Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis

• Published in: Scientific reports Vol. 11; no. 1; p. 5682
• Main Authors: Nalesso, Giovanna, Thorup, Anne-Sophie, Eldridge, Suzanne Elizabeth, De Palma, Anna, Kaur, Amanpreet, Peddireddi, Kiran, Blighe, Kevin, Rana, Sharmila, Stott, Bryony, Vincent, Tonia Louise, Thomas, Bethan Lynne, Bertrand, Jessica, Sherwood, Joanna, Fioravanti, Antonella, Pitzalis, Costantino, Dell’Accio, Francesco
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/80/304; 631/80/86; Aged; Animals; Arthritis; Bone Remodeling; Ca2+/calmodulin-dependent protein kinase II; Calcium; Calcium-binding protein; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Calmodulin; Cartilage; Cartilage diseases; Cartilage, Articular - enzymology; Cartilage, Articular - pathology; Cattle; Chondrocytes; Chondrocytes - metabolism; Chondrocytes - pathology; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Interleukin 1; Interleukin-1beta - metabolism; Kinases; Knee; Male; Meniscus; Mice; Mice, Inbred C57BL; Middle Aged; Models, Biological; multidisciplinary; Osteoarthritis; Osteoarthritis - enzymology; Osteoarthritis - genetics; Osteoarthritis - pathology; Oxygenase; Protein Isoforms - antagonists & inhibitors; Protein Isoforms - genetics; Protein Isoforms - metabolism; Science; Science (multidisciplinary); Signal transduction; Therapeutic applications; Transcriptome - genetics; Up-Regulation; Wnt protein; Wnt3 Protein - metabolism

WNT ligands can activate several signalling cascades of pivotal importance during development and regenerative processes. Their de-regulation has been associated with the onset of different diseases. Here we investigated the role of the WNT/Calcium Calmodulin Kinase II (CaMKII) pathway in osteoarthr...