Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway

• Published in: Cell death & disease Vol. 12; no. 11; p. 1068
• Main Authors: Zhang, Lin, Wei, Wei, Ai, Xiaoyu, Kilic, Ertugrul, Hermann, Dirk M., Venkataramani, Vivek, Bähr, Mathias, Doeppner, Thorsten R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.11.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13; 13/109; 13/2; 13/31; 13/51; 14/34; 631/378/371; 631/378/87; 64/60; 82; 82/80; Angiogenesis; Animal models; Animals; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Hypoxia - immunology; Cell injury; Endothelial cells; Endothelial Cells - metabolism; Extracellular vesicles; Extracellular Vesicles - metabolism; Humans; Hypoxia; Immunology; Inflammation; Ischemia; Life Sciences; Mice; Microglia; Microglia - metabolism; Neovascularization, Pathologic - metabolism; Recovery of function; Regeneration; Signal transduction; Smad2 protein; Stroke; Stroke - genetics; Stroke - pathology; Transfection; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Transforming growth factor-b1; Transplantation

Systemic transplantation of oxygen−glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. Herein, we analyzed whether or not extracellular vesicles (EVs) derived from su...