Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans

• Published in: Scientific reports Vol. 10; no. 1; pp. 9971 - 15
• Main Authors: Rosenberg, Aviv A., Weiser-Bitoun, Ido, Billman, George E., Yaniv, Yael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.06.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443; 692/4019; 692/699; Action Potentials - physiology; Adult; Aging; Aging - physiology; Animals; Atrial Fibrillation - physiopathology; Autonomic nervous system; Autonomic Nervous System - physiology; Congestive heart failure; Coronary artery disease; Dogs; Electrocardiography; Electrocardiography - methods; Female; Fibrillation; Heart - physiology; Heart rate; Heart Rate - physiology; Humanities and Social Sciences; Humans; Male; Mathematical models; Middle Aged; multidisciplinary; Nervous system; Pacemakers; Science; Science (multidisciplinary); Sinoatrial Node - physiology; Young Adult

Heart rate and heart rate variability (HRV) are mainly determined by the autonomic nervous system (ANS), which interacts with receptors on the sinoatrial node (SAN; the heart’s primary pacemaker), and by the “coupled-clock” system within the SAN cells. HRV changes are associated with cardiac disease...