FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA

• Published in: Cancer medicine (Malden, MA) Vol. 13; no. 24; pp. e70507 - n/a
• Main Authors: Chen, Bingxin, Wang, Liming, Li, Xiaomin, Ren, Ci, Gao, Chun, Ding, Wencheng, Wang, Hui
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2024; John Wiley and Sons Inc; Wiley
• Subjects: Adenosine - analogs & derivatives; Adenosine - metabolism; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism; Animals; Antibodies; Body fat; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Cells; Cervical cancer; cervical carcinoma; Cloning; Demethylation; Epigenetics; Ethanol; Female; Females; Fluorides; Forkhead protein; FTO; Gene expression; Gene Expression Regulation, Neoplastic; Human papillomavirus; Humans; Kinases; Lymphatic system; m6A; Malignancy; Metastases; Metastasis; Mice; Mice, Nude; N6-methyladenosine; PIK3R3; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transcriptomes; Transfection; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; FTO; PIK3R3; m6A; malignancy; cervical carcinoma

ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. Aims Our study aimed to narr...