FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA

ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. Aims Our study aimed to narr...

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Published inCancer medicine (Malden, MA) Vol. 13; no. 24; pp. e70507 - n/a
Main Authors Chen, Bingxin, Wang, Liming, Li, Xiaomin, Ren, Ci, Gao, Chun, Ding, Wencheng, Wang, Hui
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.12.2024
John Wiley and Sons Inc
Wiley
Subjects
Adenosine - analogs & derivatives
Adenosine - metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism
Animals
Antibodies
Body fat
Cell Line, Tumor
Cell migration
Cell Movement
Cell Proliferation
Cells
Cervical cancer
cervical carcinoma
Cloning
Demethylation
Epigenetics
Ethanol
Female
Females
Fluorides
Forkhead protein
FTO
Gene expression
Gene Expression Regulation, Neoplastic
Human papillomavirus
Humans
Kinases
Lymphatic system
m6A
Malignancy
Metastases
Metastasis
Mice
Mice, Nude
N6-methyladenosine
PIK3R3
Proteins
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcriptomes
Transfection
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
FTO
PIK3R3
m6A
malignancy
cervical carcinoma
Online AccessGet full text

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Abstract ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. Aims Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy. Materials & Methods We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip‐seq and Merip‐qPCR are used to profile m6A transcriptome‐wide. Finally, western blot were performed to identify the regulatory mechanism. Results Based on TCGA‐CESC cohort and GEO dataset, FTO expression levels in HPV‐positive cancer patients were significantly higher than those in HPV‐negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip‐seq and Merip‐qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer. Conclusion All in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
AbstractList ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. Aims Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy. Materials & Methods We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip‐seq and Merip‐qPCR are used to profile m6A transcriptome‐wide. Finally, western blot were performed to identify the regulatory mechanism. Results Based on TCGA‐CESC cohort and GEO dataset, FTO expression levels in HPV‐positive cancer patients were significantly higher than those in HPV‐negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip‐seq and Merip‐qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer. Conclusion All in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6-methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity-associated gene (FTO) works as the m6A demethylase. Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy. We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip-seq and Merip-qPCR are used to profile m6A transcriptome-wide. Finally, western blot were performed to identify the regulatory mechanism. Based on TCGA-CESC cohort and GEO dataset, FTO expression levels in HPV-positive cancer patients were significantly higher than those in HPV-negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip-seq and Merip-qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer. All in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. Aims Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy. Materials & Methods We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip‐seq and Merip‐qPCR are used to profile m6A transcriptome‐wide. Finally, western blot were performed to identify the regulatory mechanism. Results Based on TCGA‐CESC cohort and GEO dataset, FTO expression levels in HPV‐positive cancer patients were significantly higher than those in HPV‐negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip‐seq and Merip‐qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer. Conclusion All in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6-methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity-associated gene (FTO) works as the m6A demethylase.BACKGROUNDThe incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6-methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity-associated gene (FTO) works as the m6A demethylase.Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy.AIMSOur study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy.We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip-seq and Merip-qPCR are used to profile m6A transcriptome-wide. Finally, western blot were performed to identify the regulatory mechanism.MATERIALS & METHODSWe analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip-seq and Merip-qPCR are used to profile m6A transcriptome-wide. Finally, western blot were performed to identify the regulatory mechanism.Based on TCGA-CESC cohort and GEO dataset, FTO expression levels in HPV-positive cancer patients were significantly higher than those in HPV-negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip-seq and Merip-qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer.RESULTSBased on TCGA-CESC cohort and GEO dataset, FTO expression levels in HPV-positive cancer patients were significantly higher than those in HPV-negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip-seq and Merip-qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer.All in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.CONCLUSIONAll in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. Aims Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy. Materials & Methods We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip‐seq and Merip‐qPCR are used to profile m6A transcriptome‐wide. Finally, western blot were performed to identify the regulatory mechanism. Results Based on TCGA‐CESC cohort and GEO dataset, FTO expression levels in HPV‐positive cancer patients were significantly higher than those in HPV‐negative cancer patients and could predict advanced FIGO stage. The protein level of FTO in cervical cancerous tissue was higher than that in paracancerous tissue. Functional assays indicated that FTO promoted the proliferation, migration and invasion of cervical cancer cells both in vitro and in vivo. The Merip‐seq and Merip‐qPCR evoked that relative PIK3R3 m6A level was significantly increased after FTO knockdown, which effected the activation of FoxO pathway. After knocking down FTO, upregulation of PIK3R3 can restore the malignancy of cervical cancer. Conclusion All in all, these data suggest a vital role for FTO in occurrence and development of cervical cancer.
Author Chen, Bingxin
Wang, Hui
Ding, Wencheng
Li, Xiaomin
Wang, Liming
Ren, Ci
Gao, Chun
AuthorAffiliation 1 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China
2 Department of Gynecologic Oncology, Women's Hospital Zhejiang University School of Medicine Hangzhou China
AuthorAffiliation_xml – name: 2 Department of Gynecologic Oncology, Women's Hospital Zhejiang University School of Medicine Hangzhou China
– name: 1 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China
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  fullname: Chen, Bingxin
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  fullname: Wang, Liming
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  surname: Li
  fullname: Li, Xiaomin
  organization: Huazhong University of Science and Technology
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  fullname: Ren, Ci
  organization: Huazhong University of Science and Technology
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  organization: Zhejiang University School of Medicine
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Issue 24
Keywords FTO
PIK3R3
m6A
malignancy
cervical carcinoma
Language English
License Attribution
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This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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This study was funded by grants from the National Natural Science Foundation of China (81830074) and the Natural Science Foundation of Zhejiang Province (No. LQ23H160033).
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Funding: This study was funded by grants from the National Natural Science Foundation of China (81830074) and the Natural Science Foundation of Zhejiang Province (No. LQ23H160033).
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Snippet ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an...
The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6-methyladenosine (m6A) always plays an important role in...
ABSTRACT Background The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6‐methyladenosine (m6A) always plays an...
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pubmedcentral
proquest
pubmed
crossref
wiley
SourceType Open Website
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StartPage e70507
SubjectTerms Adenosine - analogs & derivatives
Adenosine - metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism
Animals
Antibodies
Body fat
Cell Line, Tumor
Cell migration
Cell Movement
Cell Proliferation
Cells
Cervical cancer
cervical carcinoma
Cloning
Demethylation
Epigenetics
Ethanol
Female
Females
Fluorides
Forkhead protein
FTO
Gene expression
Gene Expression Regulation, Neoplastic
Human papillomavirus
Humans
Kinases
Lymphatic system
m6A
Malignancy
Metastases
Metastasis
Mice
Mice, Nude
N6-methyladenosine
PIK3R3
Proteins
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcriptomes
Transfection
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
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Title FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcam4.70507
https://www.ncbi.nlm.nih.gov/pubmed/39692250
https://www.proquest.com/docview/3149189149
https://www.proquest.com/docview/3146950313
https://pubmed.ncbi.nlm.nih.gov/PMC11653219
https://doaj.org/article/051619dfe7b447bfaf248e345fe062a6
Volume 13
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