Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy

• Published in: Nature communications Vol. 13; no. 1; pp. 2414 - 8
• Main Authors: Prasad, Smriti, Kalafat, Erkan, Blakeway, Helena, Townsend, Rosemary, O’Brien, Pat, Morris, Edward, Draycott, Tim, Thangaratinam, Shakila, Le Doare, Kirsty, Ladhani, Shamez, von Dadelszen, Peter, Magee, Laura A., Heath, Paul, Khalil, Asma
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/590; 631/326/596/4130; 692/699/255/2514; 692/700/478/174; At risk populations; Birth weight; Births; Coronaviruses; COVID-19; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - adverse effects; Embolism; Female; Hemorrhage; Humanities and Social Sciences; Humans; Immunization; Infant, Newborn; Intensive care; Intensive Care Units, Neonatal; Meta-analysis; mRNA; multidisciplinary; Neonates; Placenta; Pregnancy; Premature Birth - epidemiology; RNA, Messenger; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Stillbirth; Stillbirth - epidemiology; Systematic review; Vaccination; Vaccines

Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effe...