Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden - Qing, Tao; Mohsen, Hussein; Marczyk, Michal; Ye, Yixuan; O’Meara, Tess; Zhao, Hongyu; Townsend, Jeffrey P.; Gerstein, Mark; Hatzis, Christos; Kluger, Yuval; Pusztai, Lajos (Nature communications, 2020)
Keywords: 45/23; 631/67/2195; 631/67/69; Adult; Age; Age Factors; Aged; Aged, 80 and over; Cancer; Coding; Genes; Genetic transformation; Germ-Line Mutation - genetics; Humanities and Social Sciences; Humans; Middle Aged; multidisciplinary; Mutation; Neoplasms - diagnosis; Neoplasms - genetics; Open Reading Frames - genetics; Proteins; Science; Science (multidisciplinary); Signal Transduction - genetics; Structure-function relationships