Successful immunomodulation in kidney transplant recipients with cytokine release syndrome after coronavirus disease
Introduction Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two...
Saved in:
| Published in | IJU case reports Vol. 5; no. 5; pp. 373 - 377 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
John Wiley & Sons, Inc
01.09.2022
John Wiley and Sons Inc Wiley |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Introduction
Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two cases of successful immunomodulation in Japanese kidney transplant recipients with cytokine release syndrome following coronavirus disease.
Case presentation
Two patients who had been receiving long‐term immunosuppressant therapy developed coronavirus disease‐associated pneumonia caused by cytokine release syndrome, following immunosuppressant dosage reduction. However, they recovered immediately after administration of tocilizumab with or without dexamethasone.
Conclusion
The immunosuppressant dosage should be reduced to restore host immunity; however, immunomodulation should be considered in cases of suspected cytokine release syndrome. |
|---|---|
| AbstractList | Introduction
Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two cases of successful immunomodulation in Japanese kidney transplant recipients with cytokine release syndrome following coronavirus disease.
Case presentation
Two patients who had been receiving long‐term immunosuppressant therapy developed coronavirus disease‐associated pneumonia caused by cytokine release syndrome, following immunosuppressant dosage reduction. However, they recovered immediately after administration of tocilizumab with or without dexamethasone.
Conclusion
The immunosuppressant dosage should be reduced to restore host immunity; however, immunomodulation should be considered in cases of suspected cytokine release syndrome. Introduction Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two cases of successful immunomodulation in Japanese kidney transplant recipients with cytokine release syndrome following coronavirus disease. Case presentation Two patients who had been receiving long‐term immunosuppressant therapy developed coronavirus disease‐associated pneumonia caused by cytokine release syndrome, following immunosuppressant dosage reduction. However, they recovered immediately after administration of tocilizumab with or without dexamethasone. Conclusion The immunosuppressant dosage should be reduced to restore host immunity; however, immunomodulation should be considered in cases of suspected cytokine release syndrome. Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two cases of successful immunomodulation in Japanese kidney transplant recipients with cytokine release syndrome following coronavirus disease.IntroductionPatients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two cases of successful immunomodulation in Japanese kidney transplant recipients with cytokine release syndrome following coronavirus disease.Two patients who had been receiving long-term immunosuppressant therapy developed coronavirus disease-associated pneumonia caused by cytokine release syndrome, following immunosuppressant dosage reduction. However, they recovered immediately after administration of tocilizumab with or without dexamethasone.Case presentationTwo patients who had been receiving long-term immunosuppressant therapy developed coronavirus disease-associated pneumonia caused by cytokine release syndrome, following immunosuppressant dosage reduction. However, they recovered immediately after administration of tocilizumab with or without dexamethasone.The immunosuppressant dosage should be reduced to restore host immunity; however, immunomodulation should be considered in cases of suspected cytokine release syndrome.ConclusionThe immunosuppressant dosage should be reduced to restore host immunity; however, immunomodulation should be considered in cases of suspected cytokine release syndrome. IntroductionPatients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with other viral infections. However, currently, treatment methods for such patients have not been established. Here, we describe two cases of successful immunomodulation in Japanese kidney transplant recipients with cytokine release syndrome following coronavirus disease.Case presentationTwo patients who had been receiving long‐term immunosuppressant therapy developed coronavirus disease‐associated pneumonia caused by cytokine release syndrome, following immunosuppressant dosage reduction. However, they recovered immediately after administration of tocilizumab with or without dexamethasone.ConclusionThe immunosuppressant dosage should be reduced to restore host immunity; however, immunomodulation should be considered in cases of suspected cytokine release syndrome. |
| Author | Kodama, Fumihiro Harada, Shigeru Takamoto, Daiji Kataoka, Hiroshi Sasaki, Hajime Higuchi, Haruka Hirano, Tetsuo Tanaka, Hiroshi Takada, Yusuke Harada, Hiroshi |
| AuthorAffiliation | 4 Department of Urology Sapporo City General Hospital Sapporo Japan 2 Department of Rheumatology and Clinical Immunology Sapporo City General Hospital Sapporo Japan 3 Department of Infectious Diseases Sapporo City General Hospital Sapporo Japan 1 Department of Kidney Transplant Surgery Sapporo City General Hospital Sapporo Japan |
| AuthorAffiliation_xml | – name: 1 Department of Kidney Transplant Surgery Sapporo City General Hospital Sapporo Japan – name: 4 Department of Urology Sapporo City General Hospital Sapporo Japan – name: 3 Department of Infectious Diseases Sapporo City General Hospital Sapporo Japan – name: 2 Department of Rheumatology and Clinical Immunology Sapporo City General Hospital Sapporo Japan |
| Author_xml | – sequence: 1 givenname: Daiji surname: Takamoto fullname: Takamoto, Daiji organization: Sapporo City General Hospital – sequence: 2 givenname: Hajime orcidid: 0000-0001-7639-0912 surname: Sasaki fullname: Sasaki, Hajime email: hajimes1207@hotmail.com organization: Sapporo City General Hospital – sequence: 3 givenname: Hiroshi surname: Kataoka fullname: Kataoka, Hiroshi organization: Sapporo City General Hospital – sequence: 4 givenname: Fumihiro surname: Kodama fullname: Kodama, Fumihiro organization: Sapporo City General Hospital – sequence: 5 givenname: Haruka surname: Higuchi fullname: Higuchi, Haruka organization: Sapporo City General Hospital – sequence: 6 givenname: Tetsuo surname: Hirano fullname: Hirano, Tetsuo organization: Sapporo City General Hospital – sequence: 7 givenname: Yusuke surname: Takada fullname: Takada, Yusuke organization: Sapporo City General Hospital – sequence: 8 givenname: Shigeru surname: Harada fullname: Harada, Shigeru organization: Sapporo City General Hospital – sequence: 9 givenname: Hiroshi orcidid: 0000-0001-5121-6686 surname: Harada fullname: Harada, Hiroshi organization: Sapporo City General Hospital – sequence: 10 givenname: Hiroshi surname: Tanaka fullname: Tanaka, Hiroshi organization: Sapporo City General Hospital |
| BookMark | eNp9kk1rFTEUhoNU7Ifd-AsCbkS4NZ93ZjaClGqvFFxowV3IJCdtbmeSa5Jpuf_eTKeIdeEqIefJk_DyHqODEAMg9IaSM0oI--C3kzyjTHTsBTpismlWtKE_D_7aH6LTnLekwoTytWCv0CGXnWCkYUeofJ-MgZzdNGA_jlOIY7TToIuPAfuA77wNsMcl6ZB3gw4FJzB-5yGUjB98ucVmX-KdD1AHA-gMOO-DTXEErF2BhE1MMeh7n6aMrc8z8hq9dHrIcPq0nqDrzxc_zi9XV9--bM4_Xa2MFJStrOkJJbpvSGeEacAw0a5Nx8EJKwXXWkphW6GF47ql0lgnHRXWckmp0y3jJ2izeG3UW7VLftRpr6L26vEgphulU_FmAGU60dV3HJGiF4TpvqbTy643jQXohKiuj4trN_UjWFMDSHp4Jn0-Cf5W3cR71XFJmFxXwbsnQYq_JshFjT4bGGqoEKesWEMIp5x2sqJv_0G3cUqhRjVTbVt1YqbeL5RJMecE7s9nKFFzN9TcDfXYjQrTBX7wA-z_Q6rN12u53PkN6Pm_Ng |
| Cites_doi | 10.1056/NEJMra2026131 10.1016/S2665-9913(20)30277-0 10.1016/j.cell.2020.04.026 10.1136/bmjebm-2020-111536 10.1016/j.transproceed.2021.08.066 10.1001/jama.2020.16337 10.1016/S0140-6736(21)00676-0 10.1111/ajt.16449 10.1111/ajt.16314 10.1073/pnas.2005615117 10.2169/internalmedicine.6010-20 |
| ContentType | Journal Article |
| Copyright | 2022 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. 2022. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. |
| Copyright_xml | – notice: 2022 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. – notice: 2022. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2022 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. |
| DBID | 24P AAYXX CITATION 3V. 7RV 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU COVID DWQXO FYUFA GHDGH K9. KB0 M0S NAPCQ PHGZM PHGZT PIMPY PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1002/iju5.12492 |
| DatabaseName | Wiley Online Library Open Access CrossRef ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Proquest Central ProQuest One Coronavirus Research Database ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Immunomodulation in kidney transplant |
| EISSN | 2577-171X |
| EndPage | 377 |
| ExternalDocumentID | oai_doaj_org_article_c949709f054b402ab072b59bc7dee944 PMC9350256 10_1002_iju5_12492 IJU512492 |
| Genre | caseStudy |
| GroupedDBID | 0R~ 1OC 24P 7RV 7X7 8FI 8FJ AAHHS ABUWG ACCFJ ACCMX ACXQS ADBBV ADKYN ADPDF ADZMN ADZOD AEEZP AEQDE AFKRA AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS AVUZU BCNDV BENPR CCPQU EBS EJD FYUFA GROUPED_DOAJ HMCUK IAO IHR INH ITC NAPCQ OK1 OVD OVEED PIMPY PQQKQ RPM TEORI UKHRP WIN AAYXX CITATION M~E PHGZM PHGZT 3V. 7XB 8FK AAMMB AEFGJ AGXDD AIDQK AIDYY AZQEC COVID DWQXO K9. PKEHL PPXIY PQEST PQUKI PRINS 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c5412-dcb010ab709c4c7ec2486c93ef4d543aa554d84a4f3a815cdf5f14dd3511fa823 |
| IEDL.DBID | 7X7 |
| ISSN | 2577-171X |
| IngestDate | Wed Aug 27 01:32:02 EDT 2025 Thu Aug 21 14:31:05 EDT 2025 Fri Jul 11 07:24:41 EDT 2025 Fri Jul 25 06:59:08 EDT 2025 Tue Jul 01 04:20:43 EDT 2025 Wed Jan 22 16:22:29 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| License | Attribution-NonCommercial This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5412-dcb010ab709c4c7ec2486c93ef4d543aa554d84a4f3a815cdf5f14dd3511fa823 |
| Notes | These authors contributed equally to the manuscript. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Report-3 ObjectType-Case Study-4 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
| ORCID | 0000-0001-5121-6686 0000-0001-7639-0912 |
| OpenAccessLink | https://www.proquest.com/docview/2708825645?pq-origsite=%requestingapplication% |
| PMID | 35942072 |
| PQID | 2708825645 |
| PQPubID | 4570189 |
| PageCount | 377 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c949709f054b402ab072b59bc7dee944 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9350256 proquest_miscellaneous_2700313195 proquest_journals_2708825645 crossref_primary_10_1002_iju5_12492 wiley_primary_10_1002_iju5_12492_IJU512492 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | September 2022 |
| PublicationDateYYYYMMDD | 2022-09-01 |
| PublicationDate_xml | – month: 09 year: 2022 text: September 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | Tokyo |
| PublicationPlace_xml | – name: Tokyo – name: Hoboken |
| PublicationTitle | IJU case reports |
| PublicationYear | 2022 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2020; 324 2020; 117 2021; 26 2021; 21 2022; 54 2020; 2 2021; 397 2020; 383 2020; 20 2021; 60 2020; 181 e_1_2_13_5_1 e_1_2_13_4_1 e_1_2_13_10_1 e_1_2_13_3_1 e_1_2_13_11_1 e_1_2_13_2_1 e_1_2_13_12_1 e_1_2_13_9_1 e_1_2_13_8_1 e_1_2_13_7_1 e_1_2_13_6_1 |
| References_xml | – volume: 324 start-page: 1041 year: 2020 end-page: 2 article-title: Efficacy of remdesivir in COVID‐19 publication-title: JAMA – volume: 383 start-page: 2255 year: 2020 end-page: 73 article-title: Cytokine storm publication-title: N. Engl. J. Med. – volume: 60 start-page: 639 year: 2021 end-page: 43 article-title: Immediate amelioration of severe respiratory distress in Sjogren's syndrome with COVID‐19 treated with a single dose of off‐label tocilizumab publication-title: Intern. Med. – volume: 397 start-page: 1637 year: 2021 end-page: 45 article-title: Tocilizumab in patients admitted to hospital with COVID‐19 (RECOVERY): a randomised, controlled, open‐label, platform trial publication-title: Lancet – volume: 21 start-page: 925 year: 2021 end-page: 37 article-title: Impact of COVID‐19 in solid organ transplant recipients publication-title: Am. J. Transplant. – volume: 181 start-page: 1036 year: 2020 end-page: 45.e9 article-title: Imbalanced host response to SARS‐CoV‐2 drives development of COVID‐19 publication-title: Cell – volume: 20 start-page: 3198 year: 2020 end-page: 205 article-title: Tocilizumab for severe COVID‐19 in solid organ transplant recipients: a matched cohort study publication-title: Am. J. Transplant. – volume: 117 start-page: 10970 year: 2020 end-page: 5 article-title: Effective treatment of severe COVID‐19 patients with tocilizumab publication-title: Proc. Natl. Acad. Sci. USA – volume: 54 start-page: 286 year: 2022 end-page: 92 article-title: No influence of everolimus on mycophenolic acid area under the concentration‐time curve: limited sampling strategy for mycophenolic acid in Japanese kidney transplant recipients treated with tacrolimus, mycophenolate mofetil, steroid, and everolimus publication-title: Transplant. Proc. – volume: 2 start-page: e603 year: 2020 end-page: 12 article-title: Tocilizumab among patients with COVID‐19 in the intensive care unit: a multicentre observational study publication-title: Lancet Rheumatol. – volume: 26 start-page: 107 year: 2021 end-page: 8 article-title: Biomarkers and outcomes of COVID‐19 hospitalisations: systematic review and meta‐analysis publication-title: BMJ Evid. Based Med. – ident: e_1_2_13_2_1 doi: 10.1056/NEJMra2026131 – ident: e_1_2_13_8_1 doi: 10.1016/S2665-9913(20)30277-0 – ident: e_1_2_13_5_1 doi: 10.1016/j.cell.2020.04.026 – ident: e_1_2_13_12_1 doi: 10.1136/bmjebm-2020-111536 – ident: e_1_2_13_3_1 doi: 10.1016/j.transproceed.2021.08.066 – ident: e_1_2_13_6_1 doi: 10.1001/jama.2020.16337 – ident: e_1_2_13_10_1 doi: 10.1016/S0140-6736(21)00676-0 – ident: e_1_2_13_4_1 doi: 10.1111/ajt.16449 – ident: e_1_2_13_9_1 doi: 10.1111/ajt.16314 – ident: e_1_2_13_7_1 doi: 10.1073/pnas.2005615117 – ident: e_1_2_13_11_1 doi: 10.2169/internalmedicine.6010-20 |
| SSID | ssj0002013642 |
| Score | 2.194292 |
| Snippet | Introduction
Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than... IntroductionPatients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than... Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than those with... Introduction Patients with coronavirus disease, especially solid organ transplant recipients, are more susceptible to developing cytokine release syndrome than... |
| SourceID | doaj pubmedcentral proquest crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 373 |
| SubjectTerms | Case Report Case Reports Cell cycle Coronaviruses COVID-19 cytokine release syndrome Cytokine storm Cytokines dexamethasone Drug dosages Fever kidney transplant recipient Kidney transplants Monoclonal antibodies Mortality Patients Pneumonia Severe acute respiratory syndrome coronavirus 2 Steroids tocilizumab Viral infections Writing |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ1NT9wwEIatihOXCtSipkDlCk5IKYljb-IjVEWA1F7oStwsf4rwkSA2qcS_74yTXW04wIVblPhgz9ia17HnGUIOvctMBZExDZkrUi6NSM1M6tQyjfT2iutI2__9Z3Y-55fX4nqt1BfeCRvwwIPhjq3kssxkAGlhYK-jTVYyI6SxpfNe8kgChZi3tpm6jcdreQHKesUjZcf1bS9-YKVlNolAEdQ_UZcv70aua9YYdM62yMdRLdKToZfb5INvPpHuqo9VDkN_T2tM72gfWjdW4aJ1Q-9q1_hn2kVs-T1YjiLB4hETHxcU_7tS-9y1dyAvKVZMgTBGl9wCGkuGU4tYA_2vfuoXdDzB-UzmZ7_-_jxPx-IJqRU8Z6mzBrZa2oDtLLelt4xXMysLH7gTvNAadIQDV_BQ6CoX1gURcu4cHiwGXbFih2w0beO_EMrAeTYLwmJSXHBeOs2MR6xLKGfSh4QcLA2qHgdGhhpoyEyh2VU0e0JO0darFsi1ji_A22r0tnrL2wnZW3pKjYttoViJ-wTE4iTk--ozLBM8-9CNb_vYBimVuYQ25cTDkw5NvzT1TQRuy0KgNEzIUZwLrwxSXVzORXz6-h7D3SWbDNMt4p22PbLRPfV-H0RQZ77F-f4f1eUJdg priority: 102 providerName: Directory of Open Access Journals – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlZ1La9wwEIDFklx6CQlpifNCpT0VnNiytLYglyQ0pAsthWZhb0LPxNnEDrt2IP--Gq3XqXsI5GYsGeQZjTR6zDcIfbUmUYWfGWOXmCymXLFYjbmMNZFAby-oDLT9n7_G11M6mbHZCJ2tY2FWfIh-ww0sI4zXYOBSLU9foaHlfctOIHWyH4A3IbYWLvQR-rvfYSGAIwvZc3y3BBJiOuv5pOT09fPBjBTA_QNv8_-7kv_6sGESutpGW533iM9X6t5BI1vtouZPG7IeuvYBlxDuUT_WpsvKhcsKz0tT2RfcBIz5g5ckBqLFEwRCLjHsw2L90tRzLxAMGVT8tIbXHAMcUohjDZgD-Vwu2iXuTnQ-ounV95vL67hLphBrRlMSG6380kuqPOGa6txqQoux5pl11DCaSen9CuNVQ10mi5Rp45hLqTFw0OhkQbJPaKOqK7uHMPHK1IljGoLknLHcSKIsYF5cPubWRejLWqDiacXMECs6MhEgdhHEHqELkHVfAzjX4UW9uBWd2QjNKfctdt6xVH6lK1WSE8W40rmxllMaocO1pkRnfEtBclg3ACYnQp_7Ym82cBYiK1u3oQ5QK1Pu6-QDDQ8aNCypyrsA4OYZA1cxQt9CX3jjJ8WPyZSFp_33VD5AHwiEWYS7bIdoo1m09sg7P406Dn38L3OaA_4 priority: 102 providerName: Wiley-Blackwell |
| Title | Successful immunomodulation in kidney transplant recipients with cytokine release syndrome after coronavirus disease |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fiju5.12492 https://www.proquest.com/docview/2708825645 https://www.proquest.com/docview/2700313195 https://pubmed.ncbi.nlm.nih.gov/PMC9350256 https://doaj.org/article/c949709f054b402ab072b59bc7dee944 |
| Volume | 5 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfZ1Nb9QwEIZHtL1wQSBABMrKCE5IoVnH3sQnRFGrUomqAlbam-VPSFuSZTdB6r_H4_UuhENvUeKDMzOO34ztZwDeOFvoOsyMuS9smTOhea5nQuWGKqS310xF2v7ni9nZnJ0v-CIl3NZpW-X2mxg_1LYzmCM_ohWKQWSfvF_-yrFqFK6uphIae3CA6DKM6mpR7XIsFIFkjO6opPSouRr4O6y3TEfzUMT1jzTm_zsk_1Wuceo5fQgPkmYkHzZOfgT3XPsY-q9DrHXohxvS4CGP7mdnUy0u0rTkurGtuyV9hJffBPsR5Fgs8fjjmmD2lZjbvrsOIpNg3ZQwmZEtvYDEwuHEINxA_W5Ww5qkdZwnMD89-fbxLE8lFHLD2ZTm1ujww6V0VQjDTOUMZfXMiNJ5ZjkrlQpqwgaHMF-qesqN9dxPmbW4vOhVTcunsN92rXsGhAYXmsJzg0fjvHXCKqodwl18NRPOZ_B6a1C53JAy5IaJTCWaXUazZ3CMtt61QLp1vNGtvss0WKQRTIQe-yAndfi_VbqoqOZCm8o6JxjL4HDrKZmG3Fr-DZAMXu0eh8GCKyCqdd0Q2yCrMoRKBtXIw6MOjZ-0zY-I3RYlR4GYwdsYC3e8pPx0Pufx6vndPX0B9ykep4h71g5hv18N7mUQOb2ewB5ll5MYzxM4OD65uPwyiQmDPxrfBKg |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELZWywEuCASIwAJGwAUpbOrYdXxAiNeq3deFrdSb8RPCLklpE1D_FL8Rj5sUwmFve4sSHybjsWfG4_k-hJ47m-kieMbUZzZPqdAs1WOhUkMUoLcXVEW0_ZPT8WRGD-dsvoN-970wcK2y3xPjRm1rA2fk-4RDMAjYJ28WP1JgjYLqak-hsTGLI7f-FVK21evphzC_Lwg5-Hj2fpJ2rAKpYXREUmt0yEGU5pkw1HBnCC3GRuTOU8torlRwsDbISH2uihEz1jM_otZCxc2rAoAOwpZ_LTjeDJI9PufbMx0CAGiUbFFQyX75rWWvgN-ZDPxepAcYxLT_38j8N1KOru7gFrrZxaj47caobqMdV91Bzac2civ69gKX0FRSf69tx_2Fywqfl7Zya9xEsPSLMF8YcDMW0G65wnDai826qc9DUIuBpyU4T9yjJeBIVI4NgCmon-WyXeGubnQXza5EuffQblVX7j7CJJiMyTwz0IrnrRNWEe0ATMbzsXA-Qc96hcrFBplDbjCYiQS1y6j2BL0DXW9HAJp2fFEvv8hucUojqAgS-xC-6pBPK51xopnQhlvnBKUJ2utnSnZLfCX_GmSCnm4_h8UJFRdVubqNYwAbcyTCGD6Y4YFAwy9V-TXCfIucQUCaoJfRFi75STk9nLH49OBySZ-g65Ozk2N5PD09eohuEGjliPfl9tBus2zdoxBgNfpxtGqMPl_1MvoD0ow-WQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwELamTkK8IBAgwgYYAS9IoaljN_EDQoytWjeoJqDS3ox_QhgkpU1A_df46_C5SSE87G1vUeKHy_nOd2f7vg-hp9YkKveRMXaJSWPKFYvVmMtYEwno7TmVAW3_3Wx8PKcn5-x8B_3uemHgWmW3JoaF2lQa9siHJINkELBPhq69FnF2OHm1-BEDgxSctHZ0GhsTObXrX758W72cHvq5fkbI5Ojjm-O4ZRiINaMjEhutfD0iVZZwTXVmNaH5WPPUOmoYTaX0wdZ4ealLZT5i2jjmRtQYOH1zMgfQA7_872ZQFQ3Q7sHR7Oz9doeHABwaJVtMVDIsvjbsBbA9k14UDGQBvQz3__uZ_-bNIfBNbqIbbcaKX29M7BbaseVtVH9oAtOiVxIuoMWk-l6ZlgkMFyW-KExp17gO0Onf_OxhQNFYQPPlCsPeL9brurrwKS4G1hYfSnGHnYADbTnWAK0gfxbLZoXbU6Q7aH4l6r2LBmVV2nsIE29AOnFMQ2OeM5YbSZQFaBmXjbl1EXrSKVQsNjgdYoPITASoXQS1R-gAdL0dAdja4UW1_CxaVxWaU-4ldj6ZVb66lirJiGJc6cxYyymN0H43U6J1-JX4a54Rerz97F0Vzl9kaasmjAGkzBH3Y7LeDPcE6n8piy8B9JunDNLTCD0PtnDJT4rpyZyFp_uXS_oIXfMuJN5OZ6d76DqBvo5weW4fDeplYx_4bKtWD1uzxujTVXvSH6XxQ_Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Successful+immunomodulation+in+kidney+transplant+recipients+with+cytokine+release+syndrome+after+coronavirus+disease&rft.jtitle=IJU+case+reports&rft.au=Takamoto%2C+Daiji&rft.au=Sasaki%2C+Hajime&rft.au=Kataoka%2C+Hiroshi&rft.au=Kodama%2C+Fumihiro&rft.date=2022-09-01&rft.issn=2577-171X&rft.eissn=2577-171X&rft.volume=5&rft.issue=5&rft.spage=373&rft_id=info:doi/10.1002%2Fiju5.12492&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2577-171X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2577-171X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2577-171X&client=summon |