Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease

• Published in: Scientific reports Vol. 13; no. 1; pp. 13068 - 9
• Main Authors: Li, Dezhao, Dun, Yaoshan, Qi, Dake, Ripley-Gonzalez, Jeffrey W., Dong, Jie, Zhou, Nanjiang, Qiu, Ling, Zhang, Jie, Zeng, Tanghao, You, Baiyang, Liu, Suixin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/319/1488/393; 692/163/2743/393; Animals; Apoptosis; Autophagy; Blood; Body weight; Diet; Diet, High-Fat - adverse effects; Fasting; Fatty liver; High fat diet; Humanities and Social Sciences; Intermittent Fasting; Leukocyte migration; Lipid Metabolism; Lipids; Liver; Liver - metabolism; Liver diseases; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - metabolism; Metabolic disorders; Mice; Mice, Inbred C57BL; multidisciplinary; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - therapy; Science; Science (multidisciplinary)

Switching to normal diet (ND) is the regular therapy for high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD). Intermittent fasting (IF) is a unique treatment which may exhibits better therapeutic efficacy. Thus, we aim to investigate the therapeutic effects of these treatments and e...