 10.1002/syn.20792
– volume: 275
  start-page: 1593
  year: 1997
  ident: 48340_CR81
  publication-title: Science
  doi: 10.1126/science.275.5306.1593
– volume: 160
  start-page: 528
  year: 2015
  ident: 48340_CR88
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.003
– volume: 39
  start-page: 2041
  year: 2019
  ident: 48340_CR25
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2822-18.2018
– volume: 88
  start-page: 981
  year: 2010
  ident: 48340_CR90
  publication-title: J. Neurosci. Res
  doi: 10.1002/jnr.22265
– volume: 33
  start-page: 4710
  year: 2013
  ident: 48340_CR92
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3883-12.2013
– volume: 6
  start-page: 968
  year: 2003
  ident: 48340_CR64
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1103
– ident: 48340_CR97
  doi: 10.7554/eLife.27689
– volume: 398
  start-page: 67
  year: 1999
  ident: 48340_CR86
  publication-title: Nature
  doi: 10.1038/18019
– ident: 48340_CR31
  doi: 10.1007/s00429-012-0471-9
– volume: 6
  year: 2016
  ident: 48340_CR74
  publication-title: Sci. Rep.
  doi: 10.1038/srep20231
– volume: 88
  start-page: 247
  year: 2015
  ident: 48340_CR82
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.08.037
– volume: 27
  start-page: 481
  year: 2019
  ident: 48340_CR85
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.03.055
– volume: 364
  start-page: 340
  year: 1996
  ident: 48340_CR3
  publication-title: J. Comp. Neurol.
  doi: 10.1002/(SICI)1096-9861(19960108)364:2<340::AID-CNE11>3.0.CO;2-T
– volume: 9
  year: 2018
  ident: 48340_CR33
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03125-y
– volume: 90
  start-page: 1165
  year: 2016
  ident: 48340_CR20
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.037
– volume: 16
  start-page: 71
  year: 2013
  ident: 48340_CR76
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3283
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Snippet The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance,...
Abstract The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and...
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SubjectTerms 631/378/1662
631/378/1788
631/378/3920
64/60
82/1
82/51
96/10
96/35
96/44
96/63
Animals
Aversion
Avoidance
Avoidance behavior
Avoidance Learning - physiology
Basal Forebrain - metabolism
Basal Forebrain - physiology
Behavior, Animal - physiology
Dopamine
Dopamine - metabolism
Dopaminergic Neurons - metabolism
Dopaminergic Neurons - physiology
GABAergic Neurons - metabolism
GABAergic Neurons - physiology
gamma-Aminobutyric Acid - metabolism
Globus pallidus
Glutamic Acid - metabolism
Humanities and Social Sciences
Hypothalamus (ventromedial)
Male
Mice
Mice, Inbred C57BL
multidisciplinary
Neurons
Neurons - metabolism
Neurons - physiology
Nucleus accumbens
Nucleus Accumbens - cytology
Nucleus Accumbens - metabolism
Nucleus Accumbens - physiology
Pallidum (ventral)
Reinforcement
Reward
Science
Science (multidisciplinary)
Stimulation
Ventral Tegmental Area - cytology
Ventral Tegmental Area - metabolism
Ventral Tegmental Area - physiology
Ventral tegmentum
γ-Aminobutyric acid
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Title Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types
URI https://link.springer.com/article/10.1038/s41467-024-48340-y
https://www.ncbi.nlm.nih.gov/pubmed/38762463
https://www.proquest.com/docview/3056251076
https://www.proquest.com/docview/3056664714
https://pubmed.ncbi.nlm.nih.gov/PMC11102457
https://doaj.org/article/3c4fcbceb33e4310812002dd0d5f997a
Volume 15
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