Pharmacokinetic Study of Levetiracetam in Children

• Published in: Epilepsia (Copenhagen) Vol. 42; no. 12; pp. 1574 - 1579
• Main Authors: Pellock, John M., Glauser, Tracy A., Bebin, E. Martina, Fountain, Nathan B., Ritter, Frank J., Coupez, René M., Shields, W. Donald
• Format: Journal Article
• Language: English
• Published: Boston, MA, USA Blackwell Science Inc 01.12.2001; Blackwell
• Subjects: Adult; Age Factors; Anticonvulsants - pharmacokinetics; Anticonvulsants - therapeutic use; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Child; Creatine - metabolism; Epilepsy; Epilepsy - drug therapy; Epilepsy - metabolism; Female; Humans; Keppra; Levetiracetam; Male; Medical sciences; Metabolic Clearance Rate; Middle Aged; Neuropharmacology; Pediatric; Pharmacokinetics; Pharmacology. Drug treatments; Piracetam - analogs & derivatives; Piracetam - pharmacokinetics; Piracetam - therapeutic use; ucb L057; Human; Nervous system diseases; Metabolite; Epilepsy; Multicenter study; Anticonvulsant; Clearance; Metabolism; Cerebral disorder; Chemotherapy; Treatment; Partial; Central nervous system disease; Pharmacokinetics; Child; Levetiracetam

Purpose: The pharmacokinetics of the novel antiepileptic drug (AED) levetiracetam and its major metabolite, ucb L057, were studied in children with partial seizures in a multicenter, open‐label, single‐dose study. Methods: Twenty‐four children (15 boys, nine girls), 6 to 12 years old, received a sin...