Target-responsive vasoactive probes for ultrasensitive molecular imaging

• Published in: Nature communications Vol. 11; no. 1; pp. 2399 - 10
• Main Authors: Ohlendorf, Robert, Wiśniowska, Agata, Desai, Mitul, Barandov, Ali, Slusarczyk, Adrian L., Li, Nan, Jasanoff, Alan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.05.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 59/36; 59/57; 631/1647/245/2160; 631/61/338; 64/86; Animals; Appendages; Biomarkers; Biotin; Biotin - metabolism; Brain - diagnostic imaging; Brain - metabolism; Brain mapping; CHO Cells; Cricetinae; Cricetulus; Dopamine; Dopamine - metabolism; Functional magnetic resonance imaging; Heavy metal content; Heavy metals; HEK293 Cells; Hemodynamics; Humanities and Social Sciences; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mapping; Medical imaging; Molecular Imaging - methods; Molecular Probes - chemistry; Molecular Probes - metabolism; multidisciplinary; Neuroimaging; Neurotransmitter Agents - metabolism; Neurotransmitters; Peptides; Peptides - metabolism; Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry; Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism; Probes; Rats; Reproducibility of Results; Science; Science (multidisciplinary); Selectivity; Target detection; Vasoactive agents; Vasodilator Agents - chemistry; Vasodilator Agents - metabolism; Vasodilators

The ability to monitor molecules volumetrically throughout the body could provide valuable biomarkers for studies of healthy function and disease, but noninvasive detection of molecular targets in living subjects often suffers from poor sensitivity or selectivity. Here we describe a family of potent...