High‐Intensity Interval Training Mitigates Sarcopenia and Suppresses the Myoblast Senescence Regulator EEF1E1

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 15; no. 6; pp. 2574 - 2585
• Main Authors: Dun, Yaoshan, Zhang, Wenliang, Du, Yang, Xie, Kangling, Liu, Yuan, Li, Cui, Qiu, Ling, Fu, Siqian, Olson, Thomas P., Long, Yuqiong, You, Baiyang, Liu, Suixin
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.12.2024; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Animals; Autophagy; Biomarkers; Cellular Senescence; EEF1E1; Female; Fitness equipment; High-Intensity Interval Training - methods; high‐intensity interval training; Humans; Interval training; Intervention; Laboratory animals; Male; Mice; Musculoskeletal system; Myoblasts - metabolism; Normal distribution; Older people; Original; Peptide Elongation Factor 1 - metabolism; Plasma; Proteins; Proteomics - methods; Running; Sarcopenia; Sarcopenia - metabolism; Sarcopenia - prevention & control; Sarcopenia - therapy; Senescence; Workloads; senescence; high‐intensity interval training; autophagy; EEF1E1; sarcopenia

ABSTRACT Background The optimal exercise regimen for alleviating sarcopenia remains uncertain. This study aimed to investigate the efficacy of high‐intensity interval training (HIIT) over moderate‐intensity continuous training (MICT) in ameliorating sarcopenia. Methods We conducted a randomized cros...